INT115948

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Context Info
Confidence 0.26
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 11
Disease Relevance 10.37
Pain Relevance 1.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (MMRN1) cell adhesion (MMRN1)
Anatomy Link Frequency
ECM 4
MMRN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 25 100.00 Very High Very High Very High
cytokine 62 99.86 Very High Very High Very High
Osteoarthritis 8 96.92 Very High Very High Very High
Inflammation 43 94.08 High High
Chronic pancreatitis 66 76.08 Quite High
cINOD 3 70.40 Quite High
corticosteroid 1 68.76 Quite High
fibrosis 31 50.00 Quite Low
agonist 16 33.12 Quite Low
chemokine 13 32.12 Quite Low
Disease Link Frequency Relevance Heat
Uterine Fibroids 600 100.00 Very High Very High Very High
Primary Sclerosing Cholangitis 154 99.80 Very High Very High Very High
Fibrosis 47 97.96 Very High Very High Very High
Osteoarthritis 8 96.92 Very High Very High Very High
Metastasis 42 94.92 High High
Necrosis 4 94.56 High High
Cancer 152 94.20 High High
INFLAMMATION 51 94.08 High High
Cirrhosis 14 91.20 High High
Viral Meningitis 42 91.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The primary role of these cytokines is to modulate the expression of matrix metalloproteinases and cartilage ECM proteins.
Regulation (modulate) of Gene_expression (expression) of ECM in ECM associated with metalloproteinase and cytokine
1) Confidence 0.26 Published 2004 Journal BioDrugs Section Abstract Doc Link 14733605 Disease Relevance 1.14 Pain Relevance 0.76
TGFbeta was subsequently confirmed as a key regulator of ECM production and PSC proliferation due to its inhibition of MMPs in an autocrine fashion which enhanced fibrogenesis by reducing collagen degradation [23].
Regulation (regulator) of Gene_expression (production) of ECM associated with fibrosis and primary sclerosing cholangitis
2) Confidence 0.13 Published 2007 Journal J Transl Med Section Body Doc Link PMC2234395 Disease Relevance 1.60 Pain Relevance 0.25
ATRA regulated expression of individual ECM components
Regulation (individual) of Gene_expression (components) of ECM
3) Confidence 0.08 Published 2008 Journal Clinical Endocrinology Section Body Doc Link PMC2610401 Disease Relevance 0.81 Pain Relevance 0
8m) inhibited growth of leiomyoma cells in culture and regulated expression of leiomyoma cell ECM structural components, proteoglycans, and cytokines to levels that approximated expression patterns of myometrial cells.
Regulation (regulated) of Gene_expression (expression) of ECM associated with uterine fibroids and cytokine
4) Confidence 0.08 Published 2008 Journal Clinical Endocrinology Section Body Doc Link PMC2610401 Disease Relevance 1.30 Pain Relevance 0.09
pathway is also known to play a role in ECM remodelling in various tissues.31 We therefore hypothesized that leiomyoma cells exposed to ATRA would demonstrate lower expression of TGF-?
Regulation (role) of Gene_expression (remodelling) of ECM associated with uterine fibroids
5) Confidence 0.08 Published 2008 Journal Clinical Endocrinology Section Body Doc Link PMC2610401 Disease Relevance 0.99 Pain Relevance 0
ATRA regulated expression of individual ECM components
Regulation (regulated) of Gene_expression (expression) of ECM
6) Confidence 0.08 Published 2008 Journal Clinical Endocrinology Section Body Doc Link PMC2610401 Disease Relevance 0.87 Pain Relevance 0
Thus, the effect of coculture on ECM protein production seems to be rather independent of the transcription of the respective mRNA moieties, but may involve changes in protein processing/sorting or protein secretion.


Regulation (effect) of Gene_expression (production) of ECM protein
7) Confidence 0.08 Published 2007 Journal J Transl Med Section Body Doc Link PMC2234395 Disease Relevance 0.66 Pain Relevance 0.15
by such agents has been reported, underlining the importance of ECM remodeling
Regulation (importance) of Gene_expression (remodeling) of ECM
8) Confidence 0.05 Published 2008 Journal PPAR Research Section Body Doc Link PMC2366048 Disease Relevance 0.53 Pain Relevance 0
Our results demonstrated that a rise in ATRA exposure impacted leiomyoma cell proliferation and altered ECM production.
Regulation (altered) of Gene_expression (production) of ECM associated with uterine fibroids
9) Confidence 0.05 Published 2008 Journal Clinical Endocrinology Section Body Doc Link PMC2610401 Disease Relevance 1.08 Pain Relevance 0.08
These will be discussed within the context of changes in expression and functional heterodimerization patterns of integrins, changes in ECM expression and reorganization by proteases facilitating invasion.
Regulation (changes) of Gene_expression (expression) of ECM in ECM
10) Confidence 0.05 Published 2004 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC320496 Disease Relevance 1.09 Pain Relevance 0
The activated urokinase converts pro-enzyme, plasminogen into plasmin, a serine protease involved in the ECM destruction by degrading fibrin.
Regulation (involved) of Gene_expression (destruction) of ECM
11) Confidence 0.04 Published 2006 Journal BMC Microbiol Section Body Doc Link PMC1464133 Disease Relevance 0.31 Pain Relevance 0

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