INT115963

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Context Info
Confidence 0.59
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 4.53
Pain Relevance 1.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CRH) extracellular space (CRH) extracellular region (CRH)
response to stress (CRH)
Anatomy Link Frequency
uterine 4
hypothalamus 2
cervix 2
pituitary gland 2
CRH (Homo sapiens)
Pain Link Frequency Relevance Heat
antidepressant 12 98.68 Very High Very High Very High
rheumatoid arthritis 79 97.04 Very High Very High Very High
substance P 2 96.76 Very High Very High Very High
cytokine 50 95.08 Very High Very High Very High
depression 6 91.64 High High
Inflammation 46 89.16 High High
corticosteroid 18 84.48 Quite High
antagonist 2 78.80 Quite High
opiate 6 78.36 Quite High
narcan 2 77.92 Quite High
Disease Link Frequency Relevance Heat
Pulmonary Disease 66 100.00 Very High Very High Very High
Heart Failure 62 100.00 Very High Very High Very High
Chronic Renal Failure 55 100.00 Very High Very High Very High
Sepsis 66 99.96 Very High Very High Very High
Neurodegenerative Disease 2 99.12 Very High Very High Very High
Adrenal Insufficiency 11 98.36 Very High Very High Very High
Critical Illness 7 98.04 Very High Very High Very High
Rheumatoid Arthritis 79 97.04 Very High Very High Very High
Sleep Disorders 6 93.80 High High
Attention Deficit Hyperactivity Disorder 2 93.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Clinically effective therapy with antidepressant drugs normalizes the disturbed activity of HPA axis, in part, by decreasing corticotropin-releasing hormone (CRH) synthesis, but the mechanism of this action is poorly recognized.
Negative_regulation (decreasing) of Gene_expression (synthesis) of corticotropin-releasing hormone associated with antidepressant
1) Confidence 0.59 Published 2004 Journal Neuropsychopharmacology Section Abstract Doc Link 14735130 Disease Relevance 0.19 Pain Relevance 0.22
Clinically effective therapy with antidepressant drugs normalizes the disturbed activity of HPA axis, in part, by decreasing corticotropin-releasing hormone (CRH) synthesis, but the mechanism of this action is poorly recognized.
Negative_regulation (decreasing) of Gene_expression (synthesis) of CRH associated with antidepressant
2) Confidence 0.43 Published 2004 Journal Neuropsychopharmacology Section Abstract Doc Link 14735130 Disease Relevance 0.19 Pain Relevance 0.22
Expression of CRH-BP, CRH-R1 and CRH-R2 in uterine tissues is down-regulated during pregnancy.
Negative_regulation (regulated) of Gene_expression (Expression) of CRH in uterine
3) Confidence 0.41 Published 2006 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC1513580 Disease Relevance 0.07 Pain Relevance 0
Expression of CRH-BP, CRH-R1 and CRH-R2 in uterine tissues is down-regulated during pregnancy.
Negative_regulation (down) of Gene_expression (Expression) of CRH in uterine
4) Confidence 0.41 Published 2006 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC1513580 Disease Relevance 0.07 Pain Relevance 0
The detection of substantial expression of the CRH and its receptor proteins, as well as receptor mRNA in the cervix suggests that the cervix may be a target for CRH action.
Negative_regulation (detection) of Gene_expression (expression) of CRH in cervix
5) Confidence 0.41 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1513580 Disease Relevance 0.07 Pain Relevance 0
During sepsis, suppression of CRH synthesis may also result from neuronal apoptosis, which may be triggered by elevation in substance P [19] or inducible nitric oxide synthase (NOS) in the hypothalamus [20].
Negative_regulation (suppression) of Gene_expression (synthesis) of CRH in hypothalamus associated with neurodegenerative disease, sepsis and substance p
6) Confidence 0.27 Published 2004 Journal Crit Care Section Body Doc Link PMC522845 Disease Relevance 1.00 Pain Relevance 0.42
Sepsis may result in decreased CRH or ACTH synthesis by inducing irreversible anatomical damage to the hypothalamus or the pituitary gland.
Negative_regulation (decreased) of Gene_expression (synthesis) of CRH in pituitary gland associated with sepsis
7) Confidence 0.27 Published 2004 Journal Crit Care Section Body Doc Link PMC522845 Disease Relevance 0.37 Pain Relevance 0
5.1 How do self-perceived symptoms, care needs, caregiver burden, preferences with regard to life-sustaining treatments, end-of-life care communication and management of patients with severe to very severe COPD, CHF and CRF change over time according to the patients and their closest relatives?
Negative_regulation (severe) of Gene_expression (change) of CRF associated with chronic renal failure, pulmonary disease and heart failure
8) Confidence 0.22 Published 2008 Journal BMC Palliat Care Section Body Doc Link PMC2391145 Disease Relevance 1.67 Pain Relevance 0
Glucocorticoids exert negative feedback control on the HPA axis by suppressing hypothalamic CRH production and ACTH secretion.
Negative_regulation (suppressing) of Gene_expression (production) of CRH
9) Confidence 0.07 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206381 Disease Relevance 0.91 Pain Relevance 0.63

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