INT115982

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Context Info
Confidence 0.50
First Reported 2004
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 18
Total Number 19
Disease Relevance 19.81
Pain Relevance 1.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (KRT7) nucleolus (KRT7) structural molecule activity (KRT7)
nucleus (KRT7) cytoskeleton organization (KRT7) cytoplasm (KRT7)
Anatomy Link Frequency
stromal cells 2
colon 2
thyroid 1
gastric epithelium 1
neuron 1
KRT7 (Homo sapiens)
Pain Link Frequency Relevance Heat
endometriosis 117 95.96 Very High Very High Very High
imagery 28 88.64 High High
Crohn's disease 2 83.76 Quite High
colic 1 82.40 Quite High
abdominal pain 14 79.32 Quite High
Pain 12 78.00 Quite High
transdermal 2 55.08 Quite High
Inflammation 10 44.72 Quite Low
backache 2 42.88 Quite Low
Bile 1 34.92 Quite Low
Disease Link Frequency Relevance Heat
Cancer 308 99.90 Very High Very High Very High
Transitional Cell Carcinoma 8 99.90 Very High Very High Very High
Breast Cancer 48 99.78 Very High Very High Very High
Colon Cancer 47 99.66 Very High Very High Very High
Malignant Neoplastic Disease 80 99.62 Very High Very High Very High
Carcinoma 121 99.46 Very High Very High Very High
Lung Cancer 25 99.14 Very High Very High Very High
Stomach Cancer 9 98.48 Very High Very High Very High
Endometrial Cancer 18 98.14 Very High Very High Very High
Increased Venous Pressure Under Development 2 97.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The ileocecal lesion was diagnosed as a recurrence because of the histological findings, which included mucosal preservation, a similarity with the histologic type of stomach carcinoma, and atypical immunoreactivity for primary colon carcinoma; the lesion was negative for both cytokeratin 7 and cytokeratin 20.
Positive_regulation (negative) of cytokeratin 7 in colon associated with colon cancer, stomach cancer and recurrence
1) Confidence 0.50 Published 2004 Journal Acta Med. Okayama Section Abstract Doc Link 15551760 Disease Relevance 0.94 Pain Relevance 0.16
Immunohistochemical staining revealed a "biliary pattern" of cytokeratin subset immunoreactivity, with positivity for cytokeratin 7 and an absence of staining with cytokeratin 20.
Positive_regulation (positivity) of cytokeratin 7
2) Confidence 0.49 Published 2004 Journal Arch. Pathol. Lab. Med. Section Abstract Doc Link 14736268 Disease Relevance 0.74 Pain Relevance 0.11
The benign gastric epithelium were negative for both CK7 and CK20 (figure 2C), while the malignant colonic epithelium was positive for CK20 (figure 2C) and negative for CK7 supporting the dual population of cells in the gastric mucosal biopsies.


Positive_regulation (negative) of CK7 in gastric epithelium associated with malignant neoplastic disease
3) Confidence 0.37 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2734526 Disease Relevance 0.90 Pain Relevance 0
All endometrial carcinomas with transitional cell differentiation are negative for cytokeratin 20 (CK20), but half are positive for cytokeratin 7 (CK7) [3].
Positive_regulation (positive) of CK7 associated with endometrial cancer
4) Confidence 0.36 Published 2007 Journal Diagn Pathol Section Body Doc Link PMC1947947 Disease Relevance 0.95 Pain Relevance 0
All endometrial carcinomas with transitional cell differentiation are negative for cytokeratin 20 (CK20), but half are positive for cytokeratin 7 (CK7) [3].
Positive_regulation (positive) of cytokeratin 7 associated with endometrial cancer
5) Confidence 0.36 Published 2007 Journal Diagn Pathol Section Body Doc Link PMC1947947 Disease Relevance 0.95 Pain Relevance 0
In our case, the thyroid sample was negative for TTF-1, CK 7, and CK 20, but positive for alpha-fetoprotein, which is relatively specific for HCC, although of low sensitivity [14].
Positive_regulation (negative) of CK 7 in thyroid associated with hepatocellular cancer
6) Confidence 0.21 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC2246133 Disease Relevance 1.01 Pain Relevance 0.07
However, among PF cells obtained during the late follicular phase prior to uterine flushing and cultured in vitro, other investigators could not identify EM cells that were immunocytologically positive for cytokeratins 5/7/8/14/19, cytokeratin 7/18, epithelial marker: BW495/36, HMFG 2, EM epithelial marker NEND-3 or ovarian carcinoma related markers OV-TL3, OV-TL10, OC-125 [27].
Positive_regulation (positive) of cytokeratin 7 in uterine associated with increased venous pressure under development and reprotox - general 1
7) Confidence 0.20 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2789082 Disease Relevance 0.36 Pain Relevance 0.08
We used immunohistochemical staining to distinguish primary non-small cell lung cancer from colon cancer; the resected tumor was positive for TTF-1 and CK7, but negative for CK20.
Positive_regulation (positive) of CK7 in colon associated with lung cancer, cancer and colon cancer
8) Confidence 0.19 Published 2009 Journal Nihon Kokyuki Gakkai Zasshi Section Abstract Doc Link 19601528 Disease Relevance 1.48 Pain Relevance 0.08
The mesenteric mass found at the first operation stained positive for CK7 and negative for CK20, where as the splenic flexure mass was positive for both CK7 and CK20.
Positive_regulation (positive) of CK7
9) Confidence 0.13 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC1802866 Disease Relevance 1.36 Pain Relevance 0.05
Clinical and histopathological data were reviewed and immunohistochemical analysis was performed for S100, CD56, neuron-specific enolase, epithelial membrane antigen, CK7, CK8, CK14, and CK20.
Positive_regulation (performed) of CK7 in neuron
10) Confidence 0.12 Published 2009 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Abstract Doc Link 19913727 Disease Relevance 0.08 Pain Relevance 0.08
Both, the epithelial and the stromal cells tested positive for estrogen receptors and for CK7, while tests for CK20 proved negative.
Positive_regulation (tested) of CK7 in stromal cells
11) Confidence 0.11 Published 2006 Journal World J Surg Oncol Section Body Doc Link PMC1712233 Disease Relevance 0.86 Pain Relevance 0.08
Once again, immunohistochemical features of these foci included positive estrogen receptors and a positive result on CK7 in the epithelial and stromal cells, and negative results for CK20.
Positive_regulation (result) of CK7 in stromal cells
12) Confidence 0.11 Published 2006 Journal World J Surg Oncol Section Body Doc Link PMC1712233 Disease Relevance 0.87 Pain Relevance 0.17
Neoplastic cells showed positive immunohistochemical staining for pankeratin, estrogen receptor, and CK7 and were negative for progesterone receptor, carcinoembryonic antigen (CEA), and CK20 in sections from both sites (not shown).
Positive_regulation (staining) of CK7
13) Confidence 0.08 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2831908 Disease Relevance 0.69 Pain Relevance 0
Her immunohistochemistry was positive for CA125, WT1, CK7, and ER.
Positive_regulation (positive) of CK7
14) Confidence 0.07 Published 2007 Journal J Med Case Reports Section Body Doc Link PMC2204026 Disease Relevance 1.16 Pain Relevance 0.04
Endometroid carcinomas are immunohistochemically positive for CK7, progesterone and estrogen receptors while transitional cell carcinomas are positive for CK7 and CK20.
Positive_regulation (positive) of CK7 associated with carcinoma and transitional cell carcinoma
15) Confidence 0.05 Published 2011 Journal Diagn Pathol Section Body Doc Link PMC3024921 Disease Relevance 2.06 Pain Relevance 0
Endometroid carcinomas are immunohistochemically positive for CK7, progesterone and estrogen receptors while transitional cell carcinomas are positive for CK7 and CK20.
Positive_regulation (positive) of CK7 associated with carcinoma and transitional cell carcinoma
16) Confidence 0.05 Published 2011 Journal Diagn Pathol Section Body Doc Link PMC3024921 Disease Relevance 1.98 Pain Relevance 0
Metastatic breast carcinomas are often positive for Cytokeratin 7(CK7), GCDFP-15, ER and/or PgR.
Positive_regulation (positive) of CK7 associated with breast cancer
17) Confidence 0.03 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1550421 Disease Relevance 0.65 Pain Relevance 0.07
Immunohistochemical staining of the malignant ascitic cells was positive for CA 125, WT-1, CK7 and ER but negative for CK20, TTF-1, PR, Calretinin and BRST-2.
Positive_regulation (positive) of CK7 associated with malignant neoplastic disease
18) Confidence 0.03 Published 2007 Journal J Med Case Reports Section Body Doc Link PMC2204026 Disease Relevance 1.23 Pain Relevance 0.15
Immunohistochemical staining was positive for cytokeratin 20 and carcinoembryonic antigen (CEA), and negative for cytokeratin 7 and carbohydrate antigen (CA)-125, suggesting the origin of the tumor was more likely to be gastrointestinal than urogenital.
Positive_regulation (negative) of cytokeratin 7 associated with cancer
19) Confidence 0.01 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2873455 Disease Relevance 1.55 Pain Relevance 0

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