INT115987

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Context Info
Confidence 0.44
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.52
Pain Relevance 0.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (SPARC) extracellular space (SPARC) extracellular region (SPARC)
proteinaceous extracellular matrix (SPARC) nucleus (SPARC) intracellular (SPARC)
SPARC (Homo sapiens)
Pain Link Frequency Relevance Heat
Etanercept 7 98.24 Very High Very High Very High
metalloproteinase 63 97.92 Very High Very High Very High
COX2 1 94.28 High High
cytokine 7 89.88 High High
Inflammation 33 85.48 High High
Infliximab 5 78.52 Quite High
Pain 8 75.96 Quite High
corticosteroid 2 27.16 Quite Low
Multiple sclerosis 1 24.36 Low Low
Arthritis 5 22.28 Low Low
Disease Link Frequency Relevance Heat
Heterotopic Ossification 8 99.08 Very High Very High Very High
INFLAMMATION 35 85.48 High High
Dermatomyositis 16 80.16 Quite High
Pancreatitis 4 79.56 Quite High
Ankylosis 1 78.44 Quite High
Pain 5 75.96 Quite High
Osteoporosis 1 75.00 Quite High
Calcification 40 74.24 Quite High
Brain Injury 1 71.88 Quite High
Injury 1 63.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This quantitative study demonstrated a specific and strong overexpression of osteocalcin mRNA in HO-isolated cells associated with a significant upregulation of type 1 collagen and osteonectin mRNA while histological analysis showed only small cellular variations.
Positive_regulation (upregulation) of osteonectin mRNA associated with heterotopic ossification
1) Confidence 0.44 Published 2004 Journal Exp. Mol. Pathol. Section Abstract Doc Link 14738867 Disease Relevance 0.88 Pain Relevance 0.08
The calcified deposits contained the bone proteins osteopontin, osteonectin, and sialoprotein.
Positive_regulation (proteins) of osteonectin
2) Confidence 0.25 Published 2010 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2831027 Disease Relevance 0.56 Pain Relevance 0.48
Collagen types I and III, fibronectin, matrix metalloproteinases (MMPs), tissue inhibitors of MMPs (TIMPs) and reversion-inducing cysteine-rich protein with Kazal motifs (RECK) were demonstrated on protein and mRNA level.
Positive_regulation (inducing) of cysteine-rich protein
3) Confidence 0.05 Published 2009 Journal Pancreatology Section Body Doc Link 19077460 Disease Relevance 0.08 Pain Relevance 0
2-macroglobin, heparin and the reversion-inducing cysteine-rich protein with kazal motifs (RECK) [4, 5].
Positive_regulation (inducing) of cysteine-rich protein
4) Confidence 0.03 Published 2009 Journal Marine Drugs Section Body Doc Link PMC2707034 Disease Relevance 0 Pain Relevance 0.44

General Comments

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