INT11599

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Context Info
Confidence 0.19
First Reported 1989
Last Reported 1993
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 0.30
Pain Relevance 4.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Calca, Npr1) extracellular space (Calca) aging (Calca)
extracellular region (Calca) plasma membrane (Npr1) nucleus (Calca)
Anatomy Link Frequency
spleen 2
smooth muscle 1
Calca (Rattus norvegicus)
Npr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 57 100.00 Very High Very High Very High
medulla 12 97.56 Very High Very High Very High
adenocard 3 96.96 Very High Very High Very High
qutenza 42 93.52 High High
headache 1 87.76 High High
ganglionectomy 2 83.92 Quite High
antagonist 1 75.48 Quite High
Neuropeptide 3 25.00 Low Low
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 3 94.96 High High
Hypotension 2 66.24 Quite High
Hypersensitivity 2 44.24 Quite Low
Headache 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cortical and medullary adenylate cyclase was stimulated in a concentration-dependent manner by salmon calcitonin, rat calcitonin and rat CGRP.
calcitonin Positive_regulation (stimulated) of cyclase associated with calcitonin gene-related peptide
1) Confidence 0.19 Published 1989 Journal Neuroscience Section Abstract Doc Link 2787487 Disease Relevance 0 Pain Relevance 1.11
Cortical and medullary adenylate cyclase was stimulated in a concentration-dependent manner by salmon calcitonin, rat calcitonin and rat CGRP.
CGRP Positive_regulation (stimulated) of cyclase associated with calcitonin gene-related peptide
2) Confidence 0.19 Published 1989 Journal Neuroscience Section Abstract Doc Link 2787487 Disease Relevance 0 Pain Relevance 1.12
Cortical and medullary adenylate cyclase was stimulated in a concentration-dependent manner by salmon calcitonin, rat calcitonin and rat CGRP.
calcitonin Positive_regulation (stimulated) of cyclase associated with calcitonin gene-related peptide
3) Confidence 0.14 Published 1989 Journal Neuroscience Section Abstract Doc Link 2787487 Disease Relevance 0 Pain Relevance 1.12
Rat alpha-CGRP (rCGRP) activated adenylate cyclase in homogenates of rat spleen (basal activity 45 +/- 8.27, delta Vmax 75 +/- 16 pmol cyclic AMP min-1 protein; K(act) 2.04 +/- 0.44 nM).
rCGRP Positive_regulation (activated) of cyclase in spleen associated with calcitonin gene-related peptide
4) Confidence 0.06 Published 1993 Journal Regul. Pept. Section Abstract Doc Link 8387220 Disease Relevance 0.07 Pain Relevance 0.38
Rat alpha-CGRP (rCGRP) activated adenylate cyclase in homogenates of rat spleen (basal activity 45 +/- 8.27, delta Vmax 75 +/- 16 pmol cyclic AMP min-1 protein; K(act) 2.04 +/- 0.44 nM).
alpha-CGRP Positive_regulation (activated) of cyclase in spleen associated with calcitonin gene-related peptide
5) Confidence 0.06 Published 1993 Journal Regul. Pept. Section Abstract Doc Link 8387220 Disease Relevance 0.07 Pain Relevance 0.38
We conclude that the nitrovasodilators activate sensory fibers to release CGRP, which in turn relaxes cerebral vascular smooth muscle by activating guanylate cyclase.
CGRP Positive_regulation (activating) of guanylate cyclase in smooth muscle associated with calcitonin gene-related peptide
6) Confidence 0.02 Published 1992 Journal Circ. Res. Section Abstract Doc Link 1576743 Disease Relevance 0.17 Pain Relevance 0.67

General Comments

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