INT1160

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.57
First Reported 1975
Last Reported 2010
Negated 4
Speculated 7
Reported most in Abstract
Documents 122
Total Number 130
Disease Relevance 28.19
Pain Relevance 90.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA processing (Rbm39) RNA binding (Rbm39) nucleus (Rbm39)
Anatomy Link Frequency
spinal cord 7
spinal 6
tail 4
neurons 4
NK cell 3
Rbm39 (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 884 100.00 Very High Very High Very High
Glutamate 757 100.00 Very High Very High Very High
Glutamate receptor 231 100.00 Very High Very High Very High
agonist 135 100.00 Very High Very High Very High
opioid receptor 131 100.00 Very High Very High Very High
mu opioid receptor 82 100.00 Very High Very High Very High
Opioid 67 100.00 Very High Very High Very High
Hyperalgesia 64 100.00 Very High Very High Very High
gABA 64 100.00 Very High Very High Very High
Kappa opioid receptor 38 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hyperalgesia 102 100.00 Very High Very High Very High
Hypersensitivity 116 99.80 Very High Very High Very High
Nociception 379 99.72 Very High Very High Very High
Ovarian Cancer 4 99.60 Very High Very High Very High
Neuropathic Pain 352 99.56 Very High Very High Very High
Anxiety Disorder 56 99.52 Very High Very High Very High
Amnesia 4 99.40 Very High Very High Very High
Drug Induced Neurotoxicity 10 99.26 Very High Very High Very High
Diabetes Mellitus 21 99.14 Very High Very High Very High
INFLAMMATION 230 98.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Studies with azidomorphine derivatives have revealed that some of them, particularly N-cyclopropylmethylnorazidomorphine (CAM), stimulate some opiate receptors, while inhibit the others.
Positive_regulation (stimulate) of receptors associated with opiate
1) Confidence 0.57 Published 1977 Journal Pol J Pharmacol Pharm Section Abstract Doc Link 196268 Disease Relevance 0.06 Pain Relevance 0.72
In contrast, exposure of BALB/c mice to acute stress and chronic treatment of nonstressed BALB/c mice with fluoxetine elicit significant, site-specific increases in 5-HT2C pre-mRNA editing that increase the pool of mRNA encoding receptors with reduced function.
Positive_regulation (increase) of receptors associated with stress and fluoxetine
2) Confidence 0.43 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15659601 Disease Relevance 0.91 Pain Relevance 0.83
Most of them are GABAergic and their activity is synaptically driven by the activation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid/kainate receptors.
Positive_regulation (activation) of receptors associated with gabaergic
3) Confidence 0.40 Published 2005 Journal Neuroscience Section Abstract Doc Link 16112471 Disease Relevance 0 Pain Relevance 0.07
However, upon intracerebroventricular (i.c.v.) administration in Swiss Webster mice, heroin and 6MAM act on delta receptors while morphine acts on mu receptors.
Positive_regulation (acts) of receptors associated with intracerebroventricular and morphine
4) Confidence 0.38 Published 2000 Journal J. Biomed. Sci. Section Abstract Doc Link 10810246 Disease Relevance 0 Pain Relevance 1.17
Pretreatment with naloxone, an opioid receptor antagonist (1.0 and 4.0 mg/kg, s.c.), failed to reverse the morphine-evoked behavioral response, suggesting that the morphine effect is not mediated through the opioid receptors in the spinal cord.
Neg (not) Positive_regulation (mediated) of receptors in spinal cord associated with antagonist, narcan, opioid receptor, spinal cord and morphine
5) Confidence 0.36 Published 2002 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11834301 Disease Relevance 0.08 Pain Relevance 1.04
We show that post-training surgical anesthesia leads to robust context specific retrograde amnesia in mice, and post-anesthesia activation of EphA receptors induces a significant amelioration of this amnesia.
Positive_regulation (activation) of receptors associated with anesthesia, acupuncture and amnesia
6) Confidence 0.35 Published 2000 Journal Behav. Brain Res. Section Abstract Doc Link 10701657 Disease Relevance 0.45 Pain Relevance 0.27
Naloxone-induced withdrawal signs were elicited equally in mice chronically treated with 7-hydroxymitragynine or morphine. 7-Hydroxymitragynine exhibited a potent antinociceptive effect based on activation of mu-opioid receptors and its morphine-like pharmacological character, but 7-hydroxymitragynine is structurally different from morphine.
Positive_regulation (activation) of receptors associated with mu opioid receptor, narcan, antinociceptive, withdrawal and morphine
7) Confidence 0.34 Published 2005 Journal Life Sci. Section Abstract Doc Link 16169018 Disease Relevance 0.07 Pain Relevance 1.56
Subcutaneous (s.c.) administration of 7-hydroxymitragynine produced a potent antinociceptive effect mainly through activation of mu-opioid receptors.
Positive_regulation (activation) of receptors associated with mu opioid receptor and antinociceptive
8) Confidence 0.34 Published 2005 Journal Life Sci. Section Abstract Doc Link 16169018 Disease Relevance 0.07 Pain Relevance 1.49
Additionally, at higher concentrations, ketamine directly activates these GABA(A) receptors.
Positive_regulation (activates) of receptors associated with gaba and ketamine
9) Confidence 0.33 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18480294 Disease Relevance 0.22 Pain Relevance 0.74
These studies suggest that activation of alpha(7) receptors in the CNS elicits antinociceptive effects in an acute thermal pain model.
Positive_regulation (activation) of receptors associated with pain and antinociceptive
10) Confidence 0.32 Published 2000 Journal Neuropharmacology Section Abstract Doc Link 11044748 Disease Relevance 0.29 Pain Relevance 1.02
These results suggest that activation of combinations of receptors (by morphine) was required for the multiplicative interaction.
Positive_regulation (activation) of receptors associated with morphine
11) Confidence 0.25 Published 1991 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1646321 Disease Relevance 0 Pain Relevance 1.29
Activation of metabotropic glutamate receptors induces propagating network oscillations in the intact cerebral cortex of the newborn mouse.
Positive_regulation (Activation) of receptors in cerebral cortex associated with glutamate receptor and cerebral cortex
12) Confidence 0.24 Published 2006 Journal Neuropharmacology Section Title Doc Link 16876205 Disease Relevance 0 Pain Relevance 0.56
Activation of metabotropic glutamate receptors (mGluRs) with (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid (ACPD) elicited in the frontal or occipital pole of the intact cerebral cortex preparation of the newborn mouse (P0-P3) a transient oscillatory field potential activity in the frequency range of 11-14Hz.
Positive_regulation (Activation) of receptors in pole associated with glutamate receptor and cerebral cortex
13) Confidence 0.24 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16876205 Disease Relevance 0 Pain Relevance 0.34
Also, antinociception produced by i.c.v. heroin was inhibited by intrathecal administration of bicuculline and picrotoxin consistent with the concept that delta1 receptors in the brain mediated the antinociceptive response through descending neuronal pathways to the spinal cord to activate GABAA and GABAB receptors rather than spinal alpha2-adrenergic and serotonergic receptors activated originally by the mu agonist action in naive mice.
Positive_regulation (activate) of receptors in neuronal associated with antinociception, agonist, antinociceptive, spinal cord and intrathecal
14) Confidence 0.20 Published 2000 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 10806416 Disease Relevance 0 Pain Relevance 1.40
Nor-binaltorphimine antagonized systemic nalbuphine analgesia over 10-fold more potently after intrathecal injection of the antagonist than after i.c.v. administration, implying a role for kappa 1 receptors at the spinal level.
Positive_regulation (role) of receptors in spinal associated with antagonist, nalbuphine, intrathecal and analgesia
15) Confidence 0.18 Published 1992 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1326621 Disease Relevance 0 Pain Relevance 2.03
Therefore, we suggest that the effects of the selective GABA(A) and NMDA receptors on convulsive behavior are special to their sites of action, and that the inhibitory action of thiopental on NMDA receptors is possibly not mediated by secondary effects of its GABA(A) receptors agonism.
Neg (not) Spec (possibly) Positive_regulation (mediated) of receptors associated with gaba and nmda receptor
16) Confidence 0.18 Published 2007 Journal Pharmacology Section Abstract Doc Link 17534122 Disease Relevance 0.34 Pain Relevance 0.66
Activation of mu-opioid receptors are required for the conditioned enhancement of NK cell activity.
Positive_regulation (Activation) of receptors in NK cell associated with mu opioid receptor
17) Confidence 0.17 Published 1996 Journal Brain Res. Section Title Doc Link 8930374 Disease Relevance 0 Pain Relevance 0.49
The results showed that the activation of mu-opioid receptors was required in the conditioned enhancement of NK cell activity, but not the delta- or kappa-type of receptors.
Positive_regulation (activation) of receptors in NK cell associated with mu opioid receptor
18) Confidence 0.17 Published 1996 Journal Brain Res. Section Abstract Doc Link 8930374 Disease Relevance 0 Pain Relevance 0.50
The tail-flick inhibition induced by beta-endorphin administered intrathecally is mediated by activation of kappa- and mu-opioid receptors in the mouse.
Positive_regulation (activation) of receptors in tail associated with mu opioid receptor, tail-flick and enkephalin
19) Confidence 0.15 Published 1992 Journal Eur. J. Pharmacol. Section Title Doc Link 1316280 Disease Relevance 0 Pain Relevance 0.79
The results indicate that the inhibition of the tail-flick response induced by beta-endorphin given i.t. is mediated by the stimulation of kappa- and mu-opioid receptors but not delta- and epsilon-opioid receptors, alpha 2-adrenoceptors or 5-HT receptors.
Positive_regulation (stimulation) of receptors in tail associated with mu opioid receptor, tail-flick and opioid receptor
20) Confidence 0.15 Published 1992 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1316280 Disease Relevance 0 Pain Relevance 0.75

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox