INT116011

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Context Info
Confidence 0.31
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 3.17
Pain Relevance 4.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

anatomical structure formation involved in morphogenesis (Gata3) cell morphogenesis (Gata3) DNA binding (Gata3)
signal transduction (Gata3) nucleolus (Gata3) nucleus (Gata3)
Anatomy Link Frequency
T cells 2
Gata3 (Mus musculus)
Pain Link Frequency Relevance Heat
Opioid 10 99.98 Very High Very High Very High
Inflammation 48 99.76 Very High Very High Very High
withdrawal 11 99.34 Very High Very High Very High
Morphine 22 99.12 Very High Very High Very High
cytokine 17 94.56 High High
Kappa opioid receptor 2 92.20 High High
opioid receptor 2 90.44 High High
antagonist 14 89.88 High High
agonist 10 79.04 Quite High
Inflammatory response 8 74.88 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 20 99.84 Very High Very High Very High
INFLAMMATION 58 99.76 Very High Very High Very High
Bordatella Infection 2 99.56 Very High Very High Very High
Reperfusion Injury 64 91.84 High High
Injury 7 83.04 Quite High
Apoptosis 12 81.84 Quite High
Death 12 76.08 Quite High
Drug Dependence 1 70.68 Quite High
Cv Unclassified Under Development 24 68.84 Quite High
Renal Disease 4 46.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, Western blot and EMSA experiments revealed that morphine withdrawal-induced Th2 differentiation was mediated through the classical Th2 transcription factors Stat-6 and GATA-3.
Positive_regulation (mediated) of GATA-3 associated with withdrawal and morphine
1) Confidence 0.31 Published 2005 Journal J. Immunol. Section Abstract Doc Link 16081842 Disease Relevance 0 Pain Relevance 1.42
In addition, we also demonstrate that chronic morphine treatment resulted in an increase in GATA 3 binding to DNA consensus elements in electromobility shift assays and an increase in GATA 3 protein and mRNA levels.
Positive_regulation (increase) of GATA 3 associated with morphine
2) Confidence 0.31 Published 2004 Journal J. Neuroimmunol. Section Abstract Doc Link 14741432 Disease Relevance 0.07 Pain Relevance 0.69
In the other hand, the anti-inflammatory components GATA-3, IL-4 and IL-10 were increased in knockout mice (Figure 4c, d and e) and R-954 treated group (Figure 5d, e and f).
Positive_regulation (increased) of GATA-3 associated with targeted disruption and inflammation
3) Confidence 0.25 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516176 Disease Relevance 1.52 Pain Relevance 0.44
Furthermore, activation of the Th2 transcriptional factor GATA-3 followed by IL-4, IL-5, IL-6, IL-10 and IL-13 production was shown to be protective, whereas higher expression of the transcriptional factor T-bet, and IL-12, IL-1?
Positive_regulation (activation) of GATA-3
4) Confidence 0.23 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516176 Disease Relevance 1.16 Pain Relevance 0.21
Micro-opioids inhibited synthesis of common transcription factors AP-1, c-fos, NF-kappaB, and nuclear factor of activated T cells in activated or stimulated immune cells, whereas micro-opioids activated NF-kappaB, GATA-3, and Kruppel-like factor 7 transcription factors in non-stimulated immune cells.
Positive_regulation (activated) of GATA-3 in T cells associated with opioid
5) Confidence 0.03 Published 2006 Journal Neuroimmunomodulation Section Abstract Doc Link 16612131 Disease Relevance 0 Pain Relevance 0.90
We investigated the intracellular mechanism by which morphine controls CD4+ T cell differentiation and demonstrate that morphine treatment in vitro 1) increases anti CD3/CD28 Ab-induced CD4+ T cell IL-4 protein synthesis, IL-4 mRNA, and GATA-3 mRNA accumulation through a pertussis toxin-sensitive receptor; 2) results in a dose-dependent increase in anti-CD3/CD28 Ab-induced CD4+ T cell cytoplasmic cAMP concentration; and 3) increases the forskolin-stimulated cytoplasmic cAMP level through a pertussis toxin-sensitive receptor.
Positive_regulation (accumulation) of GATA-3 mRNA in T cell associated with bordatella infection and morphine
6) Confidence 0.01 Published 2005 Journal J. Immunol. Section Abstract Doc Link 16272288 Disease Relevance 0.42 Pain Relevance 0.56

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