INT116014

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Context Info
Confidence 0.63
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.24
Pain Relevance 1.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

anatomical structure formation involved in morphogenesis (Gata3) cell morphogenesis (Gata3) DNA binding (Gata3)
signal transduction (Gata3) nucleolus (Gata3) nucleus (Gata3)
Anatomy Link Frequency
synaptic vesicle 1
Gata3 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 90 99.98 Very High Very High Very High
Morphine 8 98.16 Very High Very High Very High
cytokine 31 94.68 High High
trigeminal ganglion 66 92.64 High High
Inflammatory response 11 88.80 High High
drug abuse 1 70.20 Quite High
Neurotransmitter 3 65.96 Quite High
ischemia 15 50.00 Quite Low
fibrosis 3 43.44 Quite Low
Pain 4 33.36 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 105 99.98 Very High Very High Very High
Targeted Disruption 30 94.52 High High
Ganglion Cysts 70 92.64 High High
Reperfusion Injury 32 86.52 High High
Pressure And Volume Under Development 3 81.60 Quite High
Bacterial Infection 1 74.32 Quite High
Drug Dependence 1 70.20 Quite High
Neurodegenerative Disease 6 62.60 Quite High
Colitis 12 56.24 Quite High
Myocardial Infarction 1 55.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These differentially regulated transcripts include the transcription factors Tcfap2b, Gata3 and NeuroD4, the calcium binding protein calbindin2 (calretinin), and the small GTP-binding protein Rab3b, implicated in synaptic vesicle release [34].
Transcription (transcription) of Gata3 in synaptic vesicle
1) Confidence 0.63 Published 2007 Journal Neural Develop Section Body Doc Link PMC1796875 Disease Relevance 0.62 Pain Relevance 0.23
ligands (troglitazone, pioglitazone, and rosiglitazone) increases the expression of the specific Th2 transcription factor, GATA-3.
Transcription (transcription) of GATA-3
2) Confidence 0.41 Published 2010 Journal PPAR Research Section Body Doc Link PMC2796461 Disease Relevance 0.23 Pain Relevance 0.21
We found that B1R gene deletion or antagonism resulted in higher expression of the anti-inflammatory GATA-3, IL-4 and IL-10 and lower transcription of the pro-inflammatory T-bet and IL-1?.
Transcription (transcription) of GATA-3 associated with inflammation
3) Confidence 0.36 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516176 Disease Relevance 1.32 Pain Relevance 0.33
In addition, we also demonstrate that chronic morphine treatment resulted in an increase in GATA 3 binding to DNA consensus elements in electromobility shift assays and an increase in GATA 3 protein and mRNA levels.
Transcription (levels) of GATA 3 associated with morphine
4) Confidence 0.23 Published 2004 Journal J. Neuroimmunol. Section Abstract Doc Link 14741432 Disease Relevance 0.07 Pain Relevance 0.69

General Comments

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