INT116015

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Context Info
Confidence 0.22
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.41
Pain Relevance 1.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

anatomical structure formation involved in morphogenesis (Gata3) cell morphogenesis (Gata3) DNA binding (Gata3)
signal transduction (Gata3) nucleolus (Gata3) nucleus (Gata3)
Gata3 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 42 99.64 Very High Very High Very High
Inflammation 54 99.46 Very High Very High Very High
Morphine 8 99.20 Very High Very High Very High
antagonist 7 92.24 High High
ischemia 13 88.72 High High
drug abuse 1 88.40 High High
chemokine 2 84.12 Quite High
Pain 1 76.92 Quite High
Inflammatory response 5 68.00 Quite High
bradykinin 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 60 99.46 Very High Very High Very High
Reperfusion Injury 32 96.28 Very High Very High Very High
Cv Unclassified Under Development 12 88.72 High High
Drug Dependence 1 88.40 High High
Pain 1 76.92 Quite High
Pressure And Volume Under Development 2 76.56 Quite High
Thymoma 1 74.72 Quite High
Aggression 1 73.52 Quite High
Coronary Artery Disease 1 72.32 Quite High
Myocardial Infarction 1 66.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Animals treated with R-954 showed an increased anti-inflammatory cytokine profile, whereby GATA-3, IL-4 and IL-10 were up regulated while T-bet and IL-1?
Regulation (regulated) of GATA-3 associated with inflammation and cytokine
1) Confidence 0.22 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516176 Disease Relevance 1.25 Pain Relevance 0.59
Chronic morphine treatment differentiates T helper cells to Th2 effector cells by modulating transcription factors GATA 3 and T-bet.
Regulation (modulating) of GATA 3 associated with cytokine and morphine
2) Confidence 0.12 Published 2004 Journal J. Neuroimmunol. Section Title Doc Link 14741432 Disease Relevance 0.09 Pain Relevance 0.75
However, the molecular mechanisms that regulate GATA-3 activity are unclear.
Regulation (regulate) of GATA-3
3) Confidence 0.08 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 0.07 Pain Relevance 0.09

General Comments

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