INT116016

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Context Info
Confidence 0.21
First Reported 2004
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.50
Pain Relevance 1.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

anatomical structure formation involved in morphogenesis (Gata3) cell morphogenesis (Gata3) DNA binding (Gata3)
signal transduction (Gata3) nucleolus (Gata3) nucleus (Gata3)
Anatomy Link Frequency
T cell 2
Gata3 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 14 99.54 Very High Very High Very High
opioid receptor 1 93.88 High High
drug abuse 1 74.36 Quite High
cytokine 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Bordatella Infection 2 99.56 Very High Very High Very High
Injury 3 86.48 High High
Drug Dependence 1 74.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, we also demonstrate that chronic morphine treatment resulted in an increase in GATA 3 binding to DNA consensus elements in electromobility shift assays and an increase in GATA 3 protein and mRNA levels.
Positive_regulation (increase) of Positive_regulation (increase) of GATA 3 associated with morphine
1) Confidence 0.21 Published 2004 Journal J. Neuroimmunol. Section Abstract Doc Link 14741432 Disease Relevance 0.07 Pain Relevance 0.71
We investigated the intracellular mechanism by which morphine controls CD4+ T cell differentiation and demonstrate that morphine treatment in vitro 1) increases anti CD3/CD28 Ab-induced CD4+ T cell IL-4 protein synthesis, IL-4 mRNA, and GATA-3 mRNA accumulation through a pertussis toxin-sensitive receptor; 2) results in a dose-dependent increase in anti-CD3/CD28 Ab-induced CD4+ T cell cytoplasmic cAMP concentration; and 3) increases the forskolin-stimulated cytoplasmic cAMP level through a pertussis toxin-sensitive receptor.
Positive_regulation (increases) of Positive_regulation (accumulation) of GATA-3 mRNA in T cell associated with bordatella infection and morphine
2) Confidence 0.00 Published 2005 Journal J. Immunol. Section Abstract Doc Link 16272288 Disease Relevance 0.43 Pain Relevance 0.57

General Comments

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