INT116032

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Context Info
Confidence 0.70
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 2.19
Pain Relevance 0.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il1rn) extracellular region (Il1rn) nucleus (Il1rn)
lipid metabolic process (Il1rn) cytoplasm (Il1rn)
Anatomy Link Frequency
fat 2
Spleen 1
Il1rn (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 85 100.00 Very High Very High Very High
antagonist 3 100.00 Very High Very High Very High
long-term potentiation 1 92.68 High High
Inflammation 68 91.68 High High
Hippocampus 13 82.88 Quite High
Inflammatory marker 2 76.80 Quite High
withdrawal 5 75.00 Quite High
Inflammatory response 7 72.00 Quite High
Morphine 2 68.96 Quite High
ischemia 1 40.32 Quite Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 4 100.00 Very High Very High Very High
INFLAMMATION 79 91.68 High High
Sepsis 57 90.96 High High
Obesity 82 87.76 High High
Infection 31 87.20 High High
Cognitive Disorder 37 84.60 Quite High
Disease 10 66.48 Quite High
Shock 3 51.88 Quite High
Anxiety Disorder 5 49.28 Quite Low
Injury 3 46.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At that time, HFD-fed mice had increased serum levels and fat mRNA expression of the immune suppressing cytokines interleukin-1 receptor antagonist (IL-1Ra) and IL-10 compared with LFD-fed mice.
Transcription (expression) of IL-1Ra in fat associated with antagonist and cytokine
1) Confidence 0.70 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2765728 Disease Relevance 0.71 Pain Relevance 0.15
Spleen cells from withdrawn mice also showed decreased mRNA levels of IL-1beta, IL-1-Ra, and TNF-alpha and a suppression of co-stimulatory molecule expression.
Transcription (levels) of IL-1-Ra in Spleen associated with rheumatoid arthritis
2) Confidence 0.69 Published 2004 Journal J. Neuroimmunol. Section Abstract Doc Link 14741440 Disease Relevance 0.10 Pain Relevance 0.29
At that time, HFD-fed mice had increased serum levels and fat mRNA expression of the immune suppressing cytokines interleukin-1 receptor antagonist (IL-1Ra) and IL-10 compared with LFD-fed mice.
Transcription (expression) of interleukin-1 receptor antagonist in fat associated with antagonist and cytokine
3) Confidence 0.52 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2765728 Disease Relevance 0.71 Pain Relevance 0.15
Transcription of endogenous IL-1Ra would normally occur temporally delayed from the synthesis of IL-1, thus following pharmacological intervention we aimed to block the receptor a priori impeding binding and limiting the damage mediated by the effector molecule.
Transcription (Transcription) of IL-1Ra
4) Confidence 0.30 Published 2010 Journal Crit Care Section Body Doc Link PMC2911722 Disease Relevance 0.67 Pain Relevance 0.25

General Comments

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