INT116033

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Context Info
Confidence 0.42
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 2.05
Pain Relevance 1.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il1b) aging (Il1b) extracellular region (Il1b)
Anatomy Link Frequency
liver 2
RAW 264 2
Spleen 2
prefrontal 2
Il1b (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 7 100.00 Very High Very High Very High
gABA 8 99.70 Very High Very High Very High
Thermal hyperalgesia 1 94.04 High High
allodynia 2 93.04 High High
cytokine 4 91.52 High High
Pain 2 91.24 High High
qutenza 3 88.80 High High
Sciatic nerve 1 86.68 High High
Neuropeptide 2 85.76 High High
Neurotransmitter 1 85.28 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 7 100.00 Very High Very High Very High
Rheumatoid Arthritis 1 99.72 Very High Very High Very High
Nociception 1 96.40 Very High Very High Very High
Multiple Sclerosis 3 94.72 High High
Hyperalgesia 1 94.04 High High
Neuropathic Pain 7 93.04 High High
Wound Healing 3 92.64 High High
Pain 2 91.24 High High
Injury 3 90.80 High High
Nervous System Injury 1 76.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It also inhibited TNF-alpha and IL-1beta mRNA expression, and increased IL-10 mRNA expression in LPS-treated murine liver.
Negative_regulation (inhibited) of Transcription (expression) of IL-1beta in liver
1) Confidence 0.42 Published 2010 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19878665 Disease Relevance 0.26 Pain Relevance 0.59
Human MSCs reduced the mRNA levels of the pro-inflammatory interleukin IL-1beta mouse gene, as well as the neural beta-galactosidase over-activation in prefrontal cortex of SNI mice.
Negative_regulation (reduced) of Transcription (levels) of IL-1beta in prefrontal associated with inflammation
2) Confidence 0.42 Published 2010 Journal Cell. Mol. Life Sci. Section Abstract Doc Link 19937263 Disease Relevance 1.16 Pain Relevance 0.67
Spleen cells from withdrawn mice also showed decreased mRNA levels of IL-1beta, IL-1-Ra, and TNF-alpha and a suppression of co-stimulatory molecule expression.
Negative_regulation (decreased) of Transcription (levels) of IL-1beta in Spleen associated with rheumatoid arthritis
3) Confidence 0.41 Published 2004 Journal J. Neuroimmunol. Section Abstract Doc Link 14741440 Disease Relevance 0.10 Pain Relevance 0.24
It was observed that GABA significantly inhibited the mRNA expression of iNOS, IL-1beta, and TNF-alpha, in LPS-stimulated RAW 264.7 cells.
Negative_regulation (inhibited) of Transcription (expression) of IL-1beta in RAW 264 associated with gaba
4) Confidence 0.41 Published 2007 Journal J. Microbiol. Biotechnol. Section Abstract Doc Link 18156782 Disease Relevance 0.52 Pain Relevance 0.44

General Comments

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