INT116034

Context Info Confidence 0.41 First Reported 2004 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.17 Pain Relevance 0.29

cell proliferation (Tnf) signal transduction (Tnf) extracellular space (Tnf) extracellular region (Tnf) plasma membrane (Tnf) intracellular (Tnf)

Anatomy Link Frequency Spleen 2 Tnf (Mus musculus)

Pain Link Frequency Relevance Heat withdrawal 5 75.00 Morphine 2 69.56 narcan 2 25.00 COX2 2 10.00 cOX1 2 10.00 Analgesic 3 5.00 Inflammation 3 5.00 Earache 1 5.00 Rheumatism 1 5.00

Disease Link Frequency Relevance Heat Rheumatoid Arthritis 1 100.00 INFLAMMATION 3 69.16 Earache 1 5.00 Rheumatic Diseases 1 5.00 Fever 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Spleen cells from withdrawn mice also showed decreased mRNA levels of IL-1beta, IL-1-Ra, and TNF-alpha and a suppression of co-stimulatory molecule expression.

Negative_regulation (decreased) of Transcription (levels) of TNF-alpha in Spleen associated with rheumatoid arthritis

1) Confidence 0.41 Published 2004 Journal J. Neuroimmunol. Section Abstract Doc Link 14741440 Disease Relevance 0.10 Pain Relevance 0.29

RESULTS: We found that the ethanol extract dose dependently inhibit mRNA expression of COX-2, TNF-alpha, iNOS and COX-2 protein expression.

Negative_regulation (inhibit) of Transcription (expression) of TNF-alpha

2) Confidence 0.37 Published 2009 Journal J Ethnopharmacol Section Body Doc Link 19393729 Disease Relevance 0.07 Pain Relevance 0

General Comments

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