INT116034

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Context Info
Confidence 0.41
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.17
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Tnf) signal transduction (Tnf) extracellular space (Tnf)
extracellular region (Tnf) plasma membrane (Tnf) intracellular (Tnf)
Anatomy Link Frequency
Spleen 2
Tnf (Mus musculus)
Pain Link Frequency Relevance Heat
withdrawal 5 75.00 Quite High
Morphine 2 69.56 Quite High
narcan 2 25.00 Low Low
COX2 2 10.00 Low Low
cOX1 2 10.00 Low Low
Analgesic 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Earache 1 5.00 Very Low Very Low Very Low
Rheumatism 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 1 100.00 Very High Very High Very High
INFLAMMATION 3 69.16 Quite High
Earache 1 5.00 Very Low Very Low Very Low
Rheumatic Diseases 1 5.00 Very Low Very Low Very Low
Fever 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Spleen cells from withdrawn mice also showed decreased mRNA levels of IL-1beta, IL-1-Ra, and TNF-alpha and a suppression of co-stimulatory molecule expression.
Negative_regulation (decreased) of Transcription (levels) of TNF-alpha in Spleen associated with rheumatoid arthritis
1) Confidence 0.41 Published 2004 Journal J. Neuroimmunol. Section Abstract Doc Link 14741440 Disease Relevance 0.10 Pain Relevance 0.29
RESULTS: We found that the ethanol extract dose dependently inhibit mRNA expression of COX-2, TNF-alpha, iNOS and COX-2 protein expression.
Negative_regulation (inhibit) of Transcription (expression) of TNF-alpha
2) Confidence 0.37 Published 2009 Journal J Ethnopharmacol Section Body Doc Link 19393729 Disease Relevance 0.07 Pain Relevance 0

General Comments

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