INT116056

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.33
First Reported 2004
Last Reported 2008
Negated 2
Speculated 0
Reported most in Body
Documents 8
Total Number 11
Disease Relevance 0.27
Pain Relevance 1.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PRKG1) signal transduction (PRKG1) plasma membrane (PRKG1)
cytoplasm (PRKG1)
Anatomy Link Frequency
intermediary 4
tail 4
hypothalamus 2
platelet 2
PRKG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 478 100.00 Very High Very High Very High
antagonist 5 98.84 Very High Very High Very High
Serotonin 11 98.76 Very High Very High Very High
Neurotransmitter 11 97.56 Very High Very High Very High
anesthesia 1 91.52 High High
Hippocampus 8 91.08 High High
depression 11 86.44 High High
medulla 4 83.88 Quite High
GABAergic 15 81.40 Quite High
long-term potentiation 13 71.00 Quite High
Disease Link Frequency Relevance Heat
Hypertension 27 99.36 Very High Very High Very High
Obsessive-compulsive Disorder 1 88.52 High High
Depression 11 86.44 High High
Increased Venous Pressure Under Development 23 42.20 Quite Low
Adhesions 5 34.96 Quite Low
Atherosclerosis 12 13.12 Low Low
Thrombosis 22 10.96 Low Low
Injury 8 8.24 Low Low
Stress 24 5.00 Very Low Very Low Very Low
Targeted Disruption 19 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Specifically, prostacyclin-desensitization occurs by direct PKA phosphorylation of Ser329 while NO-desensitization occurs through PKG phosphorylation of Ser331, both within the unique C-tail domain of TP?
Positive_regulation (occurs) of Phosphorylation (phosphorylation) of PKG in tail
1) Confidence 0.33 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
undergoes agonist-induced PKG phosphorylation, we investigated the effect of KT 5823 on TP?
Positive_regulation (undergoes) of Phosphorylation (phosphorylation) of PKG associated with agonist
2) Confidence 0.31 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.22
, is also desensitized by the platelet antagonist /vasodilator nitric oxide (NO), involving direct NO/cGMP-dependent PKG phosphorylation of TP?
Positive_regulation (dependent) of Phosphorylation (phosphorylation) of PKG in platelet associated with antagonist
3) Confidence 0.24 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0.05
is not subject to direct PKA or PKG phosphorylation, its signaling by prostacyclin or NO may only be regulated at downstream intermediary level(s), such as at the level of RhoA phosphorylation.
Positive_regulation (direct) of Phosphorylation (phosphorylation) of PKG in intermediary
4) Confidence 0.24 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
itself, namely through site specific prostacyclin-induced PKA (at Ser329) and NO-induced PKG (at Ser331) phosphorylation rather than at some other intermediary in the RhoA signaling cascade.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of PKG in intermediary
5) Confidence 0.24 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0.04
entails a closed feedback loop involving eNOS phosphorylation/activation, NO generation and subsequent PKG phosphorylation is a mechanism not typically associated with homologous desensitization of GPCRs in general, it is also in agreement with our previous studies demonstrating that TP?
Neg (NO) Positive_regulation (activation) of Phosphorylation (phosphorylation) of PKG
6) Confidence 0.22 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.05
entails a closed feedback loop involving eNOS phosphorylation/activation, NO generation and subsequent PKG phosphorylation is a mechanism not typically associated with homologous desensitization of GPCRs in general, it is also in agreement with our previous studies demonstrating that TP?
Neg (NO) Positive_regulation (subsequent) of Phosphorylation (phosphorylation) of PKG
7) Confidence 0.22 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.05
, is also a target for nitric oxide (NO)-induced heterologous desensitization of signalling that occurs through direct cGMP-dependent PKG/cGK phosphorylation at Ser331 also within its C-tail [35].
Positive_regulation (dependent) of Phosphorylation (phosphorylation) of PKG in tail
8) Confidence 0.22 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.06
undergoes agonist-induced PKG phosphorylation, we investigated the effect of KT 5823 on TP?
Positive_regulation (induced) of Phosphorylation (phosphorylation) of PKG associated with agonist
9) Confidence 0.21 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.22
Baroreceptor activation induced by 30 min of sustained hypertension significantly and sequentially increased the level of cyclic GMP-dependent protein kinase I (PKG-I), phosphorylated cyclic AMP response element-binding protein (pCREB), c-fos mRNA, and Fos protein in the NTS.
Positive_regulation (increased) of Phosphorylation (phosphorylated) of PKG associated with hypertension
10) Confidence 0.05 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 14742673 Disease Relevance 0.10 Pain Relevance 0.13
For example, it has been found that PKG-dependent phosphorylation of a threonine residue on the serotonin transporter enhanced serotonin uptake (Ramamoorthy et al., 2007), an effect that may contribute to the lowering of extracellular serotonin brought about by the NO–cGMP pathway observed in the hypothalamus (Kaehler et al., 1999), and to obsessive–compulsive disorder in humans (Zhang et al., 2007a).
Positive_regulation (dependent) of Phosphorylation (phosphorylation) of PKG in hypothalamus associated with obsessive-compulsive disorder and serotonin
11) Confidence 0.04 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2610389 Disease Relevance 0.17 Pain Relevance 0.54

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox