INT116077

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Context Info
Confidence 0.67
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 2.32
Pain Relevance 2.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (EPHB2)
Anatomy Link Frequency
plasma 4
EPHB2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory response 10 100.00 Very High Very High Very High
Opioid 2 99.80 Very High Very High Very High
Kinase C 1 99.58 Very High Very High Very High
Morphine 5 98.58 Very High Very High Very High
bradykinin 12 97.60 Very High Very High Very High
Inflammation 129 97.52 Very High Very High Very High
b2 receptor 3 95.76 Very High Very High Very High
Immobilon 3 95.12 Very High Very High Very High
cytokine 14 92.00 High High
Glutamate 2 89.92 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 133 100.00 Very High Very High Very High
Inflammatory Bowel Disease 94 92.12 High High
Mycobacterial Infection 2 83.20 Quite High
Breast Cancer 1 82.44 Quite High
Malignant Neoplastic Disease 1 78.48 Quite High
Pressure And Volume Under Development 1 71.00 Quite High
Pain 1 70.52 Quite High
Increased Venous Pressure Under Development 1 70.28 Quite High
Hypersensitivity 5 67.24 Quite High
Erythrocytosis 11 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The finding was also confirmed by the activation of Erk1/2, which was significantly increased in cells from EPOR truncated subjects, grown for 7 days with EPO (Figure 6A).
Positive_regulation (increased) of Positive_regulation (activation) of Erk1
1) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2916842 Disease Relevance 0.07 Pain Relevance 0.05
In addition, receptor internalization by morphine was facilitated by inhibition of protein kinase C and opioid-mediated transactivation of epidermal growth factor receptor (EGFR), both activating ERK/MAP kinases by opioids.
Positive_regulation (transactivation) of Positive_regulation (activating) of ERK associated with kinase c, opioid and morphine
2) Confidence 0.49 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14742744 Disease Relevance 0 Pain Relevance 1.09
Intracellular effects of B2 stimulation were the following: (a) the increase of free intracellular Ca(2+) concentration by a mechanism dependent upon the phospholipase C (PLC) activity; (b) the cytosol-to-membrane translocation of conventional (PKC)-alpha and -beta isozymes, novel PKC-delta, -epsilon, and -eta isozymes; (c) the phosphorylation of the extracellular-regulated kinase 1 and 2 (ERK1/2); and (d) the stimulation of the expression of c-Fos protein.
Positive_regulation (following) of Positive_regulation (increase) of ERK
3) Confidence 0.49 Published 2004 Journal J. Cell. Physiol. Section Abstract Doc Link 15281091 Disease Relevance 0.44 Pain Relevance 0.54
induced pro-inflammatory responses including: (1) assembly of plasma membrane actin; (2) activation of MAP kinases ERK and p38; and (3) activation of NF-?
Positive_regulation (induced) of Positive_regulation (activation) of ERK in plasma associated with inflammatory response
4) Confidence 0.49 Published 2010 Journal International Journal of Molecular Sciences Section Abstract Doc Link PMC2996791 Disease Relevance 0.91 Pain Relevance 0.23
induced pro-inflammatory responses including: (1) assembly of plasma membrane actin; (2) activation of MAP kinases ERK and p38; and (3) activation of NF-?
Positive_regulation (activation) of Positive_regulation (activation) of ERK in plasma associated with inflammatory response
5) Confidence 0.49 Published 2010 Journal International Journal of Molecular Sciences Section Abstract Doc Link PMC2996791 Disease Relevance 0.89 Pain Relevance 0.23

General Comments

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