INT116082

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Context Info
Confidence 0.62
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 0.58
Pain Relevance 3.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (TP53INP2)
TP53INP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 20 100.00 Very High Very High Very High
Morphine 12 99.84 Very High Very High Very High
antidepressant 6 99.24 Very High Very High Very High
Opioid 6 96.80 Very High Very High Very High
Antinociceptive 2 94.64 High High
depression 4 93.92 High High
Pain 2 91.84 High High
Glutamate 2 91.60 High High
MU agonist 6 91.20 High High
imagery 49 88.28 High High
Disease Link Frequency Relevance Heat
Depression 4 93.92 High High
Pain 2 91.84 High High
Cognitive Disorder 5 63.12 Quite High
Keloid Scars 3 54.48 Quite High
Handedness 29 49.28 Quite Low
Cerebral Palsy 1 5.00 Very Low Very Low Very Low
Complex Regional Pain Syndromes 1 5.00 Very Low Very Low Very Low
Nociception 1 5.00 Very Low Very Low Very Low
Disease 1 5.00 Very Low Very Low Very Low
Stroke 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of the delta-opioid receptor (DOR) system produces an interesting behavioral profile distinct from that of other opioids.
Positive_regulation (Activation) of DOR associated with opioid receptor and opioid
1) Confidence 0.62 Published 2006 Journal Mol. Interv. Section Abstract Doc Link 16809477 Disease Relevance 0.20 Pain Relevance 0.89
Arrestin considerably translocates toward the cell membrane upon DOR activation by morphine in presence of the MAP kinase blocker, but it fails in the absence of PD98059.
Positive_regulation (activation) of DOR associated with morphine
2) Confidence 0.57 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14742744 Disease Relevance 0 Pain Relevance 0.86
CONCLUSIONS: Our results demonstrate that expression of three types of ORs, MOR, DOR and KOR, was markedly upregulated in human hypertrophic scars, suggesting a possible link between upregulated ORs and local cacaesthesia in hypertrophic scars.


Positive_regulation (upregulated) of DOR
3) Confidence 0.38 Published 2008 Journal Br. J. Dermatol. Section Body Doc Link 18284397 Disease Relevance 0.05 Pain Relevance 0
When ERK/MAP kinase phosphorylation was blocked by 2'-Amino-3'-methoxyflavone (PD98059), morphine gained the ability to strongly induce DOR endocytosis.
Positive_regulation (induce) of DOR associated with morphine
4) Confidence 0.38 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14742744 Disease Relevance 0 Pain Relevance 0.94
For example, DOR activation stimulates robust antidepressant-like effects in preclinical assays, suggesting that these compounds may have therapeutic potential for treating human depression.
Positive_regulation (activation) of DOR associated with antidepressant, depression and opioid receptor
5) Confidence 0.36 Published 2006 Journal Mol. Interv. Section Abstract Doc Link 16809477 Disease Relevance 0.27 Pain Relevance 1.06
In contrast, both Set-2 (in-plane-rotated, back- and palm view stimuli) and Set-3 (in-plane- and in-depth-rotated, back- and palm view stimuli) revealed a significant DOR effect.
Positive_regulation (effect) of DOR
6) Confidence 0.16 Published 2010 Journal Exp Brain Res Section Body Doc Link PMC2871105 Disease Relevance 0.06 Pain Relevance 0.13

General Comments

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