INT116114

Context Info Confidence 0.12 First Reported 2004 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 8 Total Number 8 Disease Relevance 3.99 Pain Relevance 1.75

cell differentiation (EID1) nucleus (EID1) cell cycle (EID1) cytoplasm (EID1)

EID1 (Homo sapiens)

Pain Link Frequency Relevance Heat cINOD 8 99.84 corticosteroid 2 98.96 qutenza 11 97.28 Pyramidal cell 52 95.60 aspirin 3 89.12 Enkephalin 1 80.00 Inflammation 20 79.48 Opioid 2 78.40 Inflammatory stimuli 2 71.68 narcan 1 70.56

Disease Link Frequency Relevance Heat Retinoblastoma 10 100.00 Apoptosis 13 99.50 Disease 83 97.44 Congenital Anomalies 3 92.56 Cancer 99 89.84 Obesity 140 86.60 Tauopathy 80 81.88 INFLAMMATION 24 79.48 Pancreatic Cancer 15 79.28 Head & Neck Cancer 2 75.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Using SCC-1 cells, OGF decreased the phosphorylation of retinoblastoma protein.

Phosphorylation (phosphorylation) of retinoblastoma protein associated with retinoblastoma

1) Confidence 0.12 Published 2007 Journal Cancer Res. Section Abstract Doc Link 17974995 Disease Relevance 0.25 Pain Relevance 0.27

The inhibition of cyclin D1-CDK4/6 complex activity prevents retinoblastoma protein phosphorylation and release of E2F, leading to the inhibition of cell cycle in G1/S transition [3].

Phosphorylation (phosphorylation) of retinoblastoma protein associated with retinoblastoma

2) Confidence 0.07 Published 2005 Journal BMC Gastroenterol Section Body Doc Link PMC1185532 Disease Relevance 1.01 Pain Relevance 0

This effect correlated with the down-regulation of the expression of cyclin D1 that led to inhibition of cyclin-dependent kinase 4-mediated phosphorylation of retinoblastoma protein.

Phosphorylation (phosphorylation) of retinoblastoma protein associated with retinoblastoma

3) Confidence 0.05 Published 2004 Journal Cancer Res. Section Abstract Doc Link 14744780 Disease Relevance 0.31 Pain Relevance 0.85

Moreover, because of its biological effects, that is, inhibition of p53-induced apoptosis [28] and suppression of phosphorylation of the retinoblastoma protein [29], its drop might contribute to the favorable course of the disease.

Phosphorylation (phosphorylation) of retinoblastoma protein associated with disease, retinoblastoma and apoptosis

4) Confidence 0.02 Published 2010 Journal Clinical and Developmental Immunology Section Body Doc Link PMC3004381 Disease Relevance 0.67 Pain Relevance 0

to hypophosphorylated retinoblastoma protein (RB) and histone deacetylase 3 (HDAC3) [18].

Phosphorylation (hypophosphorylated) of retinoblastoma protein associated with retinoblastoma

5) Confidence 0.01 Published 2009 Journal PPAR Research Section Body Doc Link PMC2830574 Disease Relevance 0.33 Pain Relevance 0.08

Cyclins D1, D2, D3 with cdk4 and cdk6, regulate G1/S transition by releasing E2F transcription factors via increased phosphorylation of retinoblastoma protein.

Phosphorylation (phosphorylation) of retinoblastoma protein associated with retinoblastoma

6) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2748684 Disease Relevance 0.53 Pain Relevance 0.08

PCNA and phosphorylated retinoblastoma protein (Figure 8A).

Phosphorylation (phosphorylated) of retinoblastoma protein associated with retinoblastoma

7) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2748684 Disease Relevance 0.31 Pain Relevance 0.03

B activation can therefore reduce cyclin D1 activity and subsequent phosphorylation of the retinoblastoma protein.

Phosphorylation (phosphorylation) of retinoblastoma protein associated with retinoblastoma

8) Confidence 0.01 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2745153 Disease Relevance 0.57 Pain Relevance 0.44

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