INT116116

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Context Info
Confidence 0.56
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.18
Pain Relevance 1.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CDK4) nucleoplasm (CDK4) signal transduction (CDK4)
nucleolus (CDK4) nucleus (CDK4) cell cycle (CDK4)
CDK4 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 141 98.22 Very High Very High Very High
Pain 2 63.72 Quite High
Inflammation 1 43.76 Quite Low
Opioid 13 5.00 Very Low Very Low Very Low
narcan 9 5.00 Very Low Very Low Very Low
opioid receptor 8 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
Enkephalin 2 5.00 Very Low Very Low Very Low
Endogenous opioid 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Retinoblastoma 27 99.84 Very High Very High Very High
Breast Cancer 2 99.20 Very High Very High Very High
Cancer 56 91.24 High High
Reprotox - General 1 4 82.60 Quite High
Squamous Cell Carcinoma 1 81.56 Quite High
Apoptosis 9 74.00 Quite High
Stomach Cancer 2 65.12 Quite High
Pain 2 63.72 Quite High
Anaplastic Astrocytoma 1 63.68 Quite High
Esophageal Cancer 1 63.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although phospho-Rb (pSer807/811) was specifically phosphorylated by Cdk4 in the G1 phase [12], OGF treatment did not alter the results of Western blot analysis of phospho-Rb (pSer807/811) levels (Fig. 2B).
Phosphorylation (phosphorylated) of Cdk4 associated with retinoblastoma
1) Confidence 0.56 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2253554 Disease Relevance 0.82 Pain Relevance 0
Capsaicin-induced G1 arrest is correlated with the suppression of cyclin D1 levels, inhibition of cdk4 activity and Rb phosphorylation in endothelial and breast cancer cells [21], [22].
Phosphorylation (phosphorylation) of cdk4 associated with qutenza and breast cancer
2) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2857654 Disease Relevance 1.05 Pain Relevance 0.71
This effect correlated with the down-regulation of the expression of cyclin D1 that led to inhibition of cyclin-dependent kinase 4-mediated phosphorylation of retinoblastoma protein.
Phosphorylation (phosphorylation) of cyclin-dependent kinase 4-mediated associated with retinoblastoma
3) Confidence 0.13 Published 2004 Journal Cancer Res. Section Abstract Doc Link 14744780 Disease Relevance 0.32 Pain Relevance 0.85

General Comments

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