INT116124

Context Info Confidence 0.20 First Reported 2004 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 1.72 Pain Relevance 0.15

transport (AFP) extracellular space (AFP) extracellular region (AFP) cytoplasm (AFP)

Anatomy Link Frequency thyroid 1 AFP (Homo sapiens) HCC (Homo sapiens)

Pain Link Frequency Relevance Heat Pain 2 83.80 imagery 3 77.60 palliative 1 5.00 fibrosis 1 5.00 nud 1 5.00

Disease Link Frequency Relevance Heat Hepatocellular Cancer 22 100.00 Cancer 30 97.20 Carcinoma 6 89.92 Thyroid Neoplasm 4 87.44 Recurrence 2 86.40 Liver Failure 1 85.20 Pain 2 83.80 Liver Cancer 1 77.36 Cholangiocarcinoma 2 75.00 Metastasis 15 63.04

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Immunohistochemically, HCC portion reacted positively with alpha-fetoprotein while CC portion demonstrated positive reactivity with carcinoembryonic antigen and mucicarmine.

alpha-fetoprotein Binding (reacted) of HCC

1) Confidence 0.20 Published 2004 Journal Korean J Gastroenterol Section Abstract Doc Link 14745254 Disease Relevance 0.76 Pain Relevance 0.08

In our case, the thyroid sample was negative for TTF-1, CK 7, and CK 20, but positive for alpha-fetoprotein, which is relatively specific for HCC, although of low sensitivity [14].

alpha-fetoprotein Binding (specific) of HCC in thyroid associated with hepatocellular cancer

2) Confidence 0.13 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC2246133 Disease Relevance 0.96 Pain Relevance 0.07

General Comments

This test has worked.