INT11613

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Context Info
Confidence 0.53
First Reported 1989
Last Reported 1998
Negated 0
Speculated 1
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 0
Pain Relevance 4.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cck, Oxt) extracellular region (Cck, Oxt) response to stress (Oxt)
cytoplasm (Oxt)
Anatomy Link Frequency
neural lobe 2
neurohypophysis 2
Cck (Rattus norvegicus)
Oxt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Cholecystokinin 17 100.00 Very High Very High Very High
Morphine 8 99.92 Very High Very High Very High
Opioid 10 99.68 Very High Very High Very High
Dynorphin 4 99.40 Very High Very High Very High
narcan 33 99.02 Very High Very High Very High
opiate 1 90.72 High High
Kinase C 2 88.48 High High
antagonist 8 88.32 High High
Endogenous opioid 2 86.00 High High
Enkephalin 1 69.92 Quite High
Disease Link Frequency Relevance Heat
Stress 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To investigate whether naloxone-pretreatment modified the effect of morphine on CCK-induced oxytocin release, on Day 4 CCK was injected i.v. with or without morphine.
CCK Spec (whether) Positive_regulation (induced) of Localization (release) of oxytocin associated with narcan, cholecystokinin and morphine
1) Confidence 0.53 Published 1998 Journal Neuropharmacology Section Abstract Doc Link 9776384 Disease Relevance 0 Pain Relevance 1.50
Morphine at a dose of 0.1 mg/kg did not affect CCK-induced oxytocin release, whereas 1 mg/kg of morphine blocked this release in both saline- and naloxone-pretreated rats.
CCK Positive_regulation (induced) of Localization (release) of oxytocin associated with narcan, cholecystokinin and morphine
2) Confidence 0.53 Published 1998 Journal Neuropharmacology Section Abstract Doc Link 9776384 Disease Relevance 0 Pain Relevance 1.49
The results suggest that the opioid influence upon CCK-induced oxytocin release operates at the level of the neurosecretory terminals in the neurohypophysis rather than centrally.
CCK Positive_regulation (induced) of Localization (release) of oxytocin in neurohypophysis associated with opioid
3) Confidence 0.43 Published 1992 Journal Exp Brain Res Section Abstract Doc Link 1577106 Disease Relevance 0 Pain Relevance 0.67
Cholecystokinin, coreleased with oxytocin by neural lobe terminals, has been shown to have high-affinity receptors located in the NL and to stimulate secretion of both oxytocin and vasopressin.
Cholecystokinin Positive_regulation (stimulate) of Localization (secretion) of oxytocin in neural lobe associated with cholecystokinin
4) Confidence 0.27 Published 1989 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 2575930 Disease Relevance 0 Pain Relevance 0.52

General Comments

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