INT116131

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Context Info
Confidence 0.53
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.68
Pain Relevance 1.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Commd3) cellular_component (Commd3) biological_process (Commd3)
Anatomy Link Frequency
brain 1
skin 1
Commd3 (Mus musculus)
Pain Link Frequency Relevance Heat
Buprenorphine 115 100.00 Very High Very High Very High
cocaine 7 100.00 Very High Very High Very High
transdermal 43 88.92 High High
pruritus 3 69.44 Quite High
Analgesic 42 59.88 Quite High
Neuropathic pain 8 49.80 Quite Low
Pain 93 48.68 Quite Low
Pain management 6 38.92 Quite Low
Lasting pain 17 6.96 Low Low
Morphine 32 5.76 Low Low
Disease Link Frequency Relevance Heat
Convulsion 2 90.80 High High
Malignant Neoplastic Disease 4 88.96 High High
Dermatitis 1 79.36 Quite High
Erythema 7 78.56 Quite High
Pruritus 4 69.44 Quite High
Pain 121 50.00 Quite Low
Neuropathic Pain 17 49.80 Quite Low
Cancer 36 12.40 Low Low
Adhesions 1 12.24 Low Low
Cognitive Disorder 1 9.04 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although statistically significant modifications in the expression of cocaine- or BUP-related brain-region-specific genes were not proved using whole cerebrums, including many unknown genes, our results suggest that the expression of genes related to neuronal cell damage, including non-peculiar genes related to the damage accompanying convulsive seizures and malignant tumors, were normalized and the genes related to the protection of neural cells were induced by BUP.
Gene_expression (expression) of BUP in brain associated with malignant neoplastic disease, convulsion, buprenorphine and cocaine
1) Confidence 0.53 Published 2004 Journal J Appl Toxicol Section Abstract Doc Link 14745842 Disease Relevance 0.27 Pain Relevance 0.83
In another study, the skin irritation potential of a single application of FEN TDS and BUP TDS patches was compared in healthy volunteers.87 46 healthy males and females (mean age [range]: 59.6 [50 to 69] years) with healthy skin received a single dose of both the FEN TDS 25 ?
Gene_expression (patches) of BUP in skin
2) Confidence 0.26 Published 2009 Journal Journal of pain research Section Body Doc Link PMC3004620 Disease Relevance 0.41 Pain Relevance 0.38

General Comments

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