INT116134

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Context Info
Confidence 0.28
First Reported 2004
Last Reported 2007
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 0.59
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (CREB1) signal transduction (CREB1) mitochondrion (CREB1)
nucleolus (CREB1) nucleus (CREB1) transcription factor binding (CREB1)
Anatomy Link Frequency
neuronal 4
CREB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
tolerance 1 99.52 Very High Very High Very High
addiction 4 98.96 Very High Very High Very High
opiate 1 97.52 Very High Very High Very High
intrathecal 2 68.00 Quite High
Inflammatory mediators 7 62.20 Quite High
Inflammatory response 10 50.00 Quite Low
Spinal cord 24 33.12 Quite Low
agonist 8 15.84 Low Low
antagonist 30 13.76 Low Low
Inflammation 41 12.68 Low Low
Disease Link Frequency Relevance Heat
Neuroblastoma 44 75.16 Quite High
Drug Dependence 1 75.00 Quite High
INFLAMMATION 59 61.80 Quite High
Lung Cancer 4 38.60 Quite Low
Interstitial Cystitis 26 5.00 Very Low Very Low Very Low
Disease 9 5.00 Very Low Very Low Very Low
Inflammatory Pain 9 5.00 Very Low Very Low Very Low
Hyperalgesia 7 5.00 Very Low Very Low Very Low
Neuropathic Pain 6 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the absence of PKA inhibitors, isoproterenol increased the phosphorylation state of CREB within 5 min returning to basal after 60 min (n = 3).
Positive_regulation (increased) of Positive_regulation (state) of CREB
1) Confidence 0.28 Published 2005 Journal Cell Commun Signal Section Body Doc Link PMC1198236 Disease Relevance 0.12 Pain Relevance 0.06
For neuronal cells, it has been suggested that a subpopulation of classical RAR receptors, localized at or near the cell membrane, could be responsible for ATRA-induced CREB (cyclic AMP-response-element-binding protein) activation through ERK1/2 phosphorylation [14].
Positive_regulation (induced) of Positive_regulation (activation) of CREB in neuronal
2) Confidence 0.24 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC1769480 Disease Relevance 0.20 Pain Relevance 0.03
For neuronal cells, it has been suggested that a subpopulation of classical RAR receptors, localized at or near the cell membrane, could be responsible for ATRA-induced CREB (cyclic AMP-response-element-binding protein) activation through ERK1/2 phosphorylation [14].
Positive_regulation (induced) of Positive_regulation (activation) of cyclic AMP-response-element-binding protein in neuronal
3) Confidence 0.24 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC1769480 Disease Relevance 0.20 Pain Relevance 0.03
This upregulation and the resulting activation of the transcription factor CREB appear to mediate aspects of tolerance and dependence.
Spec (appear) Positive_regulation (mediate) of Positive_regulation (activation) of CREB associated with addiction and tolerance
4) Confidence 0.17 Published 2004 Journal Annu. Rev. Med. Section Abstract Doc Link 14746512 Disease Relevance 0.07 Pain Relevance 0.32

General Comments

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