INT116140

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Context Info
Confidence 0.57
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.94
Pain Relevance 0.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Ddit3) cell cycle (Ddit3) DNA binding (Ddit3)
transcription factor binding (Ddit3) cytoplasm (Ddit3)
Anatomy Link Frequency
nucleus 1
reticulum 1
Ddit3 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 12 91.28 High High
Inflammation 70 60.92 Quite High
Inflammatory stimuli 6 52.88 Quite High
cytokine 4 48.40 Quite Low
anesthesia 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 59 99.62 Very High Very High Very High
Aging 2 95.08 Very High Very High Very High
Apoptosis 8 90.72 High High
Death 8 76.08 Quite High
Injury 4 75.00 Quite High
Nephrotoxicity 2 68.92 Quite High
Muscular Dystrophy 2 68.40 Quite High
Chronic Renal Failure 1 63.24 Quite High
INFLAMMATION 58 60.92 Quite High
Necrosis 4 59.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The authors also detected induction of endoplasmic reticulum (ER) stress, characterized by GADD153 upregulation and translocation to the nucleus, as well as caspase-12 cleavage.
Localization (translocation) of GADD153 in reticulum associated with stress
1) Confidence 0.57 Published 2004 Journal J. Am. Soc. Nephrol. Section Abstract Doc Link 14747384 Disease Relevance 1.07 Pain Relevance 0.90
In addition, regenerating myofibers showed nuclear and cytosolic staining for CHOP, whose nuclear translocation was described to occur during both in vitro and in vivo differentiation of murine myogenic cells [38,39].
Localization (translocation) of CHOP
2) Confidence 0.27 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888201 Disease Relevance 0.76 Pain Relevance 0.06
Some of the Grp94-positive and calreticulin-positive myotubes also displayed strong labeling for CHOP [30], whose staining localized either in the nucleus (thick arrowhead), in the cytosol (thick arrow), or at both locations (single arrowhead) (Figure 1f; compare with Additional file 2A).
Localization (localized) of CHOP in nucleus
3) Confidence 0.22 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888201 Disease Relevance 0.11 Pain Relevance 0

General Comments

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