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Context Info
Confidence 0.78
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.04
Pain Relevance 0.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Diablo) mitochondrion (Diablo) cytoplasm (Diablo)
Anatomy Link Frequency
pores 1
Diablo (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 12 99.12 Very High Very High Very High
Inflammation 29 50.00 Quite Low
cytokine 13 5.00 Very Low Very Low Very Low
Kinase C 10 5.00 Very Low Very Low Very Low
bradykinin 3 5.00 Very Low Very Low Very Low
spinal inflammation 2 5.00 Very Low Very Low Very Low
COX2 1 5.00 Very Low Very Low Very Low
COX-2 inhibitor 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 95 99.52 Very High Very High Very High
Death 16 89.60 High High
Nephrotoxicity 2 82.44 Quite High
Stress 34 80.24 Quite High
Injury 7 78.68 Quite High
Chronic Renal Failure 1 76.76 Quite High
INFLAMMATION 29 50.00 Quite Low
Shock 1 42.72 Quite Low
Diabetes Mellitus 83 13.92 Low Low
Increased Venous Pressure Under Development 19 12.88 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The mitochondrial pathway was not activated during paracetamol-induced apoptosis; there was no dissipation of mitochondrial potential or release of apoptogenic factors such as cytochrome c or Smac/DIABLO.
Localization (release) of DIABLO associated with paracetamol and apoptosis
1) Confidence 0.78 Published 2004 Journal J. Am. Soc. Nephrol. Section Abstract Doc Link 14747384 Disease Relevance 1.07 Pain Relevance 0.89
The mitochondria contains proapoptotic proteins such as Apoptosis Inducing Factor (AIF), Smac/DIABLO, and cytochrome C, which are released through these pores, which in turn leads to the formation of the apoptosome and the activation of the caspase cascade [27, 28].
Localization (released) of Smac in pores associated with apoptosis
2) Confidence 0.68 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2903979 Disease Relevance 0.97 Pain Relevance 0

General Comments

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