INT116143

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Context Info
Confidence 0.67
First Reported 2003
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 32
Total Number 35
Disease Relevance 30.34
Pain Relevance 3.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Casp9) peptidase activity (Casp9) mitochondrion (Casp9)
nucleus (Casp9) cytoplasm (Casp9)
Anatomy Link Frequency
poly 3
cleavage 2
primary neurons 1
T cell 1
MDA-MB-231 1
Casp9 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 13 98.72 Very High Very High Very High
aspirin 16 97.72 Very High Very High Very High
fortral 4 91.48 High High
agonist 3 90.88 High High
withdrawal 5 86.96 High High
cva 76 85.28 High High
antagonist 9 84.80 Quite High
cINOD 33 83.84 Quite High
COX-2 inhibitor 110 79.28 Quite High
chemokine 64 75.00 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 1228 100.00 Very High Very High Very High
Death 352 99.62 Very High Very High Very High
Atrophy 9 99.36 Very High Very High Very High
Hemorrhagic Shock 153 99.28 Very High Very High Very High
Alagille Syndrome 4 99.28 Very High Very High Very High
Infection 96 98.68 Very High Very High Very High
Injury 114 98.64 Very High Very High Very High
Carcinoma 116 97.76 Very High Very High Very High
Cancer 540 97.30 Very High Very High Very High
Disease 174 97.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results showed that administration of indomethacin to PiZ mice resulted in increased hepatic injury, indicated by increased hepatocellular proliferation and increased activation of caspase 9.
Positive_regulation (activation) of caspase 9 associated with injury
1) Confidence 0.67 Published 2006 Journal Hepatology Section Abstract Doc Link 17006946 Disease Relevance 1.13 Pain Relevance 0.23
Finally, we have shown that aspirin treatment caused changes in the mitochondrial membrane potential, release of cytochrome c from mitochondria, and activation of caspase-9 and -3, which could be because of the proteasomal dysfunction.
Positive_regulation (activation) of caspase-9 associated with aspirin
2) Confidence 0.49 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16880202 Disease Relevance 0.52 Pain Relevance 0.32
The released cytochrome c binds to the apoptosis protease-activating factor-1 (Apaf-1), and this complex activates caspase-9.
Positive_regulation (activates) of caspase-9 associated with apoptosis
3) Confidence 0.36 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2978204 Disease Relevance 0.97 Pain Relevance 0
However, paracetamol-induced apoptosis is a caspase-dependent process that involves activation of caspase-9 and caspase-3 in the absence of cytosolic cytochrome c or Smac/DIABLO.
Positive_regulation (activation) of caspase-9 associated with paracetamol and apoptosis
4) Confidence 0.36 Published 2004 Journal J. Am. Soc. Nephrol. Section Abstract Doc Link 14747384 Disease Relevance 1.10 Pain Relevance 0.91
Our analyses of HS-induced apoptotic changes in splenocytes indicated a biphasic activation of caspase-9 with a corresponding increase of pro-apoptotic Bax and repressed anti-apoptotic Bcl-2 protein expression.
Positive_regulation (activation) of caspase-9 associated with apoptosis and hemorrhagic shock
5) Confidence 0.27 Published 2008 Journal Crit Care Section Body Doc Link PMC2374615 Disease Relevance 1.33 Pain Relevance 0.03
Significantly elevated activities of caspase-3, caspase-8 and caspase-9 were observed in BJMC3879luc2 cells treated with raloxifene for 24 h (Figure 2B) and 48 h (data not shown), as compared to the respective controls.
Positive_regulation (activities) of caspase-9
6) Confidence 0.26 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2978204 Disease Relevance 0.45 Pain Relevance 0
Antisense suppression of GADD45alpha expression significantly reduced sulindac and indomethacin-induced activation of caspase-9 and apoptosis in AGS cells.
Positive_regulation (activation) of caspase-9 in AGS associated with alagille syndrome and apoptosis
7) Confidence 0.22 Published 2010 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 20498252 Disease Relevance 1.40 Pain Relevance 0.25
or intrinsic mitochondria-induced release of cytochrome c with subsequent activation of caspase-9 and caspase-3, respectively [24].
Positive_regulation (activation) of caspase-9
8) Confidence 0.20 Published 2008 Journal Crit Care Section Body Doc Link PMC2374615 Disease Relevance 1.29 Pain Relevance 0.09
Conversely, there were no significant differences in the protein content of caspase 9, cleaved caspase 9 or the ratio of cleaved caspase 9/caspase 9.
Positive_regulation (cleaved) of caspase 9
9) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827549 Disease Relevance 0.85 Pain Relevance 0.03
Conversely, there were no significant differences in the protein content of caspase 9, cleaved caspase 9 or the ratio of cleaved caspase 9/caspase 9.
Positive_regulation (cleaved) of caspase 9
10) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827549 Disease Relevance 0.85 Pain Relevance 0.03
Thereby, HS animals demonstrated significantly increased caspase-3/7, caspase-8, and caspase-9 activities at t = 0 hours and t = 72 hours in splenic tissue when compared with the appropriate sham-operated or control animals (Figure 2c).
Positive_regulation (increased) of caspase-9 associated with hemorrhagic shock
11) Confidence 0.18 Published 2008 Journal Crit Care Section Body Doc Link PMC2374615 Disease Relevance 1.15 Pain Relevance 0.12
The increase in cleaved caspase 9 protein content signifies an elevation in apoptosis in the later stages of the disease.
Positive_regulation (increase) of caspase 9 protein associated with disease and apoptosis
12) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827549 Disease Relevance 0.64 Pain Relevance 0
The fact that the ADH transgene augmented the ethanol-induced cytosolic accumulation of pro-caspase-9 and cytochrome C further substantiated the critical role of acetaldehyde in ethanol-induced mitochondrial damage, which is consistent with the ADH-accentuated mitochondrial O2•?
Positive_regulation (accumulation) of pro-caspase-9
13) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2807457 Disease Relevance 1.39 Pain Relevance 0.06
inhibitors prevented MPP+-induced caspase-9 and caspase-3 activation
Positive_regulation (activation) of caspase-9
14) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2675062 Disease Relevance 0.26 Pain Relevance 0
The MPP+ treatment induced a significant activation of caspase-9 in both neuronal models as compared to the untreated control, the maximal significant effect being observed after a 2 h-treatment for TSM1 cells and a 1 h-treatment for primary neurons (129.37±11.61% and 165.80±10.92% compared to the control conditions taken as 100%, Figure 3A and 3D).
Positive_regulation (activation) of caspase-9 in primary neurons
15) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2675062 Disease Relevance 0.23 Pain Relevance 0
This, in turn, activates successively caspase-9 and caspase-3, accompanied by poly (ADP-ribose) polymerase (PARP) cleavage [46], [49], [50], [51].
Positive_regulation (activates) of caspase-9 in cleavage
16) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2675062 Disease Relevance 1.23 Pain Relevance 0.03
To further characterize the intracellular pathways involved in the cell death induced by MPP+, we examined by fluorimetric assays and Western blot the activation of caspase-9 and caspase-3 after incubation with MPP+ in the presence or in the absence of pre-treatment with LiCl and kenpaullone (Figure 3).
Spec (examined) Positive_regulation (activation) of caspase-9 associated with death
17) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2675062 Disease Relevance 0.25 Pain Relevance 0
In a similar experiment (Figure 5) MCT cells treated with HgCl2 with and without VLP-pretreatment, were analyzed for the activation of caspase 9 (as indicated by its autocleavage to 35 kDa) and activation of caspase 3 (auto-cleaved to 17 kDa fragment).
Spec (analyzed) Positive_regulation (activation) of caspase 9
18) Confidence 0.09 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2515219 Disease Relevance 0.28 Pain Relevance 0
It suppresses the expression of cyclin D1, which is deregulated in several types of tumor, and it also induces apoptosis in tumor cells by activating caspase-8, which leads to cleavage of Bid, thus resulting in sequential release of mitochondrial cytochrome c and activation of caspase-9 and caspase-3, cleavage of poly ADP ribose polymerase (PARP) and apoptosis of tumor cells.
Positive_regulation (activation) of caspase-9 in poly associated with cancer and apoptosis
19) Confidence 0.08 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2898702 Disease Relevance 1.10 Pain Relevance 0.07
To monitor the change in mitochondrial death domain, cytosolic accumulation of pro-caspase-9, cytochrome C and apoptosis inducing factor (AIF) was examined.
Positive_regulation (accumulation) of pro-caspase-9 associated with apoptosis and death
20) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2807457 Disease Relevance 1.18 Pain Relevance 0

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