INT116144

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Context Info
Confidence 0.41
First Reported 2004
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.95
Pain Relevance 1.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Ddit3) cell cycle (Ddit3) DNA binding (Ddit3)
transcription factor binding (Ddit3) cytoplasm (Ddit3)
Anatomy Link Frequency
reticulum 2
Ddit3 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 12 92.60 High High
Glutamate receptor 1 91.72 High High
Glutamate 2 86.52 High High
Neurotransmitter 1 84.36 Quite High
excitatory amino acid 2 83.16 Quite High
nMDA receptor 2 57.44 Quite High
ischemia 5 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
isoflurane 3 5.00 Very Low Very Low Very Low
nMDA receptor antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 60 100.00 Very High Very High Very High
Death 33 98.44 Very High Very High Very High
Apoptosis 18 98.00 Very High Very High Very High
Drug Induced Neurotoxicity 3 80.88 Quite High
Neurodegenerative Disease 2 76.16 Quite High
Injury 5 75.00 Quite High
Retinal Vein Occlusion 1 74.08 Quite High
Diabetic Retinopathy 1 72.96 Quite High
Disease 3 71.76 Quite High
Nephrotoxicity 2 71.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The authors also detected induction of endoplasmic reticulum (ER) stress, characterized by GADD153 upregulation and translocation to the nucleus, as well as caspase-12 cleavage.
Positive_regulation (induction) of Positive_regulation (upregulation) of GADD153 in reticulum associated with stress
1) Confidence 0.41 Published 2004 Journal J. Am. Soc. Nephrol. Section Abstract Doc Link 14747384 Disease Relevance 1.09 Pain Relevance 0.92
They demonstrated to be caused by an accumulation of polyubiquitinated proteins and increases in X box binding protein (XBP-1) mRNA splicing and C/EBP-homologous (CHOP) mRNA, representing activation of the unfolded-protein response (UPR) signaling pathway.
Positive_regulation (accumulation) of Positive_regulation (increases) of CHOP
2) Confidence 0.38 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2652022 Disease Relevance 1.86 Pain Relevance 0.28

General Comments

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