INT116148

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Context Info
Confidence 0.48
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 3.35
Pain Relevance 1.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Casp12) peptidase activity (Casp12) endoplasmic reticulum (Casp12)
nucleus (Casp12) intracellular (Casp12)
Anatomy Link Frequency
reticulum 2
Casp12 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 20 99.16 Very High Very High Very High
anesthesia 5 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
isoflurane 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
agonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 10 100.00 Very High Very High Very High
Apoptosis 41 98.28 Very High Very High Very High
Death 8 96.56 Very High Very High Very High
Cancer 86 85.76 High High
Carcinoma 19 80.88 Quite High
Injury 4 79.56 Quite High
Shock 3 76.56 Quite High
Nephrotoxicity 2 71.52 Quite High
Endometrial Cancer 5 71.36 Quite High
Body Weight 7 67.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Genes important for sequential activation of caspases cascade Casp12, Casp7, Prf1, Gzmb were also down-regulated in mice fed with HF diet, however the apoptosis inhibitor proteins Birc2, Birc5 were suppressed.
Positive_regulation (activation) of Casp12 associated with apoptosis
1) Confidence 0.48 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2674043 Disease Relevance 0.50 Pain Relevance 0
The authors also detected induction of endoplasmic reticulum (ER) stress, characterized by GADD153 upregulation and translocation to the nucleus, as well as caspase-12 cleavage.
Positive_regulation (induction) of caspase-12 in reticulum associated with stress
2) Confidence 0.38 Published 2004 Journal J. Am. Soc. Nephrol. Section Abstract Doc Link 14747384 Disease Relevance 1.10 Pain Relevance 0.93
Transient activation of the ER-resident caspase-12 was shown followed by an elevation in procaspase-12 level.
Positive_regulation (activation) of caspase-12
3) Confidence 0.30 Published 2007 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 17207453 Disease Relevance 0.43 Pain Relevance 0.65
In the present study, since no elevation in caspase-12 activity was seen, the raloxifene-induced apoptosis may not have involved endoplasmic reticulum stress.
Neg (no) Positive_regulation (elevation) of caspase-12 in reticulum associated with stress and apoptosis
4) Confidence 0.11 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2978204 Disease Relevance 1.32 Pain Relevance 0

General Comments

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