INT116150

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Context Info
Confidence 0.67
First Reported 2004
Last Reported 2009
Negated 2
Speculated 0
Reported most in Body
Documents 26
Total Number 26
Disease Relevance 22.58
Pain Relevance 5.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Ddit3) cell cycle (Ddit3) DNA binding (Ddit3)
transcription factor binding (Ddit3) cytoplasm (Ddit3)
Anatomy Link Frequency
retina 3
liver 2
stem cell 2
colon 1
apoptotic cell 1
Ddit3 (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 25 99.96 Very High Very High Very High
diclofenac 14 99.72 Very High Very High Very High
nMDA receptor antagonist 18 99.68 Very High Very High Very High
Paracetamol 23 96.64 Very High Very High Very High
agonist 22 95.92 Very High Very High Very High
Inflammation 31 92.80 High High
Glutamate receptor 10 91.72 High High
Inflammatory response 25 87.56 High High
Glutamate 18 86.52 High High
chemokine 2 84.48 Quite High
Disease Link Frequency Relevance Heat
Stress 739 100.00 Very High Very High Very High
Colon Cancer 7 100.00 Very High Very High Very High
Mantle-cell Lymphoma 36 99.66 Very High Very High Very High
Death 404 99.58 Very High Very High Very High
Apoptosis 229 99.36 Very High Very High Very High
Cancer 91 99.36 Very High Very High Very High
Lung Cancer 1 99.28 Very High Very High Very High
Drug Induced Neurotoxicity 27 98.80 Very High Very High Very High
Ganglion Cysts 216 96.68 Very High Very High Very High
Hepatocellular Cancer 3 96.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Transcriptional activation and elevated expression of GADD153/CHOP, an ER stress-responsive proapoptotic transcription factor, was observed upon AAP addition.
Positive_regulation (activation) of GADD153 associated with stress and paracetamol
1) Confidence 0.67 Published 2007 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 17207453 Disease Relevance 0.42 Pain Relevance 0.58
NSAIDs other than indomethacin (diclofenac, ibuprofen and celecoxib) also induced CHOP.
Positive_regulation (induced) of CHOP associated with cinod and diclofenac
2) Confidence 0.62 Published 2004 Journal Cell Death Differ. Section Abstract Doc Link 15131590 Disease Relevance 0.86 Pain Relevance 0.67
The translation of the ATF4 transcription factor is positively regulated by PERK activation in cultured fibroblasts subjected to ER-stress and results in the transcriptional upregulation of GADD153/CHOP.
Positive_regulation (upregulation) of CHOP in fibroblasts associated with stress
3) Confidence 0.60 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC2072952 Disease Relevance 0.29 Pain Relevance 0.07
CHOP upregulation is distal to both PERK and ATF4 activation and is generally considered to be pro-apoptotic, however, like caspase activation; it may also have a role in oncosis under certain circumstances [28].
Positive_regulation (upregulation) of CHOP associated with apoptosis
4) Confidence 0.60 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC2072952 Disease Relevance 0.54 Pain Relevance 0.04
The authors also detected induction of endoplasmic reticulum (ER) stress, characterized by GADD153 upregulation and translocation to the nucleus, as well as caspase-12 cleavage.
Positive_regulation (upregulation) of GADD153 in reticulum associated with stress
5) Confidence 0.56 Published 2004 Journal J. Am. Soc. Nephrol. Section Abstract Doc Link 14747384 Disease Relevance 1.07 Pain Relevance 0.90
Increases in GRP78/BiP and CHOP in mouse retina after NMDA injection
Positive_regulation (Increases) of CHOP in retina
6) Confidence 0.56 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2652022 Disease Relevance 0.51 Pain Relevance 0
They demonstrated to be caused by an accumulation of polyubiquitinated proteins and increases in X box binding protein (XBP-1) mRNA splicing and C/EBP-homologous (CHOP) mRNA, representing activation of the unfolded-protein response (UPR) signaling pathway.
Positive_regulation (accumulation) of CHOP
7) Confidence 0.56 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2652022 Disease Relevance 1.86 Pain Relevance 0.28
Since CHOP is a member of the CCAAT/enhancer-binding protein family that is induced by ER stress and participates in ER-mediated apoptosis, CHOP may be a key molecule in retinal cell death [17].
Positive_regulation (induced) of CHOP associated with stress, apoptosis and death
8) Confidence 0.56 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2652022 Disease Relevance 1.02 Pain Relevance 0
Furthermore, Awai et al. [30] found that treatment with MK-801, an NMDA receptor antagonist, inhibited the increases in CHOP mRNA and protein in the mouse retina that are observed after intravitreal injection of NMDA, and moreover that CHOP-deficient mice were resistant to NMDA-induced retinal damage.
Positive_regulation (increases) of CHOP mRNA in retina associated with nmda receptor antagonist
9) Confidence 0.56 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2652022 Disease Relevance 0.97 Pain Relevance 0.08
Comparison of CHOP expression between isolated microglia and mixed glial cultures showed that constitutive CHOP expression levels were much higher in the mixed glia, and could be further elevated by thapsigargin treatment.
Positive_regulation (elevated) of CHOP in microglia
10) Confidence 0.49 Published 2006 Journal Retrovirology Section Body Doc Link PMC1475625 Disease Relevance 0.74 Pain Relevance 0
As shown in figure 2, panel A, no induction of the ER stress genes BiP, CHOP, calreticulin or Grp58 was observed in FrCasE-infected microglial cultures when compared with mock or Fr57E-infected cells.
Neg (no) Positive_regulation (induction) of CHOP associated with stress
11) Confidence 0.49 Published 2006 Journal Retrovirology Section Body Doc Link PMC1475625 Disease Relevance 0.66 Pain Relevance 0.07
Furthermore, ER stress-inducible genes, such as Atf4, Gadd34/Myd116, and Ddit3/CHOP, are up-regulated in the liver after high-dose methapyrilene administration.
Positive_regulation (inducible) of CHOP in liver associated with stress
12) Confidence 0.45 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1852695 Disease Relevance 1.21 Pain Relevance 0.10
The levels of the JNK-regulated proapoptotic transcription factor C/EBP homologous protein (CHOP) were also increased after DCF.
Positive_regulation (increased) of CHOP associated with diclofenac
13) Confidence 0.45 Published 2009 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 20501447 Disease Relevance 0.82 Pain Relevance 0.73
Exposure of cells to indomethacin, a commonly used NSAID, induced GRP78 as well as CHOP, a transcription factor involved in apoptosis.
Positive_regulation (induced) of CHOP associated with cinod and apoptosis
14) Confidence 0.42 Published 2004 Journal Cell Death Differ. Section Abstract Doc Link 15131590 Disease Relevance 0.91 Pain Relevance 0.64
Since CHOP is a member of the CCAAT/enhancer-binding protein family that is induced by ER stress and participates in ER-mediated apoptosis, CHOP may be a key molecule in retinal cell death [17].
Positive_regulation (induced) of CHOP associated with stress, apoptosis and death
15) Confidence 0.40 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2652022 Disease Relevance 1.02 Pain Relevance 0
On the other hand, we found that staurosporine, which mediates mitochondrial dysfunctions resulting in apoptotic cell death, did not induce any increases in BiP and CHOP proteins in RGC-5 [unpublished data].
Neg (not) Positive_regulation (increases) of CHOP in apoptotic cell associated with apoptosis and death
16) Confidence 0.38 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2652022 Disease Relevance 1.16 Pain Relevance 0
BiP and CHOP were increased at 12 h after NMDA injection, and the increases persisted for the remainder of the 72 h observation period.


Positive_regulation (increased) of CHOP
17) Confidence 0.38 Published 2007 Journal Molecular Vision Section Abstract Doc Link PMC2652022 Disease Relevance 0.97 Pain Relevance 0
They demonstrated to be caused by an accumulation of polyubiquitinated proteins and increases in X box binding protein (XBP-1) mRNA splicing and C/EBP-homologous (CHOP) mRNA, representing activation of the unfolded-protein response (UPR) signaling pathway.
Positive_regulation (increases) of CHOP
18) Confidence 0.38 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2652022 Disease Relevance 1.77 Pain Relevance 0.28
Collectively, the above results indicate that NMDA can cause ER stress in the retina, and that the neurotoxicity induced by NMDA is due in part to a mechanism dependent on CHOP protein induction through excessive ER stress.
Positive_regulation (induction) of CHOP in retina associated with stress and drug induced neurotoxicity
19) Confidence 0.38 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2652022 Disease Relevance 1.06 Pain Relevance 0.04
Furthermore, ER stress-inducible genes, such as Atf4, Gadd34/Myd116, and Ddit3/CHOP, are up-regulated in the liver after high-dose methapyrilene administration.
Positive_regulation (inducible) of Ddit3 in liver associated with stress
20) Confidence 0.20 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1852695 Disease Relevance 1.21 Pain Relevance 0.10

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