INT11616

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Context Info
Confidence 0.74
First Reported 1983
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 0.32
Pain Relevance 3.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Thop1) cytoplasm (Thop1)
Anatomy Link Frequency
cleavage 2
trigeminal ganglia 1
tail 1
epithelial cells 1
immune system 1
Thop1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
bradykinin 13 100.00 Very High Very High Very High
Neuropeptide 9 100.00 Very High Very High Very High
Enkephalin 27 99.84 Very High Very High Very High
Central nervous system 3 99.44 Very High Very High Very High
Antinociceptive 1 98.88 Very High Very High Very High
Analgesic 6 98.24 Very High Very High Very High
Eae 1 97.12 Very High Very High Very High
tail-flick 1 96.48 Very High Very High Very High
Neurotransmitter 1 93.00 High High
Cholecystokinin 2 91.44 High High
Disease Link Frequency Relevance Heat
Nociception 2 91.68 High High
Glioma 2 78.16 Quite High
Pain 1 77.20 Quite High
INFLAMMATION 1 73.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intraperitoneal administration of N-[1-(R,S)-carboxy-2-phenylethyl-Phe-p-aminobenzoate, synthesized in this laboratory as a potent inhibitor of membrane-bound metalloendopeptidase (EC 3.4.24.11) caused a prolonged but weak analgesic effect on rats as measured by the tail flick test.
Gene_expression (synthesized) of metalloendopeptidase in tail associated with analgesic and tail-flick
1) Confidence 0.74 Published 1984 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6383843 Disease Relevance 0 Pain Relevance 0.59
Expression of endo-oligopeptidase A in the rat central nervous system: a non-radioactive in situ hybridization study.
Gene_expression (Expression) of oligopeptidase in central nervous system associated with central nervous system
2) Confidence 0.63 Published 2001 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 11311978 Disease Relevance 0 Pain Relevance 0.39
Thimet oligopeptidase (M(r) 74000) is widely distributed in animals and plants.
Gene_expression (distributed) of Thimet oligopeptidase
3) Confidence 0.57 Published 1993 Journal Biol. Chem. Hoppe-Seyler Section Abstract Doc Link 8471182 Disease Relevance 0 Pain Relevance 0.08
Enkephalinase (EC 3.4.24.11, membrane metalloendopeptidase) is a zinc peptidase expressed by neurons and a variety of epithelial cells, and responsible for the inactivation of enkephalins in brain.
Gene_expression (expressed) of metalloendopeptidase in epithelial cells associated with enkephalin
4) Confidence 0.41 Published 1991 Journal Neuropeptides Section Abstract Doc Link 1716743 Disease Relevance 0 Pain Relevance 0.10
Presence of endo-oligopeptidase (EC 3.4.22.19), a putative neuropeptide-metabolizing endopeptidase in cells of the immune system.
Gene_expression (Presence) of endo-oligopeptidase in immune system associated with neuropeptide
5) Confidence 0.33 Published 1992 Journal J. Neuroimmunol. Section Title Doc Link 1577951 Disease Relevance 0 Pain Relevance 0.39
The relationships between various properties of inhibitors of enkephalinase (membrane metalloendopeptidase, EC 3.4.24.11) i.e., enzyme inhibition, protection of endogenous enkephalins, antinociceptive activity and stimulation of locomotor activity was investigated by comparing the relative potencies of the two enantiomers of Thiorphan and acetorphan, its parenterally active prodrug.
Gene_expression (protection) of metalloendopeptidase associated with eae, enkephalin and antinociceptive
6) Confidence 0.07 Published 1987 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3479550 Disease Relevance 0 Pain Relevance 0.27
Two aminopeptidases, involved in the cleavage of enkephalins, and a metalloendopeptidase were identified in extracts of solubilized synaptic membranes.
Gene_expression (identified) of metalloendopeptidase in cleavage associated with enkephalin
7) Confidence 0.06 Published 1983 Journal FEBS Lett. Section Abstract Doc Link 6132834 Disease Relevance 0 Pain Relevance 0.42
Endo-oligopeptidase A known to hydrolyse the Phe5-Ser6 bond of bradykinin and the Arg8-Arg9 bond of neurotensin has been shown to produce, by a single cleavage, leucine5-enkephalin from small prodynorphin derived enkephalin-containing peptides.
Gene_expression (produce) of Endo-oligopeptidase in cleavage associated with enkephalin and bradykinin
8) Confidence 0.06 Published 1986 Journal NIDA Res. Monogr. Section Abstract Doc Link 3123940 Disease Relevance 0 Pain Relevance 0.33
Western blot analysis of crude subcellular fractions and lipid raft preparations of cultured rat trigeminal ganglia demonstrate similar expression profiles between EP24.15/16 and B2R on a subcellular level.
Gene_expression (expression) of EP24 in trigeminal ganglia
9) Confidence 0.04 Published 2006 Journal J. Neurochem. Section Abstract Doc Link 16515556 Disease Relevance 0.24 Pain Relevance 0.60
The metalloendopeptidase 24.15 (EP24.15) is ubiquitously present in the extracellular environment as a secreted protein.
Gene_expression (present) of metalloendopeptidase 24.15
10) Confidence 0.01 Published 2005 Journal FEBS J. Section Abstract Doc Link 15955058 Disease Relevance 0.08 Pain Relevance 0.17

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