INT116163

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.78
First Reported 2004
Last Reported 2010
Negated 5
Speculated 0
Reported most in Body
Documents 29
Total Number 29
Disease Relevance 14.11
Pain Relevance 7.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (S1pr1) plasma membrane (S1pr1) signal transducer activity (S1pr1)
Anatomy Link Frequency
renal proximal tubule 2
plasma 1
CSF 1
cerebellum 1
hippocampus 1
S1pr1 (Mus musculus)
Pain Link Frequency Relevance Heat
isoflurane 42 99.70 Very High Very High Very High
Arthritis 448 99.52 Very High Very High Very High
allodynia 35 99.52 Very High Very High Very High
Hippocampus 8 99.52 Very High Very High Very High
Inflammation 347 99.32 Very High Very High Very High
Multiple sclerosis 19 98.62 Very High Very High Very High
agonist 129 97.44 Very High Very High Very High
cytokine 118 96.32 Very High Very High Very High
Thermal hyperalgesia 5 95.40 Very High Very High Very High
Inflammatory response 35 93.24 High High
Disease Link Frequency Relevance Heat
Hypertension 9 99.80 Very High Very High Very High
Carcinoma 12 99.66 Very High Very High Very High
Arthritis 434 99.52 Very High Very High Very High
Neuropathic Pain 146 99.52 Very High Very High Very High
Heart Rate Under Development 4 99.46 Very High Very High Very High
Systemic Sclerosis 10 99.34 Very High Very High Very High
INFLAMMATION 180 99.32 Very High Very High Very High
Demyelinating Disease 64 98.62 Very High Very High Very High
Asthma 20 96.96 Very High Very High Very High
Apoptosis 390 95.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed, inhalation of inhibitors for sphingosine kinase (SphK), which produces S1P directly from sphingosine, attenuated antigen-induced airway inflammation in mice [9].
Gene_expression (produces) of S1P associated with inflammation
1) Confidence 0.78 Published 2010 Journal The Open Respiratory Medicine Journal Section Body Doc Link PMC3024555 Disease Relevance 1.31 Pain Relevance 0.21
We sought to determine whether isoflurane stimulates sphingosine kinase (SK) activity and synthesis of sphingosine-1-phosphate (S1P) in renal proximal tubule cells to mediate renal protection via the S1P signaling pathway.
Gene_expression (synthesis) of S1P in renal proximal tubule associated with isoflurane
2) Confidence 0.74 Published 2007 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 17898040 Disease Relevance 0.66 Pain Relevance 0.57
We sought to determine whether isoflurane stimulates sphingosine kinase (SK) activity and synthesis of sphingosine-1-phosphate (S1P) in renal proximal tubule cells to mediate renal protection via the S1P signaling pathway.
Gene_expression (synthesis) of sphingosine-1-phosphate in renal proximal tubule associated with isoflurane
3) Confidence 0.74 Published 2007 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 17898040 Disease Relevance 0.66 Pain Relevance 0.56
Immunolocalization of S1P(3) in rodent heart revealed abundant expression on myocytes and perivascular smooth muscle cells consistent with regulation of bradycardia and hypertension, whereas S1P(1) expression was restricted to the vascular endothelium.
Gene_expression (expression) of S1P in myocytes associated with heart rate under development and hypertension
4) Confidence 0.67 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14747617 Disease Relevance 1.01 Pain Relevance 0.21
We hypothesize that during the course of multiple sclerosis (MS) development, chronic inflammation will result in the alteration of S1P levels in blood and cerebrospinal fluid (CSF).
Gene_expression (levels) of S1P in CSF associated with multiple sclerosis and inflammation
5) Confidence 0.61 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20434523 Disease Relevance 0.83 Pain Relevance 0.46
Finally, isoflurane increased the generation of S1P in HK-2 cells.
Gene_expression (generation) of S1P in HK-2 associated with isoflurane
6) Confidence 0.58 Published 2007 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 17898040 Disease Relevance 0.62 Pain Relevance 0.61
These cascade of events include the activation of sphingosine kinase (SK), and subsequent production of the mitogenic and proinflammatory lipid sphingosine 1-phosphate (S1P).
Gene_expression (production) of S1P
7) Confidence 0.53 Published 2010 Journal Carcinogenesis Section Abstract Doc Link 20688834 Disease Relevance 0.78 Pain Relevance 0.23
These cascade of events include the activation of sphingosine kinase (SK), and subsequent production of the mitogenic and proinflammatory lipid sphingosine 1-phosphate (S1P).
Gene_expression (production) of proinflammatory lipid sphingosine 1-phosphate
8) Confidence 0.47 Published 2010 Journal Carcinogenesis Section Abstract Doc Link 20688834 Disease Relevance 0.78 Pain Relevance 0.23
S1P is produced by the activation (i.e., phosphorylation) of sphingosine (Sph) via its 2 isoforms of sphingosine kinase-1/2 (SphK-1/2) resulting in the production of the prosurvival S1P molecule with decreasing levels of the proapoptotic Sph molecule [35].
Gene_expression (produced) of S1P
9) Confidence 0.45 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2842969 Disease Relevance 0.39 Pain Relevance 0.07
In addition, silencing of S1P(3) receptor expression (siRNA) abolished the permeability response to each edemagenic agonist.
Gene_expression (expression) of S1P associated with agonist
10) Confidence 0.41 Published 2007 Journal Am. J. Respir. Cell Mol. Biol. Section Abstract Doc Link 17395891 Disease Relevance 0 Pain Relevance 0.56
In the in vitro experiments, LPA and S1P were dissolved in Dulbecco's Modified Eagle's Medium (DMEM) with 0.1% fatty acid-free bovine serum albumin (A-6003 Sigma-Aldrich, St.
Gene_expression (dissolved) of S1P
11) Confidence 0.39 Published 2009 Journal Mol Pain Section Body Doc Link PMC2780384 Disease Relevance 0 Pain Relevance 0
S1P is produced by the activation (i.e., phosphorylation) of sphingosine (Sph) via its 2 isoforms of sphingosine kinase-1/2 (SphK-1/2) resulting in the production of the prosurvival S1P molecule with decreasing levels of the proapoptotic Sph molecule [35].
Gene_expression (production) of S1P
12) Confidence 0.39 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2842969 Disease Relevance 0.44 Pain Relevance 0.09
The discovery of promising specific targets for intervention in the inflammatory arthritis process have included, S1P, IL-7R, Syk, Raf/MEK/ERK 1/2, MK5/PRAK, miRNA, PI3K/PTEN/Akt, NF-?
Gene_expression (/) of S1P associated with inflammation and arthritis
13) Confidence 0.39 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2842969 Disease Relevance 1.00 Pain Relevance 0.64
Furthermore, genetic studies in mice expressing reduced levels of SPL showed decreased circulating lymphocytes as a result of alterations in lymphocyte trafficking and studies of lymphoid tissues following oral administration of 2-acetyl-4(5)-(1(R), 2(S), 3(R), 4-tetrahydroxybutyl)-imidazole, an experimental inhibitor of SPL, showed a clear relationship between reduced SPL activity, elevated S1P levels, and lower levels of circulating lymphocytes [40], thus supporting the targeting of S1P signaling as a potentially important antiinflammatory pathway [41].
Gene_expression (levels) of S1P in lymphocytes associated with inflammation
14) Confidence 0.39 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2842969 Disease Relevance 0.34 Pain Relevance 0.15
In that regard, several murine F9 embryonic carcinoma cell lines were produced with varying expressional levels of the S1P-degrading enzyme, S1P lyase (SPL) and/or SphK1 [39].
Gene_expression (produced) of S1P associated with carcinoma
15) Confidence 0.39 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2842969 Disease Relevance 0.43 Pain Relevance 0.17
In that regard, several murine F9 embryonic carcinoma cell lines were produced with varying expressional levels of the S1P-degrading enzyme, S1P lyase (SPL) and/or SphK1 [39].
Gene_expression (expressional) of S1P associated with carcinoma
16) Confidence 0.39 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2842969 Disease Relevance 0.43 Pain Relevance 0.17
The discovery of promising specific targets for intervention in the inflammatory arthritis process have included, S1P, IL-7R, Syk, Raf/MEK/ERK 1/2, MK5/PRAK, miRNA, PI3K/PTEN/Akt, NF-?
Gene_expression (/) of S1P associated with inflammation and arthritis
17) Confidence 0.39 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2842969 Disease Relevance 1.00 Pain Relevance 0.64
In addition, five S1P-specific receptors, S1P1, S1P2, S1P3, S1P4 and S1P5, belong to this gene cluster.
Gene_expression (belong) of S1P1
18) Confidence 0.31 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.05 Pain Relevance 0.03
A recent study using plasma and serum samples from systemic scleroderma patients found elevated LPA and S1P levels.
Gene_expression (levels) of S1P in plasma associated with systemic sclerosis
19) Confidence 0.31 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.86 Pain Relevance 0.27
In addition, five S1P-specific receptors, S1P1, S1P2, S1P3, S1P4 and S1P5, belong to this gene cluster.
Gene_expression (belong) of S1P
20) Confidence 0.31 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.06 Pain Relevance 0.03

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox