INT116164

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Context Info
Confidence 0.66
First Reported 2004
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 5
Total Number 7
Disease Relevance 4.72
Pain Relevance 2.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (S1pr1) plasma membrane (S1pr1) signal transducer activity (S1pr1)
Anatomy Link Frequency
renal proximal tubule 4
plasma 2
myocytes 2
HK-2 2
S1pr1 (Mus musculus)
Pain Link Frequency Relevance Heat
isoflurane 30 99.98 Very High Very High Very High
ischemia 6 92.80 High High
anesthesia 4 91.76 High High
fibrosis 9 89.92 High High
antagonist 20 88.84 High High
agonist 23 87.88 High High
Potency 6 77.56 Quite High
Arthritis 128 66.44 Quite High
Inflammation 87 66.04 Quite High
rheumatoid arthritis 130 62.80 Quite High
Disease Link Frequency Relevance Heat
Hypertension 5 99.80 Very High Very High Very High
Systemic Sclerosis 2 99.68 Very High Very High Very High
Heart Rate Under Development 4 99.46 Very High Very High Very High
Apoptosis 105 95.92 Very High Very High Very High
Injury 15 93.76 High High
Cv Unclassified Under Development 6 92.80 High High
Pulmonary Fibrosis 3 89.92 High High
Renal Failure 3 89.12 High High
Necrosis 13 87.68 High High
Fibrosis 6 86.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We sought to determine whether isoflurane stimulates sphingosine kinase (SK) activity and synthesis of sphingosine-1-phosphate (S1P) in renal proximal tubule cells to mediate renal protection via the S1P signaling pathway.
Spec (whether) Positive_regulation (stimulates) of Gene_expression (synthesis) of sphingosine-1-phosphate in renal proximal tubule associated with isoflurane
1) Confidence 0.66 Published 2007 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 17898040 Disease Relevance 0.66 Pain Relevance 0.57
We sought to determine whether isoflurane stimulates sphingosine kinase (SK) activity and synthesis of sphingosine-1-phosphate (S1P) in renal proximal tubule cells to mediate renal protection via the S1P signaling pathway.
Spec (whether) Positive_regulation (stimulates) of Gene_expression (synthesis) of S1P in renal proximal tubule associated with isoflurane
2) Confidence 0.48 Published 2007 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 17898040 Disease Relevance 0.67 Pain Relevance 0.57
Finally, isoflurane increased the generation of S1P in HK-2 cells.
Positive_regulation (increased) of Gene_expression (generation) of S1P in HK-2 associated with isoflurane
3) Confidence 0.45 Published 2007 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 17898040 Disease Relevance 0.62 Pain Relevance 0.61
Immunolocalization of S1P(3) in rodent heart revealed abundant expression on myocytes and perivascular smooth muscle cells consistent with regulation of bradycardia and hypertension, whereas S1P(1) expression was restricted to the vascular endothelium.
Positive_regulation (restricted) of Gene_expression (expression) of S1P in myocytes associated with heart rate under development and hypertension
4) Confidence 0.44 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14747617 Disease Relevance 1.01 Pain Relevance 0.21
S1P is produced by the activation (i.e., phosphorylation) of sphingosine (Sph) via its 2 isoforms of sphingosine kinase-1/2 (SphK-1/2) resulting in the production of the prosurvival S1P molecule with decreasing levels of the proapoptotic Sph molecule [35].
Positive_regulation (resulting) of Gene_expression (production) of S1P
5) Confidence 0.35 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2842969 Disease Relevance 0.44 Pain Relevance 0.09
S1P is produced by the activation (i.e., phosphorylation) of sphingosine (Sph) via its 2 isoforms of sphingosine kinase-1/2 (SphK-1/2) resulting in the production of the prosurvival S1P molecule with decreasing levels of the proapoptotic Sph molecule [35].
Positive_regulation (via) of Gene_expression (produced) of S1P
6) Confidence 0.27 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2842969 Disease Relevance 0.45 Pain Relevance 0.09
A recent study using plasma and serum samples from systemic scleroderma patients found elevated LPA and S1P levels.
Positive_regulation (elevated) of Gene_expression (levels) of S1P in plasma associated with systemic sclerosis
7) Confidence 0.23 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.87 Pain Relevance 0.27

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