INT116165

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Context Info
Confidence 0.80
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.20
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (S1pr1) plasma membrane (S1pr1) signal transducer activity (S1pr1)
Anatomy Link Frequency
myocytes 1
S1pr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 63 97.08 Very High Very High Very High
agonist 25 95.52 Very High Very High Very High
Potency 6 85.20 High High
Arthritis 64 73.04 Quite High
rheumatoid arthritis 65 49.60 Quite Low
metalloproteinase 5 27.72 Quite Low
anesthesia 2 25.00 Low Low
chemokine 4 23.08 Low Low
cytokine 17 22.60 Low Low
alcohol 2 16.92 Low Low
Disease Link Frequency Relevance Heat
Apoptosis 60 98.64 Very High Very High Very High
Asthma 20 98.24 Very High Very High Very High
Hypertension 5 97.76 Very High Very High Very High
INFLAMMATION 37 97.08 Very High Very High Very High
Hypersensitivity 12 96.28 Very High Very High Very High
Heart Rate Under Development 4 94.88 High High
Toxicity 4 91.56 High High
Lymphopenia 1 87.20 High High
Arthritis 62 73.04 Quite High
Cancer 36 69.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is thus possible that endogenously released S1P is one of the mediators that play significant roles in the initiation and/or progression of allergic bronchial asthma.
Localization (released) of S1P associated with asthma and hypersensitivity
1) Confidence 0.80 Published 2010 Journal The Open Respiratory Medicine Journal Section Body Doc Link PMC3024555 Disease Relevance 0.64 Pain Relevance 0.21
Immunolocalization of S1P(3) in rodent heart revealed abundant expression on myocytes and perivascular smooth muscle cells consistent with regulation of bradycardia and hypertension, whereas S1P(1) expression was restricted to the vascular endothelium.
Localization (Immunolocalization) of S1P in myocytes associated with heart rate under development and hypertension
2) Confidence 0.75 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14747617 Disease Relevance 1.08 Pain Relevance 0.23
Additionally, it was shown that the secreted form of S1P also regulated cell survival and apoptosis by its capacity to bind to and activate 5 specific G protein-coupled receptors, S1P1-S1P15 [35].
Localization (secreted) of S1P associated with apoptosis
3) Confidence 0.46 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2842969 Disease Relevance 0.42 Pain Relevance 0.10
Chronologically, the endothelial gene (EDG) family was the first shown to encode GPCR specific for S1P and LPA.
Localization (specific) of S1P
4) Confidence 0.35 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.07 Pain Relevance 0.03

General Comments

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