INT116181

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Context Info
Confidence 0.79
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 2.17
Pain Relevance 3.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Npy1r) plasma membrane (Npy1r) molecular_function (Npy1r)
signal transducer activity (Npy1r)
Anatomy Link Frequency
dental pulp 2
trigeminal ganglion 1
ARC 1
arcuate nucleus 1
gingiva 1
Npy1r (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 20 99.72 Very High Very High Very High
Neuropeptide 22 99.46 Very High Very High Very High
Antinociceptive 1 97.32 Very High Very High Very High
Codeine 109 96.60 Very High Very High Very High
agonist 6 96.40 Very High Very High Very High
qutenza 8 95.00 High High
antagonist 6 94.16 High High
nociceptor 8 93.84 High High
antinociception 5 92.96 High High
Calcitonin gene-related peptide 1 87.80 High High
Disease Link Frequency Relevance Heat
Aids-related Complex 9 99.52 Very High Very High Very High
Nociception 3 98.56 Very High Very High Very High
INFLAMMATION 18 97.60 Very High Very High Very High
Lordosis 6 91.12 High High
Pulpitis 5 89.68 High High
Injury 1 66.68 Quite High
Pain 3 48.48 Quite Low
Sprains And Strains 1 5.00 Very Low Very Low Very Low
Cough 1 5.00 Very Low Very Low Very Low
Diarrhoea 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Jaws were removed, decalcified and processed for immunohistochemistry for identification and localization of Y1R.
Localization (localization) of Y1R in Jaws
1) Confidence 0.79 Published 2010 Journal Int Endod J Section Body Doc Link 20536577 Disease Relevance 0.09 Pain Relevance 0
AIM: To study the pattern of neuropeptide Y (NPY) Y1 receptor (Y1R) localization in the normal dental pulp and during different stages of pulpal inflammation.
Localization (localization) of Y1R in dental pulp associated with inflammation and neuropeptide
2) Confidence 0.79 Published 2010 Journal Int Endod J Section Abstract Doc Link 20536577 Disease Relevance 0.17 Pain Relevance 0.26
RESULTS: RT-PCR revealed the presence of NPY-Y1R in the dental pulp, trigeminal ganglion and gingiva.
Localization (presence) of NPY-Y1R in trigeminal ganglion
3) Confidence 0.74 Published 2010 Journal Int Endod J Section Body Doc Link 20536577 Disease Relevance 0.08 Pain Relevance 0
NPY reversed the progesterone blockade of estradiol-induced Y1R and MOR internalization in the arcuate nucleus and MPN, respectively.
Localization (internalization) of Y1R in arcuate nucleus
4) Confidence 0.68 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 14749439 Disease Relevance 0.16 Pain Relevance 0.45
Examination of adult rat dorsal root ganglia using double immunofluorescent labeling revealed frequent co-localization of Y1 receptor immunoreactivity in vanilloid receptor type 1-immunoreactive neurons, indicating that Y1 agonists may directly modulate the capsaicin-sensitive class of nociceptors.
Localization (co-localization) of Y1 receptor in dorsal root ganglia associated with qutenza, nociceptor and agonist
5) Confidence 0.64 Published 2004 Journal Neuroscience Section Abstract Doc Link 15099684 Disease Relevance 0.14 Pain Relevance 1.30
Both Y1 receptor and endogenous released NPY in the ARC are involved in the nociceptive modulation during inflammation.
Localization (released) of Y1 receptor in ARC associated with nociception, inflammation and aids-related complex
6) Confidence 0.37 Published 2005 Journal Pain Section Abstract Doc Link 16216414 Disease Relevance 1.21 Pain Relevance 0.77
RESULTS: RT-PCR revealed the presence of NPY-Y1R in the dental pulp, trigeminal ganglion and gingiva.
Localization (presence) of NPY-Y1R in gingiva
7) Confidence 0.25 Published 2010 Journal Int Endod J Section Body Doc Link 20536577 Disease Relevance 0.08 Pain Relevance 0
RESULTS: RT-PCR revealed the presence of NPY-Y1R in the dental pulp, trigeminal ganglion and gingiva.
Localization (presence) of NPY-Y1R in dental pulp
8) Confidence 0.25 Published 2010 Journal Int Endod J Section Body Doc Link 20536577 Disease Relevance 0.08 Pain Relevance 0
NPY reversed the progesterone blockade of estradiol-induced Y1R and MOR internalization in the arcuate nucleus and MPN, respectively.
Localization (internalization) of Y1R in MPN
9) Confidence 0.23 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 14749439 Disease Relevance 0.16 Pain Relevance 0.45
These results indicate that FC5L, referred to as FC5 mini-aptamer, contains the necessary and sufficient sequence within FC5 for binding codeine (Figure 6A and C).
Localization (referred) of FC5 associated with codeine
10) Confidence 0.23 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1636496 Disease Relevance 0 Pain Relevance 0.72

General Comments

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