INT116194

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Context Info
Confidence 0.75
First Reported 2004
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 14.61
Pain Relevance 2.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Casp8) peptidase activity (Casp8) mitochondrion (Casp8)
nucleus (Casp8) protein complex (Casp8) cytoplasm (Casp8)
Anatomy Link Frequency
liver 2
sciatic nerve 1
brain 1
skin 1
heart 1
Casp8 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 11 99.84 Very High Very High Very High
Hyperalgesia 1 98.60 Very High Very High Very High
cva 30 98.34 Very High Very High Very High
allodynia 4 97.92 Very High Very High Very High
withdrawal 4 97.84 Very High Very High Very High
methadone 2 97.54 Very High Very High Very High
Sciatic nerve 3 96.92 Very High Very High Very High
Inflammation 64 94.80 High High
peripheral neuropathy 2 92.36 High High
Neuropathic pain 2 87.24 High High
Disease Link Frequency Relevance Heat
Apoptosis 413 100.00 Very High Very High Very High
Targeted Disruption 156 99.96 Very High Very High Very High
Medulloblastoma 1 99.86 Very High Very High Very High
Carcinoma 26 99.84 Very High Very High Very High
Death 104 99.20 Very High Very High Very High
Pancreatic Cancer 6 99.20 Very High Very High Very High
Urological Neuroanatomy 6 99.16 Very High Very High Very High
Hyperalgesia 1 98.60 Very High Very High Very High
Cognitive Disorder 3 98.44 Very High Very High Very High
Cancer 108 98.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RT-PCR analysis showed increased expression of caspase-1, caspase-12 and caspase-8 genes in the orbito-frontal cortex 14 days after spared nerve injury of the sciatic nerve.
Gene_expression (expression) of caspase-8 in sciatic nerve associated with nervous system injury, urological neuroanatomy and sciatic nerve
1) Confidence 0.75 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19100257 Disease Relevance 1.59 Pain Relevance 0.70
Caspase-3 and caspase-8 activation could not be detected.
Neg (not) Gene_expression (detected) of caspase-8
2) Confidence 0.38 Published 2007 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 17207453 Disease Relevance 0.43 Pain Relevance 0.66
OBJECTIVES: This study analyzes the effects of prolonged administration of methadone and withdrawal on sensorimotor and cognitive performance in mice and explores the associated changes in brain expression of proteins regulating the extrinsic (FasL, Fas, and caspase-8) and the mitochondrial (Bcl-2, Bcl-x(L), Bad, and Bax) apoptotic pathways.
Gene_expression (expression) of caspase-8 in brain associated with cognitive disorder, methadone, apoptosis and withdrawal
3) Confidence 0.29 Published 2007 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 17384938 Disease Relevance 0.35 Pain Relevance 0.26
Neither ethanol nor ADH affected the expression of ANP, total pro-caspase-9, cytosolic and total pro-caspase-8, TNF-?
Gene_expression (expression) of pro-caspase-8
4) Confidence 0.22 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2807457 Disease Relevance 0.66 Pain Relevance 0.07
A rapid activation of splenic apoptosis in HS mice was observed at t = 0 hours and t = 72 hours after hemorrhage and predominantly confirmed by increased DNA fragmentation, elevated caspase-3/7, caspase-8, and caspase-9 activities, and enhanced expression of intrinsic mitochondrial proteins.
Gene_expression (expression) of caspase-8 associated with cva, hemorrhagic shock and apoptosis
5) Confidence 0.22 Published 2008 Journal Crit Care Section Abstract Doc Link PMC2374615 Disease Relevance 2.05 Pain Relevance 0.14
Our transgenic mice resemble to some extent moderately overexpressing caspase-8 transgenic mice [34], whose survival rates do not significantly differ from wild type mice and which developed a dilated heart and decreased systolic function.
Gene_expression (overexpressing) of caspase-8 in heart associated with targeted disruption
6) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2680037 Disease Relevance 0.90 Pain Relevance 0
We validated that the expression of Caspase 8, Fas and Birc5 genes was altered by real time RT-PCR (Figure 5).
Gene_expression (expression) of Caspase 8
7) Confidence 0.20 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2610035 Disease Relevance 0.90 Pain Relevance 0
Our results showed that expression of Caspase 8 is lower in skin from K14E6 as compared to FVB mice.
Gene_expression (expression) of Caspase 8 in skin
8) Confidence 0.20 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2610035 Disease Relevance 1.36 Pain Relevance 0
Caspase-8 and Bid were cleaved in Colo357 cells exposed to gemcitabine, and there was no correlation with either Bcl-xL or with Bax expression.
Gene_expression (cleaved) of Caspase-8
9) Confidence 0.17 Published 2004 Journal Int. J. Cancer Section Abstract Doc Link 14750167 Disease Relevance 1.44 Pain Relevance 0.10
Furthermore, according to the results from Western blot analysis, EEP decreased APAP-induced caspase-3 and caspase-8 protein expressions in mouse livers markedly.
Gene_expression (expressions) of caspase-8 protein in livers
10) Confidence 0.13 Published 2010 Journal J Ethnopharmacol Section Body Doc Link 19833181 Disease Relevance 0.06 Pain Relevance 0
to upregulate caspase-8 in medulloblastoma cells lacking caspase-8, and restore TRAIL-mediated cytotoxicity.
Neg (lacking) Gene_expression (lacking) of caspase-8 associated with medulloblastoma
11) Confidence 0.07 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2842969 Disease Relevance 1.10 Pain Relevance 0.17
The levels of Fas expression and caspase 8 activities are the same in infected and uninfected liver cells of mice, but hydroxyl radicals are increased in infected mice [36].
Gene_expression (expression) of caspase 8 in liver
12) Confidence 0.05 Published 2010 Journal Parasit Vectors Section Body Doc Link PMC2995786 Disease Relevance 1.40 Pain Relevance 0.04
As a first step, we examined activity levels of the extrinsic apoptotic initiator, caspase-8, and intrinsic apoptotic initiator caspase-9 levels in carcinoma cells secreting varying amounts of CXCL12 (Hi, Med, Low) [24].
Gene_expression (levels) of caspase-8 associated with carcinoma and apoptosis
13) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943927 Disease Relevance 1.52 Pain Relevance 0
Recently we showed that the FADD and caspase-8 deficient cells were completely resistant to Fas-induced apoptosis [17].
Gene_expression (resistant) of caspase-8 associated with apoptosis
14) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2671171 Disease Relevance 0.84 Pain Relevance 0

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