INT116195

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Context Info
Confidence 0.15
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 4.33
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Casp9) peptidase activity (Casp9) mitochondrion (Casp9)
nucleus (Casp9) cytoplasm (Casp9)
Anatomy Link Frequency
poly 2
cleavage 1
Casp9 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 3 66.44 Quite High
antagonist 1 62.00 Quite High
palliative 1 53.88 Quite High
ischemia 3 53.84 Quite High
chemokine 21 50.00 Quite Low
alcohol 14 50.00 Quite Low
Bioavailability 2 10.16 Low Low
imagery 7 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 123 98.32 Very High Very High Very High
Cancer 80 97.80 Very High Very High Very High
Stress 7 94.04 High High
Pancreatic Cancer 6 90.44 High High
Severe Combined Immunodeficiency 4 84.36 Quite High
Colon Cancer 25 82.08 Quite High
Death 33 81.80 Quite High
Metastasis 29 77.20 Quite High
Infection 1 75.72 Quite High
Adhesions 35 71.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, the lack of mitochondrial transmembrane potential transition, release of cytochrome-c and absence of caspase-9- and PARP-cleavage showed a strong correlation with Bcl-xL expression.
Localization (release) of caspase-9 in cleavage
1) Confidence 0.15 Published 2004 Journal Int. J. Cancer Section Abstract Doc Link 14750167 Disease Relevance 1.55 Pain Relevance 0.08
It has been demonstrated that pro-caspase-8 and pro-caspase-9 are predominantly localized in mitochondria which are released into cytoplasm upon permeabilization of the outer mitochondrial membrane upon apoptosis stimulation or oxidative stress [42], [43].
Localization (localized) of pro-caspase-9 associated with stress and apoptosis
2) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2807457 Disease Relevance 1.06 Pain Relevance 0.03
Antibodies specific for Bax, Bak, Mcl-1, Bim, phospho-Bad, total Bad, Puma, Bcl-2, Bcl-XL, cleaved poly-ADP ribose polymerase (PARP), cleaved caspase-3, cleaved caspase-9, cleaved caspase-8, and cleaved caspase-7 were from (Cell Signaling, Danvers, MA, USA).
Localization (cleaved) of caspase-9 in poly
3) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943927 Disease Relevance 0.61 Pain Relevance 0
It suppresses the expression of cyclin D1, which is deregulated in several types of tumor, and it also induces apoptosis in tumor cells by activating caspase-8, which leads to cleavage of Bid, thus resulting in sequential release of mitochondrial cytochrome c and activation of caspase-9 and caspase-3, cleavage of poly ADP ribose polymerase (PARP) and apoptosis of tumor cells.
Localization (cleavage) of caspase-9 in poly associated with cancer and apoptosis
4) Confidence 0.04 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2898702 Disease Relevance 1.10 Pain Relevance 0.06

General Comments

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