INT116197

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.67
First Reported 2003
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 7.11
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (CFLAR)
CFLAR (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 72 99.00 Very High Very High Very High
tolerance 9 95.64 Very High Very High Very High
COX-2 inhibitor 4 95.28 Very High Very High Very High
Infliximab 57 90.48 High High
agonist 28 89.68 High High
rheumatoid arthritis 134 88.08 High High
antagonist 29 85.24 High High
withdrawal 3 80.04 Quite High
palliative 2 77.12 Quite High
chemokine 19 56.48 Quite High
Disease Link Frequency Relevance Heat
Inflammatory Bowel Disease 84 99.66 Very High Very High Very High
Lung Cancer 8 99.48 Very High Very High Very High
Disease 130 99.36 Very High Very High Very High
INFLAMMATION 74 99.00 Very High Very High Very High
Apoptosis 183 98.96 Very High Very High Very High
Autoimmune Disease 42 98.96 Very High Very High Very High
Infection 8 98.96 Very High Very High Very High
Cancer 91 94.00 High High
Severe Combined Immunodeficiency 5 93.20 High High
Death 40 92.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Specifically, overexpression of c-FLIP has been shown to induce autoimmunity [71].
Positive_regulation (overexpression) of Gene_expression (overexpression) of c-FLIP associated with autoimmune disease
1) Confidence 0.67 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193735 Disease Relevance 1.01 Pain Relevance 0.26
In addition, cells were transfected with c-FLIP to assess involvement of CD95 and caspase-8.
Positive_regulation (transfected) of Gene_expression (transfected) of c-FLIP
2) Confidence 0.49 Published 2004 Journal Int. J. Cancer Section Abstract Doc Link 14750167 Disease Relevance 1.19 Pain Relevance 0.12
Expression of c-FLIP significantly increased the resistance towards gemcitabine.
Positive_regulation (increased) of Gene_expression (Expression) of c-FLIP
3) Confidence 0.49 Published 2004 Journal Int. J. Cancer Section Abstract Doc Link 14750167 Disease Relevance 1.56 Pain Relevance 0.03
The intrinsic defect in CD occurs in the mitochondrial pathway of apoptosis (imbalance of mitochondrial bcl-2/bax), whereas in UC it results from overexpression of FLICE-inhibitory protein (FLIP) and impairment of the caspase-mediated pathway of apoptosis (Peppelenbosch and van Deventer 2004).
Positive_regulation (overexpression) of Gene_expression (overexpression) of FLIP associated with inflammatory bowel disease, apoptosis and disease
4) Confidence 0.49 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721383 Disease Relevance 1.37 Pain Relevance 0.19
This was accompanied by activated Fas signaling and decreased expression of c-FLIP.
Positive_regulation (activated) of Gene_expression (expression) of c-FLIP
5) Confidence 0.49 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768824 Disease Relevance 1.29 Pain Relevance 0.08
When c-FLIP was
Positive_regulation (When) of Gene_expression (was) of c-FLIP
6) Confidence 0.12 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442903 Disease Relevance 0.70 Pain Relevance 0.23

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox