INT116206

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Context Info
Confidence 0.67
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.52
Pain Relevance 1.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Plat) extracellular space (Plat) extracellular region (Plat)
molecular_function (Plat) cytoplasm (Plat)
Anatomy Link Frequency
blood 1
peripheral nerve 1
Plat (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dorsal horn 5 100.00 Very High Very High Very High
Sciatic nerve 2 97.88 Very High Very High Very High
Thermal hyperalgesia 1 96.60 Very High Very High Very High
Pain 2 96.16 Very High Very High Very High
Peripheral nerve injury 3 95.32 Very High Very High Very High
Dorsal horn neuron 2 93.48 High High
intrathecal 1 88.68 High High
Neuropathic pain 2 87.76 High High
anesthesia 6 76.60 Quite High
long-term potentiation 1 59.16 Quite High
Disease Link Frequency Relevance Heat
Stroke 57 99.64 Very High Very High Very High
Hyperalgesia 1 96.60 Very High Very High Very High
Pain 2 96.16 Very High Very High Very High
Nervous System Injury 3 94.88 High High
Adhesions 23 92.96 High High
Neuropathic Pain 2 87.76 High High
Middle Cerebral Artery Infarction 31 68.16 Quite High
Nociception 1 64.84 Quite High
Cv General 4 Under Development 3 59.76 Quite High
INFLAMMATION 5 56.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings suggest that the increased tPA in the dorsal horn due to mRNA expression in the dorsal root ganglia increases the dorsal horn excitability and has an important role in pain behaviour after peripheral nerve injury.
Transcription (expression) of tPA in peripheral nerve associated with pain, nervous system injury, dorsal horn and peripheral nerve injury
1) Confidence 0.67 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 14750967 Disease Relevance 0.66 Pain Relevance 1.02
We used six groups: the control (I/R) (n = 5) group received an intravenous infusion of saline; the second group (tPA, n = 5) was treated with t-PA (human rtPA, Sigma Chemical, St.
Transcription (human) of tPA
2) Confidence 0.67 Published 2002 Journal BMC Cardiovasc Disord Section Body Doc Link PMC117121 Disease Relevance 0.20 Pain Relevance 0.10
MMP-9 mRNA expression in the blood following tPA treated ischemic stroke remains poorly studied.
Transcription (expression) of tPA in blood associated with stroke
3) Confidence 0.59 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2875237 Disease Relevance 0.66 Pain Relevance 0.06

General Comments

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