INT116216

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Context Info
Confidence 0.43
First Reported 2004
Last Reported 2011
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 3.11
Pain Relevance 2.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Kcna5) plasma membrane (Kcna5) transmembrane transport (Kcna5)
Anatomy Link Frequency
T-lymphocytes 3
neurons 2
macrophages 1
Kcna5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 26 99.98 Very High Very High Very High
diclofenac 14 99.98 Very High Very High Very High
Snapping jaw 16 99.72 Very High Very High Very High
dorsal root ganglion 16 99.56 Very High Very High Very High
Neuropathic pain 11 98.08 Very High Very High Very High
trigeminal ganglion 44 96.24 Very High Very High Very High
rheumatoid arthritis 2 95.24 Very High Very High Very High
Pain 19 93.28 High High
cINOD 2 91.60 High High
allodynia 22 90.80 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 26 99.98 Very High Very High Very High
Temporomandibular Joint Syndrome 16 99.72 Very High Very High Very High
Ganglion Cysts 61 99.56 Very High Very High Very High
Neuropathic Pain 51 98.08 Very High Very High Very High
Rheumatoid Arthritis 2 95.24 Very High Very High Very High
Autoimmune Disease 6 94.08 High High
Nervous System Injury 30 87.12 High High
Nociception 5 79.84 Quite High
Depression 3 58.40 Quite High
Injury 3 50.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that Kv1.1 and Kv1.2 subunits are major components of voltage-gated K+ channels in L4-L5 DRG neurons and that the decreased expression of Kv1-family subunits significantly contributes to the reduction and altered kinetics of Kv current in axotomized neurons.
Negative_regulation (decreased) of Gene_expression (expression) of Kv1 in neurons associated with dorsal root ganglion
1) Confidence 0.43 Published 2004 Journal Neuroscience Section Abstract Doc Link 14751280 Disease Relevance 0.54 Pain Relevance 0.36
While diclofenac inhibited Kv1.3 expression in activated macrophages and T-lymphocytes, Kv1.5 remained unaffected.
Negative_regulation (inhibited) of Gene_expression (expression) of Kv1 in T-lymphocytes associated with diclofenac
2) Confidence 0.43 Published 2010 Journal Biochem. Pharmacol. Section Abstract Doc Link 20488163 Disease Relevance 0.45 Pain Relevance 0.65
Previously, we reported that TMJ inflammation decreased the expression of Kv1.4 subunits in small-/medium-diameter (A?
Negative_regulation (decreased) of Gene_expression (expression) of Kv1 associated with snapping jaw and inflammation
3) Confidence 0.30 Published 2011 Journal Mol Pain Section Body Doc Link PMC3024960 Disease Relevance 1.67 Pain Relevance 0.98
While diclofenac inhibited Kv1.3 expression in activated macrophages and T-lymphocytes, Kv1.5 remained unaffected.
Negative_regulation (inhibited) of in macrophages Gene_expression (expression) of Kv1 in T-lymphocytes associated with diclofenac
4) Confidence 0.15 Published 2010 Journal Biochem. Pharmacol. Section Abstract Doc Link 20488163 Disease Relevance 0.45 Pain Relevance 0.65

General Comments

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