INT116220

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Context Info
Confidence 0.78
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.86
Pain Relevance 3.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HTR1B) cytoplasm (HTR1B) signal transducer activity (HTR1B)
Anatomy Link Frequency
nerve 2
trigeminal ganglion 1
neuronal 1
HTR1B (Homo sapiens)
Pain Link Frequency Relevance Heat
Neurotransmitter 4 99.98 Very High Very High Very High
fluoxetine 7 99.82 Very High Very High Very High
Calcitonin gene-related peptide 66 99.76 Very High Very High Very High
Central nervous system 7 99.44 Very High Very High Very High
trigeminal ganglion 13 99.04 Very High Very High Very High
Analgesic 3 98.84 Very High Very High Very High
unmyelinated 1 96.96 Very High Very High Very High
ergotamine 2 96.48 Very High Very High Very High
sSRI 5 95.56 Very High Very High Very High
headache 23 90.72 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 14 98.60 Very High Very High Very High
Increased Venous Pressure Under Development 11 97.88 Very High Very High Very High
Headache 61 90.72 High High
Nociception 3 83.52 Quite High
Urological Neuroanatomy 2 65.52 Quite High
Cluster Headache 2 62.52 Quite High
Drug Dependence 1 25.00 Low Low
Disease 1 25.00 Low Low
Pain 23 5.00 Very Low Very Low Very Low
Neuropathic Pain 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The terminal localization of the 5-HT1B receptors in CNS suggests that there is a signal responsible for the protein transport toward the nerve terminals.
Localization (localization) of 5-HT1B in nerve associated with central nervous system
1) Confidence 0.78 Published 2004 Journal Neurosci Biobehav Rev Section Abstract Doc Link 15527863 Disease Relevance 0 Pain Relevance 0.38
Chronic fluoxetine-induced desensitization of 5-HT1A and 5-HT1B autoreceptors: regional differences and effects of WAY-100635.
Localization (desensitization) of 5-HT1B associated with fluoxetine
2) Confidence 0.73 Published 2004 Journal Eur. J. Pharmacol. Section Title Doc Link 14751404 Disease Relevance 0.07 Pain Relevance 0.56
We also suggest that 5HT1B/1D receptors are mainly localized in the BA and MCA, and that analgesic overuse results in a functional disorder of neuronal receptor and neurovascular reflexes and may cause a reduction of intracerebral vessel tone, leading to vasodilatation.
Localization (localized) of 5HT1B in neuronal associated with analgesic and increased venous pressure under development
3) Confidence 0.73 Published 2008 Journal Funct. Neurol. Section Abstract Doc Link 18671908 Disease Relevance 0.87 Pain Relevance 0.93
Furthermore, the 5-HT1B/1D receptors were co-localized with CGRP in the human trigeminal ganglion [20].
Localization (localized) of 5-HT1B in trigeminal ganglion associated with ganglion cysts, trigeminal ganglion and calcitonin gene-related peptide
4) Confidence 0.73 Published 2008 Journal J Headache Pain Section Body Doc Link PMC2245994 Disease Relevance 0.92 Pain Relevance 1.33
The effects of T3, alone and together with the SSRI fluoxetine, on mRNA levels for the 5-HT1A and 5-HT1B autoreceptors, which mediate serotonergic neurotransmission by feedback actions at the levels of cell firing(somatodendritic 5-HT1A autoreceptors) and neurotransmitter release (nerve terminal 5-HT1B autoreceptors) were also determined.
Localization (release) of 5-HT1B in nerve associated with neurotransmitter, ssri and fluoxetine
5) Confidence 0.68 Published 2006 Journal Curr Drug Targets Section Abstract Doc Link 16475961 Disease Relevance 0 Pain Relevance 0.55

General Comments

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