INT116229

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Context Info
Confidence 0.77
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 28
Total Number 29
Disease Relevance 18.53
Pain Relevance 5.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
spinal cord 2
brain 2
plaque 2
synapse 2
neuronal 1
C1qa (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 118 100.00 Very High Very High Very High
Inflammation 819 99.70 Very High Very High Very High
Spinal cord 407 99.10 Very High Very High Very High
Glutamate 3 98.94 Very High Very High Very High
Hippocampus 179 98.80 Very High Very High Very High
chemokine 55 97.92 Very High Very High Very High
Eae 5 95.92 Very High Very High Very High
Abeta 2 95.84 Very High Very High Very High
Neuropathic pain 9 91.64 High High
Sciatic nerve 1 91.64 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 82 99.76 Very High Very High Very High
INFLAMMATION 886 99.70 Very High Very High Very High
Apoptosis 17 99.32 Very High Very High Very High
Disease 683 98.98 Very High Very High Very High
Death 93 98.94 Very High Very High Very High
Injury 481 98.68 Very High Very High Very High
Spinal Cord Injury 490 98.60 Very High Very High Very High
Brain Injury 13 98.56 Very High Very High Very High
Gliosis 9 97.88 Very High Very High Very High
Urological Neuroanatomy 12 96.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the preclinical subject, C1q was abundantly present but it was cell-associated only, being primarily colocalized with neurons in both frontal cortex and hippocampus.
Gene_expression (present) of C1q in frontal cortex associated with urological neuroanatomy and hippocampus
1) Confidence 0.77 Published 2004 Journal Neurobiol. Dis. Section Abstract Doc Link 14751769 Disease Relevance 1.02 Pain Relevance 0.29
Expression of C1q, C3, C4, C5, C6, C7, C9, CD59, Crry, and GADPH mRNAs in cultured PMNs was assayed by rt-PCR.
Gene_expression (Expression) of C1q
2) Confidence 0.75 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2443364 Disease Relevance 0 Pain Relevance 0
As shown in Figure 3 by rt-PCR, both unstimulated PMNs and stimulated PMNs expressed mRNAs encoding for C1q, C3, and C4, but not C6, C7, and C9 in culture.
Gene_expression (expressed) of C1q
3) Confidence 0.75 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2443364 Disease Relevance 0.05 Pain Relevance 0.19
In addition, there was increased expression of the Suppression of Cytokine Signaling (SOCS), CD36, and PD-1L genes and others including C1q.
Gene_expression (expression) of C1q associated with cytokine
4) Confidence 0.75 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2588578 Disease Relevance 0.47 Pain Relevance 0.13
Microarrays provide insight into the molecular pathogenesis of the processes in the outbred mice reflecting inflammation, attenuation of this inflammation by counter regulatory processes, neuronal cell death and potential remodeling of synapses with increased expression of C1q, as well as CD36, immunoglobin genes, GFAP, and PD-1L in these transcriptomes.
Gene_expression (expression) of C1q in neuronal associated with inflammation and death
5) Confidence 0.75 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2588578 Disease Relevance 1.12 Pain Relevance 0.28
The increased expression of C1q raises questions about neuronal synapse remodeling or bystander cell death.
Gene_expression (expression) of C1q in synapse associated with death
6) Confidence 0.75 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2588578 Disease Relevance 0.95 Pain Relevance 0.09
Signaling from immature astrocytes appears to induce C1q expression in microglia and neurons and it was hypothesized that reactive astrocytes seen in brain injury may provide a similar signal, ultimately leading to synapse loss and neuronal death.
Gene_expression (expression) of C1q in synapse associated with death and brain injury
7) Confidence 0.75 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2588578 Disease Relevance 0.73 Pain Relevance 0.03
Our data confirm C3 expression by PMNs in culture, and demonstrate the expression of C1q and C4 by PMNs, providing a more complete characterization of PMN expression of the early complement proteins in culture.
Gene_expression (expression) of C1q
8) Confidence 0.75 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2443364 Disease Relevance 0.42 Pain Relevance 0.18
Many of the commonly regulated transcripts are immune related and include the complement components C1q, C3, and C4, which we find are expressed only by microglia.
Gene_expression (expressed) of C1q in microglia
9) Confidence 0.75 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17687047 Disease Relevance 0.83 Pain Relevance 0.78
These results were interpreted to suggest that in these animal models of AD, (1) early complement activation (as indicated by C1q deposition) in response to fibrillar A?
Gene_expression (deposition) of C1q associated with disease
10) Confidence 0.65 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC529311 Disease Relevance 0.35 Pain Relevance 0.10
Plaque density was decreased by C1q infusion (note: this result differs from the in vitro study of Webster et al. [57], in which C1q was found to inhibit microglial phagocytosis of A?
Gene_expression (infusion) of C1q in Plaque
11) Confidence 0.65 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC529311 Disease Relevance 0.55 Pain Relevance 0.10
APP (Tg2576)/C1q-deficient mouse
Gene_expression (/) of C1q
12) Confidence 0.65 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC529311 Disease Relevance 0.54 Pain Relevance 0.04
, and also from the recent study of Fonseca et al. [99] in which C1q deficiency had no effect on plaque density in APP mice), but, curiously, performance in the water maze worsened.
Gene_expression (deficiency) of C1q in plaque
13) Confidence 0.65 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC529311 Disease Relevance 0.67 Pain Relevance 0.04
The RT-PCR results indicated an increase in C1q mRNA that was more pronounced than the increased expression of GFAP mRNA ipsilateral to the injury in the dorsal spinal cord.
Gene_expression (expression) of C1q in spinal cord associated with injury and spinal cord
14) Confidence 0.65 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19766105 Disease Relevance 0.63 Pain Relevance 0.70
Additionally, of all the PMNs that infiltrating the spinal cord epicenter region, most (over 70%) were also positive for C1q or C3 (Figure 8C &8D).
Gene_expression (positive) of C1q in spinal cord associated with spinal cord
15) Confidence 0.65 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2443364 Disease Relevance 0.50 Pain Relevance 0.26
, C1q and C3 values were obtained by division with the corresponding 18S value and expressed in arbitrary units.


Gene_expression (expressed) of C1q
16) Confidence 0.64 Published 2010 Journal European Journal of Immunology Section Body Doc Link PMC2988415 Disease Relevance 0.07 Pain Relevance 0
C1q is the first component of the classical complement pathway and is best known for its binding to immune complexes and activation of the classical pathway 10,11.
Gene_expression (known) of C1q
17) Confidence 0.64 Published 2010 Journal European Journal of Immunology Section Body Doc Link PMC2988415 Disease Relevance 0.81 Pain Relevance 0.10
We have shown that cultured PMNs expressed mRNAs encoding for the early proteins C1q, C3, and C4, but not the terminal proteins C5, C6, C7, and C9 in vitro.
Gene_expression (expressed) of C1q
18) Confidence 0.58 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2443364 Disease Relevance 0.59 Pain Relevance 0.12
Complement protein C1q or C3 was also detected in less than 30% of cultured PMNs.
Gene_expression (detected) of C1q
19) Confidence 0.58 Published 2008 Journal J Neuroinflammation Section Abstract Doc Link PMC2443364 Disease Relevance 1.24 Pain Relevance 0.37
Stimulated or unstimulated PMNs expressed mRNAs encoding for C1q, C3, and C4, but not C5, C6, C7 or C9 in culture.
Gene_expression (expressed) of C1q in PMNs
20) Confidence 0.58 Published 2008 Journal J Neuroinflammation Section Abstract Doc Link PMC2443364 Disease Relevance 1.32 Pain Relevance 0.34

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