INT116235

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Context Info
Confidence 0.58
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 23
Total Number 23
Disease Relevance 7.91
Pain Relevance 3.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nos2) signal transduction (Nos2) extracellular space (Nos2)
oxidoreductase activity (Nos2) peroxisome (Nos2) nucleus (Nos2)
Anatomy Link Frequency
neuronal 4
arterioles 3
macrophages 2
spinal cord 2
endothelial cells 1
Nos2 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 82 99.24 Very High Very High Very High
cytokine 70 99.16 Very High Very High Very High
Sciatic nerve 77 97.64 Very High Very High Very High
Inflammation 126 96.68 Very High Very High Very High
Neuronal nitric oxide synthase 3 94.04 High High
Neuropathic pain 22 88.28 High High
cINOD 3 87.20 High High
Inflammatory mediators 16 83.64 Quite High
Analgesic 11 79.04 Quite High
Potency 2 78.72 Quite High
Disease Link Frequency Relevance Heat
Sepsis 131 97.04 Very High Very High Very High
INFLAMMATION 164 96.68 Very High Very High Very High
Proteinuria 14 95.88 Very High Very High Very High
Targeted Disruption 105 95.44 Very High Very High Very High
Necrosis 7 95.32 Very High Very High Very High
Cancer 13 94.96 High High
Stress 51 91.96 High High
Renal Disease 82 91.32 High High
Neuropathic Pain 66 88.28 High High
Apoptosis 41 84.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggested that DHCD inhibited NO generation by blocking NF-kappaB activation and iNOS gene transcription.
Negative_regulation (blocking) of Transcription (transcription) of iNOS
1) Confidence 0.58 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14752064 Disease Relevance 0.08 Pain Relevance 0.17
DHCD decreased the levels of protein and mRNA for inducible NO synthase (iNOS).
Negative_regulation (decreased) of Transcription (levels) of iNOS
2) Confidence 0.58 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14752064 Disease Relevance 0.09 Pain Relevance 0.15
The structurally unrelated ER stressor, thapsigargin, also reduced iNOS activity, protein levels, and mRNA transcripts (data not shown).
Negative_regulation (reduced) of Transcription (transcripts) of iNOS
3) Confidence 0.55 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2803434 Disease Relevance 0.15 Pain Relevance 0
Our results revealed that the mRNA expression of inducible nitric oxide synthase (iNOS) was reduced by approximately 50% in GEB-pretreated mice versus the controls, whereas the mRNA expression levels of endothelial nitric oxide synthase (eNOS) and neuronal nitric oxide synthase (nNOS) remained unchanged.
Negative_regulation (reduced) of Transcription (expression) of inducible nitric oxide synthase in neuronal associated with neuronal nitric oxide synthase
4) Confidence 0.50 Published 2007 Journal Int. J. Mol. Med. Section Abstract Doc Link 17611639 Disease Relevance 0.50 Pain Relevance 0.14
These mice were shown to lack detectable iNOS mRNA and iNOS protein, and not to produce NO (as detected by serum nitrate/nitrite levels) after endotoxin stimulation [11].


Negative_regulation (lack) of Neg (lack) Transcription (detectable) of iNOS
5) Confidence 0.43 Published 2007 Journal Crit Care Section Body Doc Link PMC2246221 Disease Relevance 0.33 Pain Relevance 0.04
C. racemosa extracts also reduced iNOS protein expression and iNOS mRNA levels in a dose-dependent manner.
Negative_regulation (reduced) of Transcription (levels) of iNOS
6) Confidence 0.43 Published 2009 Journal J. Pharm. Pharmacol. Section Body Doc Link 19703353 Disease Relevance 0 Pain Relevance 0
DHCD decreased the levels of protein and mRNA for inducible NO synthase (iNOS).
Negative_regulation (decreased) of Transcription (levels) of inducible NO synthase
7) Confidence 0.42 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14752064 Disease Relevance 0.09 Pain Relevance 0.15
These findings collectively suggest that GEB significantly protects the gastric mucosa against WIR-induced gastric damage, at least in part by decreasing NO levels via suppression of iNOS mRNA expression.
Negative_regulation (suppression) of Transcription (expression) of iNOS
8) Confidence 0.42 Published 2007 Journal Int. J. Mol. Med. Section Abstract Doc Link 17611639 Disease Relevance 0.29 Pain Relevance 0.05
Our results revealed that the mRNA expression of inducible nitric oxide synthase (iNOS) was reduced by approximately 50% in GEB-pretreated mice versus the controls, whereas the mRNA expression levels of endothelial nitric oxide synthase (eNOS) and neuronal nitric oxide synthase (nNOS) remained unchanged.
Negative_regulation (reduced) of Transcription (expression) of iNOS in neuronal associated with neuronal nitric oxide synthase
9) Confidence 0.41 Published 2007 Journal Int. J. Mol. Med. Section Abstract Doc Link 17611639 Disease Relevance 0.50 Pain Relevance 0.14
Here we describe the identification of a small molecule that downregulates the expression of iNOS mRNA and protein in cytokine-activated cells and suppresses nitric oxide production in vivo.
Negative_regulation (downregulates) of Transcription (expression) of iNOS associated with cytokine
10) Confidence 0.41 Published 2008 Journal Current Chemical Genomics Section Abstract Doc Link PMC2803434 Disease Relevance 0.08 Pain Relevance 0.05
The concentrations of erstressin required to activate UPR signaling and UPR gene expression are the same as those that reduce iNOS mRNA and protein expression and enzyme activity.
Negative_regulation (reduce) of Transcription (expression) of iNOS
11) Confidence 0.40 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2803434 Disease Relevance 0.13 Pain Relevance 0
Therefore, our subsequent aim is to evaluate the mRNA and protein expression of NOS1 and NOS2 isoenzymes in the spinal cord of WT mice at 21 days after sciatic nerve ligation and correlate it with their corresponding behavior responses.
Negative_regulation (evaluate) of Transcription (expression) of NOS2 in spinal cord associated with sciatic nerve and spinal cord
12) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001461 Disease Relevance 1.15 Pain Relevance 0.94
Consistent with these observations, MEIO potently inhibited the protein and mRNA expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2).
Negative_regulation (inhibited) of Transcription (xpressions ) of inducible nitric oxide synthase
13) Confidence 0.38 Published 2005 Journal J Ethnopharmacol Section Abstract Doc Link 15905055 Disease Relevance 0.99 Pain Relevance 0.23
Consistent with these observations, MEIO potently inhibited the protein and mRNA expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2).
Negative_regulation (inhibited) of Transcription (xpressions ) of iNOS
14) Confidence 0.38 Published 2005 Journal J Ethnopharmacol Section Abstract Doc Link 15905055 Disease Relevance 0.99 Pain Relevance 0.23
CONCLUSION: These results show that amygdalin exerts anti-inflammatory and analgesic effects and it dose so probably by suppressing the mRNA expressions of COX-2 and iNOS.


Negative_regulation (suppressing) of Transcription (expressions) of iNOS
15) Confidence 0.36 Published 2007 Journal Neurol. Res. Section Body Doc Link 17359643 Disease Relevance 0.06 Pain Relevance 0
RESULTS: The present results showed that amygdalin suppressed the prostaglandin E(2) synthesis and the nitric oxide production by inhibiting the LPS-stimulated mRNA expressions of COX-2 and iNOS in the mouse BV2 cells.
Negative_regulation (inhibiting) of Transcription (expressions) of iNOS
16) Confidence 0.36 Published 2007 Journal Neurol. Res. Section Body Doc Link 17359643 Disease Relevance 0.07 Pain Relevance 0
For only one gene was there observed to be a significantly decreased mRNA level at any time point (iNOS), and this was observed only at 8 hours post formalin injection.
Negative_regulation (decreased) of Transcription (level) of iNOS
17) Confidence 0.24 Published 2005 Journal Mol Pain Section Body Doc Link PMC1310513 Disease Relevance 0.05 Pain Relevance 0.21
PZ-mediated inhibition of LPS-induced NO production likely resulted from the inhibition of iNOS mRNA transcription.
Negative_regulation (inhibition) of Transcription (transcription) of iNOS
18) Confidence 0.19 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2872229 Disease Relevance 0.22 Pain Relevance 0.20
Renal cortical levels of iNOS mRNA and urinary nitrate production were reduced in one study (Yu et al 2001) whereas the other study did not find any difference in intrarenal nitric oxide production, iNOS protein and mRNA levels and urinary nitrite/nitrate production at 12 weeks although there was a transient decrease in urinary nitrite/nitrate production at 8 weeks (Lui et al 2002).
Negative_regulation (reduced) of Transcription (levels) of iNOS
19) Confidence 0.13 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721349 Disease Relevance 0.62 Pain Relevance 0.04
Injection i.v. of vitamin C also diminishes iNOS mRNA expression in microvascular endothelial cells and arterioles in an in vivo model of sepsis [32, 33].
Negative_regulation (diminishes) of Transcription (expression) of iNOS in arterioles associated with sepsis
20) Confidence 0.12 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2386519 Disease Relevance 0.16 Pain Relevance 0.06

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