INT11626

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.45
First Reported 1992
Last Reported 2011
Negated 1
Speculated 3
Reported most in Abstract
Documents 4
Total Number 8
Disease Relevance 1.51
Pain Relevance 2.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (App) Golgi apparatus (App) plasma membrane (App)
extracellular matrix organization (App) DNA binding (App) cytoplasm (App)
Anatomy Link Frequency
neurons 2
App (Mus musculus)
Pain Link Frequency Relevance Heat
Abeta 22 100.00 Very High Very High Very High
Kinase C 18 98.80 Very High Very High Very High
Endogenous opioid 1 97.24 Very High Very High Very High
sodium channel 7 96.76 Very High Very High Very High
cINOD 9 90.60 High High
tetrodotoxin 6 85.92 High High
Neuronal excitability 3 83.64 Quite High
alcohol 2 75.00 Quite High
long-term potentiation 3 68.96 Quite High
Inflammation 3 53.40 Quite High
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 29 94.84 High High
Adhesions 14 88.68 High High
Targeted Disruption 38 85.08 High High
Neuroblastoma 3 77.16 Quite High
Death 9 75.68 Quite High
Disease 177 71.88 Quite High
Sprains And Strains 5 70.64 Quite High
INFLAMMATION 5 54.04 Quite High
Drug Induced Neurotoxicity 9 43.92 Quite Low
Endometriosis (extended) 3 36.68 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The available evidence has shown that intracellular trafficking of APP is regulated by a number of factors.
Regulation (regulated) of Localization (trafficking) of APP
1) Confidence 0.45 Published 2011 Journal Mol Brain Section Body Doc Link PMC3022812 Disease Relevance 0.14 Pain Relevance 0.07
As with the case of APP and Notch1, ?
Regulation (with) of Localization (case) of APP
2) Confidence 0.41 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0.33 Pain Relevance 0.05
While PKC can directly phosphorylate APP Ser655 [205], it appears to affect APP metabolism by phosphorylating a different target.
Spec (appears) Regulation (affect) of Localization (metabolism) of APP associated with kinase c
3) Confidence 0.39 Published 2011 Journal Mol Brain Section Body Doc Link PMC3022812 Disease Relevance 0.19 Pain Relevance 0.28
The objective of the present studies was to investigate the effects of various concentrations of ethanol on the release of beta-endorphin (beta-EP) by the hypothalami of mice showing either high (C57BL/6) or low (DBA/2) voluntary ethanol consumption.
Spec (investigate) Regulation (effects) of Localization (release) of beta-EP
4) Confidence 0.28 Published 1992 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1578384 Disease Relevance 0.07 Pain Relevance 0.17
Alterations in APP intracellular trafficking and localization directly impact A?
Regulation (Alterations) of Localization (localization) of APP
5) Confidence 0.24 Published 2011 Journal Mol Brain Section Body Doc Link PMC3022812 Disease Relevance 0.16 Pain Relevance 0.08
The mechanism of catB-mediated regulation of Abeta release remains unclear but may involve elevation of beta-secretase.
Regulation (regulation) of Localization (release) of Abeta associated with abeta
6) Confidence 0.11 Published 2009 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 19064719 Disease Relevance 0.22 Pain Relevance 0.56
In the present study, this concept was extended to investigations in primary hippocampal neurons to test whether Abeta release was coregulated by cathepsins and electrical activity, proposed components of a regulated secretory pathway.
Spec (whether) Regulation (coregulated) of Spec (whether) Localization (release) of Abeta in neurons associated with abeta
7) Confidence 0.11 Published 2009 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 19064719 Disease Relevance 0.17 Pain Relevance 0.37
Targeting ROCK by expression of dominant-negative or constitutively active ROCK mutants failed to modulate Abeta secretion, indicating that ROCK inhibition may either be redundant or insufficient for Abeta reduction by ROCK inhibitors.
Neg (failed) Regulation (modulate) of Localization (secretion) of Abeta associated with abeta
8) Confidence 0.03 Published 2006 Journal J. Neurochem. Section Abstract Doc Link 16300630 Disease Relevance 0.22 Pain Relevance 0.75

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox