INT116265

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Context Info
Confidence 0.36
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 4.28
Pain Relevance 1.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Myc) DNA binding (Myc) protein complex (Myc)
cytoplasm (Myc) pigmentation (Myc) chromosome organization (Myc)
Anatomy Link Frequency
spinal cord 2
spinal 1
hepatocyte 1
nerve 1
A549 1
Myc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 1 100.00 Very High Very High Very High
Inflammation 123 99.84 Very High Very High Very High
Pain 9 99.84 Very High Very High Very High
Spinal cord 68 97.76 Very High Very High Very High
Dorsal horn 1 90.92 High High
Inflammatory stimuli 3 90.32 High High
cytokine 35 80.72 Quite High
Central nervous system 8 73.44 Quite High
imagery 2 70.40 Quite High
intrathecal 1 61.44 Quite High
Disease Link Frequency Relevance Heat
Cancer 285 99.98 Very High Very High Very High
INFLAMMATION 128 99.76 Very High Very High Very High
Injury 137 99.12 Very High Very High Very High
Nociception 7 98.84 Very High Very High Very High
Benign Prostatic Hypertrophy 8 98.08 Very High Very High Very High
Stomach Cancer 1 90.96 High High
Apoptosis 34 90.24 High High
Hypertrophy 1 89.52 High High
Death 15 89.04 High High
Pancreatitis 4 87.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
was also highly expressed in the 13 cases that were positive for the c-Myc but negative in the 2 cases that failed to show c-Myc staining.
c-Myc Binding (negative) of
1) Confidence 0.36 Published 2006 Journal J Carcinog Section Body Doc Link PMC1559682 Disease Relevance 0.80 Pain Relevance 0
Moreover, following obstruction of the bladders of animal models and patients with BPH, there were acute increases in the expression of bFGF (7), the transcription factors, upstream binding factor, c-Jun, and cyclins E and C (8), nerve growth factor (9), N-ras and c-myc (10), and decreased expression of TGF-beta 1 (7).
c-myc Binding (binding) of in nerve associated with benign prostatic hypertrophy and nerve growth factor
2) Confidence 0.36 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2779299 Disease Relevance 0.67 Pain Relevance 0.09
Therefore, lapatinib inhibition of cyclin A may subsequently abrogate c-Myc and, in turn, induce G1 phase arrest in A549 cells.
c-Myc Binding (abrogate) of in A549
3) Confidence 0.36 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2883966 Disease Relevance 0.65 Pain Relevance 0
AUF1 binds to and destabilizes both inflammation and cancer-associated ARE-mRNAs such as c-myc, TNF-?
c-myc Binding (associated) of associated with inflammation and cancer
4) Confidence 0.36 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 1.00 Pain Relevance 0.25
Overall, there were no significant variations in the early induction of several key transcription factors involved in the initiation of hepatocyte proliferation including c-Jun, c-Fos and c-Myc between Metwt/wt;Alb-Cre+/?
c-Myc Binding (initiation) of in hepatocyte
5) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2940888 Disease Relevance 0 Pain Relevance 0.04
MYC, a member of the myc-family of transcription factors, is a complex regulator of general transcriptional activation [50] and has been associated with immediate early injury response of neurons in the spinal cord [51].
MYC Binding (associated) of in spinal cord associated with injury and spinal cord
6) Confidence 0.33 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2900267 Disease Relevance 0.36 Pain Relevance 0.13
MYC, a member of the myc-family of transcription factors, is a complex regulator of general transcriptional activation [50] and has been associated with immediate early injury response of neurons in the spinal cord [51].
myc Binding (associated) of in spinal cord associated with injury and spinal cord
7) Confidence 0.33 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2900267 Disease Relevance 0.36 Pain Relevance 0.11
Protein associated with Myc (PAM) is a giant E3 ubiquitin ligase of 510 kDa.
Myc Binding (associated) of
8) Confidence 0.19 Published 2008 Journal Mol. Cell Proteomics Section Abstract Doc Link 18753128 Disease Relevance 0.07 Pain Relevance 0.04
Protein associated with Myc (PAM) is involved in spinal nociceptive processing.
Myc Binding (associated) of in spinal associated with nociception and inflammation
9) Confidence 0.16 Published 2004 Journal J. Neurochem. Section Title Doc Link 14756816 Disease Relevance 0.36 Pain Relevance 0.71

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