INT11627

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Context Info
Confidence 0.62
First Reported 1992
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 14
Total Number 17
Disease Relevance 6.27
Pain Relevance 3.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (App) Golgi apparatus (App) plasma membrane (App)
extracellular matrix organization (App) DNA binding (App) cytoplasm (App)
Anatomy Link Frequency
plasma 4
neurons 4
primary neurons 2
vesicles 2
synapses 2
App (Mus musculus)
Pain Link Frequency Relevance Heat
Abeta 32 100.00 Very High Very High Very High
cINOD 22 98.56 Very High Very High Very High
tetrodotoxin 9 97.20 Very High Very High Very High
imagery 58 88.40 High High
positron emission tomography 16 85.12 High High
opiate 2 78.40 Quite High
Endogenous opioid 2 76.48 Quite High
alcohol 5 75.00 Quite High
antagonist 5 66.00 Quite High
metalloproteinase 6 63.88 Quite High
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 84 99.86 Very High Very High Very High
Sprains And Strains 12 98.82 Very High Very High Very High
INFLAMMATION 32 98.36 Very High Very High Very High
Targeted Disruption 88 97.76 Very High Very High Very High
Disease 586 96.88 Very High Very High Very High
Amyloid Plaque 47 90.04 High High
Neuroblastoma 29 89.80 High High
Apoptosis 190 88.60 High High
Parkinson's Disease 11 86.24 High High
Drug Induced Neurotoxicity 15 82.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, we find that a nuclear receptor, retinoid X receptor alpha (RXRalpha), can regulate Abeta generation and that down-regulation of RXRalpha significantly increases Abeta secretion.
Positive_regulation (increases) of Localization (secretion) of Abeta associated with abeta
1) Confidence 0.62 Published 2009 Journal J. Neurochem. Section Abstract Doc Link 19659691 Disease Relevance 0.68 Pain Relevance 1.01
Co-expression of ADAM9 with APP promoted sAPP?
Positive_regulation (promoted) of Localization (sAPP) of APP
2) Confidence 0.50 Published 2011 Journal Mol Brain Section Body Doc Link PMC3022812 Disease Relevance 0.14 Pain Relevance 0.06
by promoting APP transport to synapses and secretion of A?
Positive_regulation (promoting) of Localization (transport) of APP in synapses
3) Confidence 0.48 Published 2009 Journal Mol Neurodegener Section Body Doc Link PMC2806870 Disease Relevance 0.14 Pain Relevance 0
Expression of a loss of function PS1 variant, or the absence of PS1, results in increased budding/generation of vesicles from both the ER and TGN containing APP along with a concomitant increase in complex glycosylation and APP localization at the cell surface.
Positive_regulation (increase) of Localization (localization) of APP in vesicles
4) Confidence 0.46 Published 2011 Journal Mol Brain Section Body Doc Link PMC3022812 Disease Relevance 0 Pain Relevance 0
In vitro studies show that transcription from neprilysin gene promoter can be activated by cytosolic domains released from APP, APLP1 or APLP2 by ?
Positive_regulation (activated) of Localization (released) of APP
5) Confidence 0.46 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0.81 Pain Relevance 0.06
secretion and accumulation of APP C-terminal fragments (CTF) in PS1-/- neurons.
Positive_regulation (accumulation) of Localization (secretion) of APP in neurons
6) Confidence 0.46 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0.09 Pain Relevance 0
Further elucidation of APP metabolism will be important for identifying new potential therapies to reduce A?
Positive_regulation (important) of Localization (elucidation) of APP
7) Confidence 0.44 Published 2011 Journal Mol Brain Section Body Doc Link PMC3022812 Disease Relevance 0.33 Pain Relevance 0
GBq/mole; injection of the tracer immediately after synthesis), Maeda and collaborators were nevertheless able to show increased retention of the ligand in APP transgenics.
Positive_regulation (increased) of Localization (retention) of APP
8) Confidence 0.43 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2952791 Disease Relevance 0.88 Pain Relevance 0.19
accumulation may be due to increased overall metabolism of APP, indicative of stimulation of APP trafficking to the plasma membrane.
Positive_regulation (stimulation) of Localization (metabolism) of APP in plasma
9) Confidence 0.42 Published 2009 Journal Mol Neurodegener Section Body Doc Link PMC2806870 Disease Relevance 0.19 Pain Relevance 0
accumulation may be due to increased overall metabolism of APP, indicative of stimulation of APP trafficking to the plasma membrane.
Positive_regulation (increased) of Localization (metabolism) of APP in plasma
10) Confidence 0.42 Published 2009 Journal Mol Neurodegener Section Body Doc Link PMC2806870 Disease Relevance 0.15 Pain Relevance 0
-secretase pathway, thereby increasing the release of the soluble form of APP (sAPP?)
Positive_regulation (increasing) of Localization (release) of APP
11) Confidence 0.29 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2820992 Disease Relevance 0.70 Pain Relevance 0.03
After exposure to various concentrations of ethanol, it was observed that for both strains of mice, low concentrations of ethanol (10, 20 and 25 mM) induced a more pronounced increase in the release of hypothalamic beta-EP than high concentrations of ethanol (30 and 60 mM) leading to an inverse U-shaped dose-response curve.
Positive_regulation (increase) of Localization (release) of beta-EP associated with sprains and strains
12) Confidence 0.25 Published 1992 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1578384 Disease Relevance 0.32 Pain Relevance 0.23
After exposure to various concentrations of ethanol, it was observed that for both strains of mice, low concentrations of ethanol (10, 20 and 25 mM) induced a more pronounced increase in the release of hypothalamic beta-EP than high concentrations of ethanol (30 and 60 mM) leading to an inverse U-shaped dose-response curve.
Positive_regulation (induced) of Localization (release) of beta-EP associated with sprains and strains
13) Confidence 0.25 Published 1992 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1578384 Disease Relevance 0.32 Pain Relevance 0.23
-secretase and production of a soluble secreted form of APP (sAPP?)
Positive_regulation (-) of Localization (secreted) of APP
14) Confidence 0.23 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0.87 Pain Relevance 0.08
In summary, these studies provide evidence for a significant alternative pathway for APP processing that involves catB and activity-dependent release of Abeta in a regulated secretory pathway for primary neurons.
Positive_regulation (involves) of Localization (catB) of Abeta in primary neurons associated with abeta
15) Confidence 0.12 Published 2009 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 19064719 Disease Relevance 0.16 Pain Relevance 0.50
To test whether the catB-dependent release of Abeta was linked to ongoing electrical activity, neurons were treated with tetrodotoxin (TTX) and CA074Me.
Spec (whether) Positive_regulation (dependent) of Localization (release) of Abeta in neurons associated with tetrodotoxin and abeta
16) Confidence 0.12 Published 2009 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 19064719 Disease Relevance 0.22 Pain Relevance 0.56
Inhibitors of Rho-kinase modulate amyloid-beta (Abeta) secretion but lack selectivity for Abeta42.
Positive_regulation (selectivity) of Localization (secretion) of Abeta associated with alzheimer's dementia and abeta
17) Confidence 0.06 Published 2006 Journal J. Neurochem. Section Title Doc Link 16300630 Disease Relevance 0.26 Pain Relevance 0.68

General Comments

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