INT116275

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Context Info
Confidence 0.62
First Reported 2004
Last Reported 2009
Negated 1
Speculated 1
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.95
Pain Relevance 1.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Gpr156) signal transducer activity (Gpr156)
Anatomy Link Frequency
neurons 2
spinal cord 2
ventral 2
Gpr156 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Ventral tegmentum 69 100.00 Very High Very High Very High
Desipramine 6 99.98 Very High Very High Very High
Dorsal horn 3 99.16 Very High Very High Very High
Nicotine 43 98.92 Very High Very High Very High
Spinal cord 4 98.24 Very High Very High Very High
Pain 1 97.92 Very High Very High Very High
gABA 10 96.06 Very High Very High Very High
cocaine 1 93.56 High High
Neuropathic pain 1 86.16 High High
Nucleus accumbens 9 85.96 High High
Disease Link Frequency Relevance Heat
Convulsion 63 99.98 Very High Very High Very High
Pain 2 97.92 Very High Very High Very High
Neuropathic Pain 1 86.16 High High
Injury 1 85.20 High High
Apoptosis 25 61.00 Quite High
Epilepsy 19 50.00 Quite Low
Death 12 48.92 Quite Low
Fetal Alcohol Syndrome 4 5.00 Very Low Very Low Very Low
Decapitation 3 5.00 Very Low Very Low Very Low
Cognitive Disorder 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because previous reports suggest these agents may influence gamma-aminobutyric acid (GABA) neurotransmission, and GABAB receptors are known to participate in the transmission of pain impulses, the present experiments were undertaken to examine whether the administration of desipramine alters GABAB receptor subunit expression and function in the dorsal horn of the rat spinal cord.
Spec (whether) Regulation (alters) of Gene_expression (expression) of GABAB in spinal cord associated with pain, desipramine, gaba, dorsal horn and spinal cord
1) Confidence 0.62 Published 2004 Journal Biochem. Pharmacol. Section Abstract Doc Link 14757174 Disease Relevance 0.24 Pain Relevance 0.85
However, we have previously demonstrated that GABAB receptor expression and coupling to G-proteins in the ventral tegmental area of the rat are not altered after chronic exposure to nicotine [52], suggesting that desensitisation might occur at other levels, perhaps on downstream effector mechanisms.
Neg (not) Regulation (altered) of Gene_expression (expression) of GABAB in ventral associated with ventral tegmentum and nicotine
2) Confidence 0.38 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC526276 Disease Relevance 0 Pain Relevance 0.73
PTZ-induced seizure modulate GABAB1R expression in prenatal rat hippocampal neurons
Regulation (modulate) of Gene_expression (expression) of GABAB1R in neurons associated with convulsion
3) Confidence 0.15 Published 2009 Journal Mol Brain Section Body Doc Link PMC2706809 Disease Relevance 0.71 Pain Relevance 0.04

General Comments

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