INT116276

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Context Info
Confidence 0.47
First Reported 2004
Last Reported 2006
Negated 1
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.51
Pain Relevance 1.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Gpr156) signal transducer activity (Gpr156)
Gpr156 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 1 100.00 Very High Very High Very High
Desipramine 6 98.04 Very High Very High Very High
nMDA receptor 1 97.48 Very High Very High Very High
opioid receptor 1 96.20 Very High Very High Very High
Opioid 3 95.32 Very High Very High Very High
Antinociceptive 2 95.12 Very High Very High Very High
dorsal root ganglion 6 94.00 High High
Pain threshold 1 93.44 High High
Spinal cord 6 89.92 High High
Dorsal horn 3 87.12 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 6 94.00 High High
Pain 2 93.44 High High
Neuropathic Pain 1 57.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, it was found that 7 days of treatment with desipramine enhances GABAB receptor function, as measured by baclofen-stimulated [35S]GTPgammaS binding, and increases mRNA expression for the GABAB(1a) and GABAB(2), but not GABAB(1b), subunits.
Positive_regulation (increases) of Transcription (expression) of GABAB associated with desipramine
1) Confidence 0.47 Published 2004 Journal Biochem. Pharmacol. Section Abstract Doc Link 14757174 Disease Relevance 0.22 Pain Relevance 1.02
GeneChip analysis revealed that neither estrogen nor contraction alone changed the mRNA expression of substance P, the neurokinin-1 receptor, CGRP, NGF, the P2X3 receptor, GABAA and GABAB, the 5-HT3A and 5-HT3B receptor, N-methyl-D-aspartate and non-N-methyl-D-aspartate receptors, opioid receptors, and opioid-like receptor.
Neg (neither) Positive_regulation (changed) of Transcription (expression) of GABAB associated with nmda receptor, opioid receptor, opioid and substance p
2) Confidence 0.02 Published 2006 Journal J. Appl. Physiol. Section Abstract Doc Link 16306253 Disease Relevance 0.29 Pain Relevance 0.83

General Comments

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