INT116277

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Context Info
Confidence 0.53
First Reported 2004
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 2.53
Pain Relevance 5.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Gpr156) signal transducer activity (Gpr156)
Anatomy Link Frequency
neuronal 1
spinal cord dorsal horn 1
Gpr156 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 35 100.00 Very High Very High Very High
cytokine 4 100.00 Very High Very High Very High
substance P 1 100.00 Very High Very High Very High
adenocard 5 99.80 Very High Very High Very High
gABA 17 99.78 Very High Very High Very High
withdrawal 6 98.50 Very High Very High Very High
Spinal cord 21 98.12 Very High Very High Very High
spinal dorsal horn 38 97.92 Very High Very High Very High
Desipramine 24 97.74 Very High Very High Very High
Dorsal horn 12 97.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 35 100.00 Very High Very High Very High
Convulsion 63 97.54 Very High Very High Very High
Nociception 20 97.24 Very High Very High Very High
Ganglion Cysts 6 93.32 High High
Pain 18 92.84 High High
Injury 6 74.08 Quite High
Neuropathic Pain 4 73.64 Quite High
Hypoalagesia 3 51.20 Quite High
Apoptosis 25 50.00 Quite Low
Epilepsy 19 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, it was found that 7 days of treatment with desipramine enhances GABAB receptor function, as measured by baclofen-stimulated [35S]GTPgammaS binding, and increases mRNA expression for the GABAB(1a) and GABAB(2), but not GABAB(1b), subunits.
Transcription (expression) of GABAB associated with desipramine
1) Confidence 0.53 Published 2004 Journal Biochem. Pharmacol. Section Abstract Doc Link 14757174 Disease Relevance 0.22 Pain Relevance 1.01
For the study, rats were injected (i.p.) once daily with desipramine (15 mg/kg) for 7 consecutive days, during which their thermal withdrawal threshold was monitored, and after which GABAB receptor function, and the levels of GABAB receptor subunit mRNA, were quantified in the spinal cord dorsal horn.
Transcription (levels) of GABAB in spinal cord dorsal horn associated with desipramine, dorsal horn, withdrawal and spinal cord
2) Confidence 0.53 Published 2004 Journal Biochem. Pharmacol. Section Abstract Doc Link 14757174 Disease Relevance 0.24 Pain Relevance 0.96
Moreover, it was found that 7 days of treatment with desipramine enhances GABAB receptor function, as measured by baclofen-stimulated [35S]GTPgammaS binding, and increases mRNA expression for the GABAB(1a) and GABAB(2), but not GABAB(1b), subunits.
Transcription (expression) of GABAB associated with desipramine
3) Confidence 0.53 Published 2004 Journal Biochem. Pharmacol. Section Abstract Doc Link 14757174 Disease Relevance 0.22 Pain Relevance 1.01
Moreover, it was found that 7 days of treatment with desipramine enhances GABAB receptor function, as measured by baclofen-stimulated [35S]GTPgammaS binding, and increases mRNA expression for the GABAB(1a) and GABAB(2), but not GABAB(1b), subunits.
Transcription (expression) of GABAB associated with desipramine
4) Confidence 0.46 Published 2004 Journal Biochem. Pharmacol. Section Abstract Doc Link 14757174 Disease Relevance 0.22 Pain Relevance 1.02
To further explore the in vivo changes of GABAB1R and its relation with PTZ-induced seizure effect on hippocampal neuronal cells, primary cultured cells from control, baclofen, phaclofen treatment were studied and GABAB1R mRNA level was examined by using RT-PCR.
Spec (examined) Transcription (level) of GABAB1R in neuronal associated with convulsion
5) Confidence 0.24 Published 2009 Journal Mol Brain Section Body Doc Link PMC2706809 Disease Relevance 0.69 Pain Relevance 0.06
GeneChip analysis revealed that neither estrogen nor contraction alone changed the mRNA expression of substance P, the neurokinin-1 receptor, CGRP, NGF, the P2X3 receptor, GABAA and GABAB, the 5-HT3A and 5-HT3B receptor, N-methyl-D-aspartate and non-N-methyl-D-aspartate receptors, opioid receptors, and opioid-like receptor.
Transcription (expression) of GABAB associated with nmda receptor, opioid receptor, opioid and substance p
6) Confidence 0.03 Published 2006 Journal J. Appl. Physiol. Section Abstract Doc Link 16306253 Disease Relevance 0.29 Pain Relevance 0.83
These include genes encoding GAD65 GABA synthesis enzyme, anti-inflammatory cytokine, IL-10, and GABAB1d, A1 adenosine, ?
Transcription (enzyme) of GABAB1d associated with adenocard, gaba, inflammation and cytokine
7) Confidence 0.01 Published 2005 Journal Mol Pain Section Body Doc Link PMC1242251 Disease Relevance 0.66 Pain Relevance 0.72

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