INT11628

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Context Info
Confidence 0.61
First Reported 1982
Last Reported 2011
Negated 6
Speculated 8
Reported most in Abstract
Documents 44
Total Number 53
Disease Relevance 10.46
Pain Relevance 18.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pomc) generation of precursor metabolites and energy (Pomc) extracellular space (Pomc)
extracellular region (Pomc) cell-cell signaling (Pomc) cytoplasm (Pomc)
Anatomy Link Frequency
pituitary 20
PVN 6
anterior pituitary 4
pars distalis 3
plasma 2
Pomc (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 196 100.00 Very High Very High Very High
Morphine 50 100.00 Very High Very High Very High
narcan 49 100.00 Very High Very High Very High
Enkephalin 20 100.00 Very High Very High Very High
Catecholamine 19 100.00 Very High Very High Very High
Clonidine 14 100.00 Very High Very High Very High
noradrenaline 11 100.00 Very High Very High Very High
Dynorphin 9 100.00 Very High Very High Very High
qutenza 8 100.00 Very High Very High Very High
opiate 7 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 516 100.00 Very High Very High Very High
Pituitary Cancer 58 99.68 Very High Very High Very High
Intractable Pain 2 99.30 Very High Very High Very High
Myocardial Infarction 6 99.28 Very High Very High Very High
Pain 6 99.24 Very High Very High Very High
Cv Unclassified Under Development 4 98.98 Very High Very High Very High
Injury 13 98.40 Very High Very High Very High
Disease 53 98.24 Very High Very High Very High
Acth-secreting Pituitary Adenoma 21 98.20 Very High Very High Very High
Syndrome 13 97.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The influence of capsaicin sensitive neurons on stress-induced release of ACTH.
Regulation (influence) of Localization (release) of ACTH in neurons associated with stress and qutenza
1) Confidence 0.61 Published 1986 Journal Brain Res. Bull. Section Title Doc Link 3013379 Disease Relevance 0.28 Pain Relevance 0.71
This study was designed to examine in rats the effects of systemic administration of a potent met-enkephalin analog, D-Ala2-met-enkephalinamide (DALA), on plasma ACTH and corticosterone secretion under basal conditions.
Spec (examine) Regulation (effects) of Localization (secretion) of ACTH in plasma associated with enkephalin
2) Confidence 0.60 Published 1982 Journal Endocrinology Section Abstract Doc Link 6290184 Disease Relevance 0 Pain Relevance 0.23
The role of alpha-2-adrenoceptors in the control of ACTH secretion; interaction with the opioid system.
Regulation (control) of Localization (secretion) of ACTH associated with narcan and opioid
3) Confidence 0.58 Published 1990 Journal Neuroendocrinology Section Title Doc Link 1968233 Disease Relevance 0 Pain Relevance 0.62
This study examined the effects of an alpha-2-adrenoceptor antagonist on the secretion of ACTH basally and in response to the opioid antagonist naloxone, which is known to stimulate ACTH secretion by an adrenergic mechanism.
Spec (examined) Regulation (effects) of Localization (secretion) of ACTH associated with antagonist, narcan and opioid
4) Confidence 0.58 Published 1990 Journal Neuroendocrinology Section Abstract Doc Link 1968233 Disease Relevance 0 Pain Relevance 0.50
The objective of the present studies was to investigate the effects of various concentrations of ethanol on the release of beta-endorphin (beta-EP) by the hypothalami of mice showing either high (C57BL/6) or low (DBA/2) voluntary ethanol consumption.
Spec (investigate) Regulation (effects) of Localization (release) of beta-endorphin
5) Confidence 0.58 Published 1992 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1578384 Disease Relevance 0.07 Pain Relevance 0.17
To determine the locus of opiate modulation of ACTH secretion, 11 normal subjects were given ovine corticotropin-releasing hormone (CRH) 30 min after receiving either placebo or morphine sulfate.
Regulation (modulation) of Localization (secretion) of ACTH associated with opiate and morphine
6) Confidence 0.57 Published 1985 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2984235 Disease Relevance 0 Pain Relevance 0.50
A perifusion system was developed to investigate the control of alpha-melanocyte-stimulating hormone (alpha-MSH) release from rat brain.
Spec (investigate) Regulation (control) of Localization (release) of alpha-MSH in brain
7) Confidence 0.52 Published 1987 Journal Brain Res. Section Abstract Doc Link 3607476 Disease Relevance 0 Pain Relevance 0.14
Effect of S(-)- and R(+)-salsolinol on the POMC gene expression and ACTH release of an anterior pituitary cell line.
Regulation (Effect) of Localization (release) of ACTH in anterior pituitary
8) Confidence 0.45 Published 1995 Journal Alcohol Section Title Doc Link 8519440 Disease Relevance 0.17 Pain Relevance 0.33
Factors regulating foetal pituitary adrenocorticotrophin (ACTH) secretion have been delineated, and these include corticotrophin releasing hormone (CRH), arginine vasopressin, prostaglandin (PG) E2 and endogenous opioids.
Regulation (regulating) of Localization (secretion) of ACTH in pituitary associated with endogenous opioid
9) Confidence 0.45 Published 1993 Journal Equine Vet J Suppl Section Abstract Doc Link 9079135 Disease Relevance 0 Pain Relevance 0.09
These data suggest that endogenous opioid peptides regulate pituitary-adrenocortical secretion under basal conditions by modifying both ACTH secretion and the glucocorticoid response to ACTH.
Regulation (regulate) of Localization (secretion) of ACTH in pituitary associated with endogenous opioid
10) Confidence 0.44 Published 1982 Journal Endocrinology Section Abstract Doc Link 6290184 Disease Relevance 0 Pain Relevance 0.33
Secretion of pituitary immunoreactive beta-endorphin is hypothesized to modulate the perception of pain.
Regulation (modulate) of Localization (Secretion) of beta-endorphin in pituitary associated with pain
11) Confidence 0.43 Published 1987 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 2961501 Disease Relevance 0.36 Pain Relevance 0.51
Naloxone had no effects on ACTH hypersecretion or normal ACTH levels.
Neg (no) Regulation (effects) of Localization (hypersecretion) of ACTH associated with narcan
12) Confidence 0.43 Published 1988 Journal Horm. Metab. Res. Section Abstract Doc Link 2840381 Disease Relevance 0.59 Pain Relevance 0.35
The effects of acute and chronic treatment with morphine and stadol on the functional activity of the hypothalamo-pituitary-adrenocortical (HPA) system in the rat were studied by investigating their effects on the secretion of adrenocorticotrophin (ACTH) by the pituitary gland and corticotrophin-releasing hormone (CRH) by the hypothalamus.
Spec (investigating) Regulation (effects) of Localization (secretion) of ACTH in pituitary associated with morphine
13) Confidence 0.43 Published 1996 Journal Life Sci. Section Abstract Doc Link 8950285 Disease Relevance 0.15 Pain Relevance 0.39
On day 4, the amount of ACTH secretion was dependent on the Dox dose.
Regulation (dependent) of Localization (secretion) of ACTH
14) Confidence 0.41 Published 1999 Journal Cell Transplant Section Abstract Doc Link 10478725 Disease Relevance 0.13 Pain Relevance 0.14
Further studies are needed to analyze the short-term and long-term effects of monoamines on the regulation of the PVN and the modification of CRF and ACTH release under stressful conditions.
Regulation (regulation) of Localization (release) of ACTH associated with monoamine
15) Confidence 0.39 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2845127 Disease Relevance 0.62 Pain Relevance 0.19
It was concluded that the increases in serum glucose and corticosterone after clonidine administration were not mediated by central effects but that alpha 2-adrenoceptor agonism by clonidine was responsible for inhibition of hypothalamic noradrenaline neuronal activity and pituitary ACTH release.
Regulation (responsible) of Localization (release) of ACTH in pituitary associated with noradrenaline and clonidine
16) Confidence 0.39 Published 1985 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2990960 Disease Relevance 0 Pain Relevance 0.74
Based on the type of exercise, different mechanisms may be involved in the regulation of beta-endorphin release during exercise.
Regulation (regulation) of Localization (release) of beta-endorphin
17) Confidence 0.36 Published 1997 Journal Sports Med Section Abstract Doc Link 9257407 Disease Relevance 0 Pain Relevance 0.17
Naloxone had no effects on ACTH hypersecretion or normal ACTH levels.
Neg (no) Regulation (effects) of Localization (hypersecretion) of ACTH associated with narcan
18) Confidence 0.32 Published 1988 Journal Horm. Metab. Res. Section Abstract Doc Link 2840381 Disease Relevance 0.59 Pain Relevance 0.36
Attempted gene therapy for intractable pain: dexamethasone-mediated exogenous control of beta-endorphin secretion in genetically modified cells and intrathecal transplantation.
Regulation (control) of Localization (secretion) of beta-endorphin associated with intractable pain, narcan, dexamethasone and intrathecal
19) Confidence 0.31 Published 2000 Journal Exp. Neurol. Section Title Doc Link 11031086 Disease Relevance 0.27 Pain Relevance 0.68
Regulation of pituitary ACTH secretion during chronic stress.
Regulation (Regulation) of Localization (secretion) of ACTH in pituitary associated with stress
20) Confidence 0.28 Published 1994 Journal Front Neuroendocrinol Section Title Doc Link 7895891 Disease Relevance 0.66 Pain Relevance 0.08

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