INT116280

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Context Info
Confidence 0.67
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 6.52
Pain Relevance 2.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp13) extracellular space (Mmp13) extracellular region (Mmp13)
Golgi apparatus (Mmp13) proteinaceous extracellular matrix (Mmp13) lysosome (Mmp13)
Anatomy Link Frequency
macrophages 1
chondrocytes 1
joints 1
fibroblasts 1
Mmp13 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 135 98.72 Very High Very High Very High
Arthritis 140 97.44 Very High Very High Very High
metalloproteinase 113 92.08 High High
Osteoarthritis 19 87.16 High High
Inflammation 132 86.64 High High
anesthesia 2 78.96 Quite High
cytokine 12 70.84 Quite High
Inflammatory response 5 68.96 Quite High
Pain 10 63.20 Quite High
fibrosis 41 60.84 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 12 99.66 Very High Very High Very High
Fibrosis 54 99.64 Very High Very High Very High
Arthritis 155 98.84 Very High Very High Very High
Rheumatoid Arthritis 135 98.72 Very High Very High Very High
Coronary Heart Disease 32 96.52 Very High Very High Very High
Metastasis 6 94.64 High High
Breast Cancer 4 93.28 High High
Frailty 9 87.16 High High
INFLAMMATION 136 86.64 High High
Peptic Ulcer 2 83.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the contribution of particular collagenases towards the destruction of arthritic joints remains to be clearly demonstrated.
Transcription (contribution) of collagenase in joints associated with arthritis
1) Confidence 0.67 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC154424 Disease Relevance 0.47 Pain Relevance 0.12
The triple-helical appearance of the immunogold label, and the sensitivity of the Mps1 and Polo localization to collagenase, are consistent with the underlying protein scaffold being a collagen-like protein.
Transcription (sensitivity) of collagenase
2) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2761730 Disease Relevance 0.12 Pain Relevance 0
Physiologically MMP-13 activity is controlled by naturally occurring inhibitors such as ?
Transcription (activity) of MMP-13
3) Confidence 0.57 Published 2010 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2925150 Disease Relevance 0.35 Pain Relevance 0.28
In transgenic mice, excessive MMP-13 activity can result in articular cartilage degradation.25 In RA synovial tissues, MMP-13 is detected in fibroblasts, chondrocytes, macrophages and vascular endothelial cells.26–28 Most importantly, MMP-13 is detected at sites of joint destruction.29 30
Transcription (activity) of MMP-13 in chondrocytes associated with targeted disruption and rheumatoid arthritis
4) Confidence 0.57 Published 2010 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2925150 Disease Relevance 0.81 Pain Relevance 0.30
Irsogladine failed to inhibit proliferation, tubular formation, and the uPA/MMP-1 mRNA expression of HUVEC cells.
Transcription (expression) of MMP-1
5) Confidence 0.52 Published 2004 Journal Breast Cancer Res. Treat. Section Abstract Doc Link 14758089 Disease Relevance 1.01 Pain Relevance 0.08
Our data show a strong upregulation of the mRNA expression of collagenase (MMP1) and both gelatinases (MMP2 and MMP9) compared with controls.
Transcription (expression) of MMP1
6) Confidence 0.43 Published 2010 Journal J Cardiothorac Surg Section Body Doc Link PMC2933604 Disease Relevance 0.38 Pain Relevance 0.19
Our data show a strong upregulation of the mRNA expression of collagenase (MMP1) and both gelatinases (MMP2 and MMP9) compared with controls.
Transcription (expression) of collagenase
7) Confidence 0.43 Published 2010 Journal J Cardiothorac Surg Section Body Doc Link PMC2933604 Disease Relevance 0.37 Pain Relevance 0.19
In fibrotic animals, hepatic expression of MMP-2, MMP-3, MMP-8, MMP-9 and MMP-13 mRNA were all significantly upregulated, compared to non-fibrotic controls (Figure 6).
Transcription (expression) of MMP-13 associated with fibrosis
8) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892485 Disease Relevance 0.33 Pain Relevance 0.06
In transgenic mice, excessive MMP-13 activity can result in articular cartilage degradation.25 In RA synovial tissues, MMP-13 is detected in fibroblasts, chondrocytes, macrophages and vascular endothelial cells.26–28 Most importantly, MMP-13 is detected at sites of joint destruction.29 30
Transcription (activity) of MMP-13 in fibroblasts associated with targeted disruption and rheumatoid arthritis
9) Confidence 0.19 Published 2010 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2925150 Disease Relevance 0.81 Pain Relevance 0.30
In transgenic mice, excessive MMP-13 activity can result in articular cartilage degradation.25 In RA synovial tissues, MMP-13 is detected in fibroblasts, chondrocytes, macrophages and vascular endothelial cells.26–28 Most importantly, MMP-13 is detected at sites of joint destruction.29 30
Transcription (activity) of MMP-13 in macrophages associated with targeted disruption and rheumatoid arthritis
10) Confidence 0.19 Published 2010 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2925150 Disease Relevance 0.81 Pain Relevance 0.30
also stimulated collagenase gene transcription.
Transcription (transcription) of collagenase
11) Confidence 0.07 Published 2010 Journal Virol J Section Body Doc Link PMC2976746 Disease Relevance 1.07 Pain Relevance 0.23

General Comments

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