INT116281

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Context Info
Confidence 0.41
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 9.96
Pain Relevance 3.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp13) extracellular space (Mmp13) extracellular region (Mmp13)
Golgi apparatus (Mmp13) proteinaceous extracellular matrix (Mmp13) lysosome (Mmp13)
Anatomy Link Frequency
chondrocytes 8
endochondral bone 2
extracellular matrix 2
Mmp13 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 295 100.00 Very High Very High Very High
rheumatoid arthritis 289 100.00 Very High Very High Very High
cytokine 123 99.88 Very High Very High Very High
ischemia 22 98.96 Very High Very High Very High
Leflunomide 3 98.32 Very High Very High Very High
antagonist 15 98.16 Very High Very High Very High
dexamethasone 22 97.68 Very High Very High Very High
Arthritis 166 96.84 Very High Very High Very High
Inflammation 150 94.64 High High
Osteoarthritis 79 83.88 Quite High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 333 100.00 Very High Very High Very High
Cv General 4 Under Development 5 99.32 Very High Very High Very High
Severe Combined Immunodeficiency 32 99.24 Very High Very High Very High
Osteoarthritis 91 99.04 Very High Very High Very High
Starvation 4 99.02 Very High Very High Very High
Hypertrophy 23 98.08 Very High Very High Very High
Arthritis 179 96.84 Very High Very High Very High
Metastasis 70 96.80 Very High Very High Very High
Disease 104 95.56 Very High Very High Very High
Breast Cancer 23 95.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Irsogladine failed to inhibit proliferation, tubular formation, and the uPA/MMP-1 mRNA expression of HUVEC cells.
Negative_regulation (inhibit) of Gene_expression (expression) of MMP-1
1) Confidence 0.41 Published 2004 Journal Breast Cancer Res. Treat. Section Abstract Doc Link 14758089 Disease Relevance 1.01 Pain Relevance 0.08
2 in cultured human osteoarthritic cartilage has been shown to be associated with decreased expression of collagenases, cytokines, genes associated with chondrocyte hypertrophy, and upregulation of prostaglandin (PG)E2 production.
Negative_regulation (decreased) of Gene_expression (expression) of collagenase in chondrocyte associated with hypertrophy, osteoarthritis and cytokine
2) Confidence 0.41 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC2206385 Disease Relevance 0.72 Pain Relevance 0.05
Previous studies, however, have shown that multiple tetracyclines can inhibit collagenase MMPs via down-regulation of gene expression in a cellular model of rheumatoid arthritis using cultured chondrocytes [33] and that pre-treatment with minocycline down-regulates pro-MMP expression after permanent cerebral ischemia [17].
Negative_regulation (inhibit) of Gene_expression (expression) of collagenase in chondrocytes associated with cv general 4 under development, ischemia and rheumatoid arthritis
3) Confidence 0.41 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1543649 Disease Relevance 0.70 Pain Relevance 0.21
All patients with RA fulfilled the American College of Rheumatology criteria for the classification of RA.8 The MMP-13 selective inhibitor used in this study is described as Compound 2 in a recent publication.7

Immunohistochemistry

Negative_regulation (inhibitor) of Gene_expression (selective) of MMP-13 associated with rheumatoid arthritis
4) Confidence 0.35 Published 2010 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2925150 Disease Relevance 1.07 Pain Relevance 0.41
Bisphosphonates also inhibit collagenase-3 expression, an enzyme essential for endochondral bone development [27].
Negative_regulation (inhibit) of Gene_expression (expression) of collagenase-3 in endochondral bone
5) Confidence 0.21 Published 2008 Journal The Open Orthopaedics Journal Section Body Doc Link PMC2703200 Disease Relevance 0.40 Pain Relevance 0
An increased propensity for extracellular matrix (ECM) remodeling is suggested by elevated expression of matrix metalloproteinases (Mmp3, Mmp9 and Mmp13), urokinase-type plasminogen activator (Plau) and secreted protease inhibitors (Serpina3g, Serpin2 and Lcn2).
Negative_regulation (inhibitors) of Gene_expression (expression) of Mmp13 in extracellular matrix associated with metalloproteinase
6) Confidence 0.18 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2529338 Disease Relevance 0.43 Pain Relevance 0.12
MMP-13 expression in wildtype cells was efficiently reduced by either treatment, while the inhibitory effect of both substances was fully abolished in MEFs from GRN?
Negative_regulation (reduced) of Gene_expression (expression) of MMP-13
7) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2781169 Disease Relevance 0.46 Pain Relevance 0.24
RAW transfectants over-expressing IDO showed reduced expression of collagenase I (MMP-1), and also bound less well to collagen-coated plates than controls.
Negative_regulation (reduced) of Gene_expression (expression) of collagenase I
8) Confidence 0.14 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0.15 Pain Relevance 0.04
This reduction in MMP-13 production was not statistically significant.
Negative_regulation (reduction) of Gene_expression (production) of MMP-13 associated with metalloproteinase
9) Confidence 0.13 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888198 Disease Relevance 0.71 Pain Relevance 1.07
For instance, leflunomide was found to act on RASFs by downregulating MAPK signalling pathways, resulting in inhibition of the production of MMP-1, MMP-3 and MMP-13, and in increased synthesis of IL-1 receptor antagonist [51,52].


Negative_regulation (inhibition) of Gene_expression (production) of MMP-13 associated with antagonist and leflunomide
10) Confidence 0.09 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246247 Disease Relevance 0.26 Pain Relevance 0.19
Similarly, Manacu et al. [72] found that, in primary cultures of human osteoarthritic chondrocytes, the presence of ET-1 in the medium triggered increased production of MMP-1 and MMP-13.
Negative_regulation (triggered) of Gene_expression (production) of MMP-13 in chondrocytes associated with osteoarthritis
11) Confidence 0.06 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2913859 Disease Relevance 0.67 Pain Relevance 0.18
They can inhibit the activity and production of MMPs (MMP-1, MMP-3 and MMP-13, and MMP-2 and MMP-9).
Negative_regulation (inhibit) of Gene_expression (production) of MMP-13 associated with metalloproteinase
12) Confidence 0.05 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212555 Disease Relevance 1.15 Pain Relevance 0.27
SB203580, a p38 mitogen-activated protein kinase inhibitor, blocks both MMP-13 gene expression in cultured chondrocytes and IL-1 mediated collagen degradation in cartilage explants.
Negative_regulation (blocks) of Gene_expression (expression) of MMP-13 in chondrocytes
13) Confidence 0.05 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212555 Disease Relevance 0.77 Pain Relevance 0.15
The consequent tryptophan catabolism and ensuing tryptophan starvation in these cultures were associated with profound suppression of collagenase and stromelysin gene expression induced by IL-1?.
Negative_regulation (suppression) of Gene_expression (expression) of collagenase associated with starvation
14) Confidence 0.03 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206348 Disease Relevance 0.78 Pain Relevance 0.19
Despite an effect on the expression of c-Jun, as well as on the expression of MMP-1 and MMP-13, however, invasiveness of RA-SFs was not inhibited completely in the SCID mouse model.
Negative_regulation (inhibited) of Gene_expression (expression) of MMP-13 associated with severe combined immunodeficiency and rheumatoid arthritis
15) Confidence 0.03 Published 1999 Journal Arthritis Res Section Body Doc Link PMC128862 Disease Relevance 0.67 Pain Relevance 0.22

General Comments

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